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Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors

for
Cancer, Metastatic Cancer, Locally Advanced,
Location: Cincinnati OH
Sponsor: University of Cincinnati

Sex: All

Age: 18+

Code: NCT06416007

Phase2, Recruiting

Tumor Immunotherapy and Microbiome Analysis

for
Advanced Solid Tumor
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18+

Code: NCT04579978

Recruiting

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

for
Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC),
Location: Boston MA, New York NY, Baltimore MD, Fairfax VA,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT05379985

Phase1, Phase2, Recruiting

A Study of RX108 in Patients With Locally Advanced or Metastatic Solid Tumors

for
Locally Advanced Solid Tumors, Metastatic Solid Tumors
Location: Houston TX, Los Angeles CA
Sponsor: NeuPharma, Inc.

Sex: All

Age: 18+

Code: NCT03646071

Phase1, Recruiting

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumor, Melanoma, Head and Neck Cancer,
Location: New Haven CT, New York NY, Baltimore MD, Buffalo NY,
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT06172478

Phase2, Recruiting

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A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Boston MA, Toronto, Ann Arbor MI, Houston TX, Dallas TX,
Sponsor: LigaChem Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT05941507

Phase1, Phase2, Recruiting

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

for
Advanced Solid Tumor, High Grade Serous Adenocarcinoma of Ovary,
Location: Providence RI, New Haven CT, New York NY, Baltimore MD,
Sponsor: Volastra Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05902988

Phase1, Phase2, Recruiting

Study of Lunresertib Alone or in Combination With RP-3500 or Debio 0123 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Boston MA, Providence RI, New Haven CT,
Sponsor: Debiopharm International SA

Sex: All

Age: 12+

Code: NCT04855656

Phase1, Recruiting

A Phase 1/2 Study of KSQ-004EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate Genes Encoding SOCS1 and Regnase-1, in Patients With Select Advanced Solid Tumors

for
Select Advanced Solid Tumors
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06598371

Phase1, Phase2, Recruiting

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for
Advanced Solid Tumors With KRAS G12C Mutations,
Location: Boston MA, Philadelphia PA, Fairfax VA, Detroit MI,
Sponsor: Frontier Medicines Corporation

Sex: All

Age: 18+

Code: NCT06244771

Phase1, Phase2, Recruiting

Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: North Haven CT, Ottawa, Toronto, Orlando FL,
Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All

Age: 18+

Code: NCT06384352

Phase1, Recruiting

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

for
Low-grade Glioma, Advanced Solid Tumor
Location: Boston MA, Quebec, New York NY, Montreal,
Sponsor: Day One Biopharmaceuticals, Inc.

Sex: All

Age: 0 - 25

Code: NCT04775485

Phase2, Recruiting

Phase 1 Study of Intratumoral Administration of VAX014 With Expansion in Combination With a Checkpoint Inhibitor in Subjects With Advanced Solid Tumors

for
Advanced Solid Tumor,
Location: Boston MA, Lebanon NH, Morristown NJ,
Sponsor: Vaxiion Therapeutics

Sex: All

Age: 18+

Code: NCT05901285

Phase1, Recruiting

A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors

for
Metastatic Solid Tumor, Advanced Solid Tumor,
Location: Boston MA, New York NY, Fairfax VA, Miami FL,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06561685

Phase1, Recruiting

SLV-154 Treatment of Advanced Cancers

for
Advanced Cancer, Advanced Solid Tumor, Metastatic Cancer
Location: New York NY, East Brunswick NJ, Cleveland OH,
Sponsor: Solve Therapeutics

Sex: All

Age: 12+

Code: NCT06771219

Phase1, Recruiting

ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR)

for
Locally Advanced Solid Tumor, Metastatic Solid Tumor
Location: Nashville TN, Dallas TX, Denver CO, San Diego CA
Sponsor: Acepodia Biotech, Inc.

Sex: All

Age: 18+

Code: NCT06415487

Phase1, Recruiting

Safety, Pharmacokinetics, and Clinical Activity of LP-284 in Adult Patients With Relapsed or Refractory Lymphomas and Solid Tumors

for
Relapsed or Refractory Lymphomas, Advanced Solid Tumor
Location: West Valley City UT
Sponsor: Lantern Pharma Inc.

Sex: All

Age: 18+

Code: NCT06132503

Phase1, Recruiting

A Study of PARP1 Selective Inhibitor, EIK1004 (IMP1707) in Participants With Advanced Solid Tumors.

for
Advanced Solid Tumors
Location: Boston MA, Fairfax VA, Lake Mary FL, Denver CO,
Sponsor: Eikon Therapeutics

Sex: All

Age: 18 - 70+

Code: NCT06907043

Phase1, Phase2, Recruiting

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

for
Advanced Solid Tumor, Advanced Malignant Neoplasm,
Location: Boston MA, New Haven CT, New York NY, Philadelphia PA,
Sponsor: PMV Pharmaceuticals, Inc

Sex: All

Age: 12+

Code: NCT04585750

Phase1, Phase2, Recruiting

A Study of XB628 Alone and in Combination With Zanzalintinib in Participants With Recurrent Advanced or Metastatic Solid Tumors

for
Solid Tumor, Advanced Solid Tumor, Metastatic Solid Tumor,
Location: Boston MA, New Haven CT, New York NY, Hickory NC,
Sponsor: Exelixis

Sex: All

Age: 18+

Code: NCT06952010

Phase1, Recruiting