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Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

for
Endometrial Cancer, Gastric Cancer,
Location: Commack NY, East Brunswick NJ, Columbus OH,
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT05489211

Phase2, Recruiting

Phase 1 Safety Study of ACT-PFK-158, 2HCl in Patients With Advanced Solid Malignancies

for
Cancer
Location: Washington DC, Louisville KY, Houston TX,
Sponsor: Advanced Cancer Therapeutics

Sex: All

Age: 18+

Code: NCT02044861

Phase1, Recruiting

Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

for
Clinical Stage III Cutaneous Melanoma AJCC v8,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06075524

Recruiting

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

for
Advanced Anal Carcinoma, Advanced Biliary Tract Carcinoma,
Location: Jacksonville FL, Grand Forks ND
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05969860

Phase2, Recruiting

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

for
Breast Cancer, Biliary Tract Carcinoma, Ovarian Cancer,
Location: Boston MA, Commack NY, Baltimore MD, Ottawa, Toronto,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT05123482

Phase1, Phase2, Recruiting

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A Study to Test How Well Different Doses of BI 3820768 Are Tolerated by People With Advanced Cancer (Solid Tumours)

for
Advanced Relapsed or Refractory Germ Cell Tumours,
Location: Houston TX, Los Angeles CA
Sponsor: Boehringer Ingelheim

Sex: All

Age: 18+

Code: NCT07306559

Phase1, Recruiting

First in Human Study to Evaluate AZD9793 in Participants With Advanced or Metastatic Solid Tumours

for
Hepatocellular Carcinoma
Location: St Louis MO, Houston TX, Los Angeles CA
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT06795022

Phase1, Phase2, Recruiting

Study of AZD4956 as Monotherapy and in Combination With Anti-Cancer Agents in Participants With Advanced/Metastatic Homologous Recombination Deficient Solid Tumours

for
Solid Tumours
Location: New York NY, Fairfax VA, Houston TX
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT07446855

Phase1, Phase2, Recruiting

Natural History of Medullary Thyroid Cancer to Inform Advanced Disease Management

for
Advanced Thyroid Gland Medullary Carcinoma,
Location: Houston TX, San Francisco CA
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04216732

Recruiting

Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations

for
Solid Tumours
Location: New Haven CT, New York NY, Montreal, Wynnewood PA,
Sponsor: Boehringer Ingelheim

Sex: All

Age: 18+

Code: NCT06581432

Phase2, Recruiting

Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT05098210

Phase1, Recruiting

A Study of BI 3810944 in Patients With Advanced Cancer

for
Solid Tumours, Melanoma
Location: Louisville KY, Nashville TN
Sponsor: Boehringer Ingelheim

Sex: All

Age: 18+

Code: NCT07224425

Phase1, Recruiting

Electronic Patient Reporting of Symptoms and Unmet Needs to Connect Patients With Advanced Cancer to Palliative Care Services

for
Palliative Care Referral, Advanced Cancer,
Location: Lebanon NH
Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All

Age: 18+

Code: NCT07195513

Recruiting

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

for
Advanced Esophageal Squamous Cell Carcinoma,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06265285

Phase2, Recruiting
Featured

A Study to Assess Adverse Events and Change in Disease Activity in Participants 12 Years of Age or Older With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification Receiving Intravenously Infused Telisotuzumab Adizutecan

for
Solid Tumors Harboring MET Amplification
Location: New Haven CT, New York NY, Fairfax VA, Durham NC,
Sponsor: AbbVie

Sex: All

Age: 12+

Code: NCT07196644

Phase2, Recruiting
Active & Responsive

A Study of YL201 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Boston MA, New York NY, Washington D.C. DC, Fairfax VA,
Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All

Age: 18+

Code: NCT05434234

Phase1, Phase2, Recruiting

Phase 1 Study of ACR-2316 in Specific Advanced Solid Tumors

for
Specific Advanced Solid Tumors
Location: Boston MA, Providence RI, The Bronx NY, Fairfax VA,
Sponsor: Acrivon Therapeutics

Sex: All

Age: 18+

Code: NCT06667141

Phase1, Recruiting

A Study of MGC028 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors, NSCLC Adenocarcinoma, Cholangiocarcinoma,
Location: Boston MA, New York NY, Grand Rapids MI, San Antonio TX,
Sponsor: MacroGenics

Sex: All

Age: 18+

Code: NCT06723236

Phase1, Recruiting

A Phase I/II, Open-label Study to Investigate the Safety, Tolerability, PK, and Preliminary Efficacy of FB849

for
Advanced Solid Tumor
Location: Fairfax VA, Cleveland OH, Dallas TX, San Antonio TX,
Sponsor: 1ST Biotherapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05761223

Phase1, Phase2, Recruiting

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

for
Advanced Solid Tumor Cancer
Location: Boston MA, Providence RI, New Haven CT, New York NY,
Sponsor: Calico Life Sciences LLC

Sex: All

Age: 18+

Code: NCT04777994

Phase1, Recruiting