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Eltanexor and Venetoclax in Relapsed or Refractory Myelodysplastic Syndrome and Acute Myeloid Leukemia

for
Relapsed Myelodysplastic Syndrome,
Location: Nashville TN, Memphis TN
Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All

Age: 18+

Code: NCT06399640

Phase1, Recruiting

Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

for
Refractory Acute Myeloid Leukemia,
Location: New York NY, Philadelphia PA, Atlanta GA, Cincinnati OH,
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 1 - 30

Code: NCT06177067

Phase1, Recruiting

Mismatched Donor Cells to Treat Acute Myeloid Leukemia

for
Acute Myeloid Leukemia
Location: Montreal
Sponsor: Maisonneuve-Rosemont Hospital

Sex: All

Age: 18+

Code: NCT01793025

Phase1, Recruiting

A Study of BGB-11417 in Participants With Myeloid Malignancies

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes,
Location: Pittsburgh PA, Tampa FL, Milwaukee WI, Houston TX
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT04771130

Phase1, Phase2, Recruiting

ASTX727, Venetoclax, and Gilteritinib for the Treatment of Newly Diagnosed, Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

for
Acute Myeloid Leukemia, Myelodysplastic Syndrome,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05010122

Phase1, Phase2, Recruiting

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Iadademstat in Combination With Azacitidine and Venetoclax in Treating Newly Diagnosed Acute Myeloid Leukemia

for
Acute Myeloid Leukemia,
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT06357182

Phase1, Recruiting

Tagraxofusp and Azacitidine for Maintenance Treatment in Patients With CD123 Positive AML and MDS Following Donor Hematopoietic Cell Transplant

for
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18 - 70+

Code: NCT06498973

Phase1, Recruiting

Discontinuation of Hypomethylating Agent and Venetoclax in Patients With AML MRD

for
Acute Myeloid Leukemia
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT06511882

Phase2, Recruiting

MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG Dosing

for
Leukemia, Acute Myeloid Leukemia in Remission, Myelodysplasia,
Location: Milwaukee WI
Sponsor: Medical College of Wisconsin

Sex: All

Age: 0 - 25

Code: NCT05794880

Recruiting

A Phase I-II Study Investigating the All-Oral Combination of the Menin Inhibitor SNDX-5613 With Decitabine/Cedazuridine (ASTX727) and Venetoclax in Acute Myeloid Leukemia (SAVE)

for
Acute Myeloid Leukemia
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 12+

Code: NCT05360160

Phase1, Phase2, Recruiting

Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies

for
Acute Myeloid Leukemia,
Location: Boston MA, Cleveland OH, Houston TX, Portland OR
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03471260

Phase1, Phase2, Recruiting

Cardioprotection in AML

for
AML, Acute Myeloid Leukemia
Location: Charlottesville VA
Sponsor: University of Virginia

Sex: All

Age: 18+

Code: NCT04977180

Phase2, Recruiting

SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

for
Acute Myeloid Leukemia With FLT3/ITD Mutation,
Location: Philadelphia PA, Chapel Hill NC, Columbus OH,
Sponsor: Uma Borate

Sex: All

Age: 18+

Code: NCT06222580

Phase1, Recruiting

CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia

for
Recurrent Acute Myeloid Leukemia,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT04375631

Phase1, Recruiting

Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy

for
Acute Myeloid Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 1+

Code: NCT03630991

Phase1, Recruiting

Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)

for
Acute Myeloid Leukemia, Acute Lymphoid Leukemia,
Location: Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 0 - 50

Code: NCT05322850

Phase1, Phase2, Recruiting

MiRisten for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

for
Recurrent Acute Myeloid Leukemia,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07025564

Phase1, Recruiting

Quizartinib, Decitabine, and Venetoclax in Treating Participants With Untreated or Relapsed Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

for
Acute Myeloid Leukemia, Myelodysplastic Syndrome,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03661307

Phase1, Phase2, Recruiting

Comparing Different Treatment Lengths for Venetoclax in Older People With Newly Diagnosed Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

for
Acute Myeloid Leukemia
Location: Buffalo NY, Pontiac MI, Livonia MI, Canton MI,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 60+

Code: NCT07437950

Phase2, Recruiting

Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML

for
Acute Myeloid Leukemia, Adult
Location: Baltimore MD, Chapel Hill NC, Pittsburgh PA,
Sponsor: Stichting Hemato-Oncologie voor Volwassenen Nederland

Sex: All

Age: 18+

Code: NCT06652438

Phase3, Recruiting