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MRE Scan for the Assessment of Differences in Tissue Stiffness Between Radiation Necrosis and Recurrent Glioma in Patients With Previously Treated Gliomas

for
Glioma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04373720

Recruiting

The Feasibility and Efficacy of Dose Timing (Morning vs Evening) of Temozolomide in the Treatment of Glioblastoma

for
IDH-Wildtype Glioblastoma, Glioblastoma (GBM)
Location: Ottawa, London
Sponsor: Ottawa Hospital Research Institute

Sex: All

Age: 18+

Code: NCT06850766

Recruiting

Combination Therapy for the Treatment of Diffuse Midline Gliomas

for
Diffuse Intrinsic Pontine Glioma,
Location: Boston MA, New York NY, Hackensack NJ, Philadelphia PA,
Sponsor: University of California, San Francisco

Sex: All

Age: 2 - 39

Code: NCT05009992

Phase2, Recruiting

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

for
H3 K27M, Glioma
Location: Montreal, Ottawa, Toronto, London, Calgary, Vancouver
Sponsor: Jazz Pharmaceuticals

Sex: All

Age: 0+

Code: NCT05580562

Phase3, Recruiting

A Pilot Study Investigating Upfront Adaptive Immunotherapy Approach in Children, Adolescent and Young Adult (CAYA) Patients With Replication-Repair Deficient (RRD) High-Grade Gliomas (HGG)

for
High Grade Glioma, Replication Repair Deficient
Location: Toronto
Sponsor: Daniel Morgenstern

Sex: All

Age: 1 - 25

Code: NCT06519682

Recruiting

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B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Recurrent Glioblastoma Multiforme

for
Brain and Nervous System
Location: Palo Alto CA
Sponsor: Stanford University

Sex: All

Age: 18+

Code: NCT05474378

Phase1, Recruiting
New

A Phase1 Clinical Trial Evaluating Locoregional Delivery Of Engineered NK Cells Containing IL13Ra And EGFvIII Chimeric Antigen Receptor (CAR), IL-21 Secretion And Deleted TGF-BetaR2 And NR3C1 In Recurrent Glioblastoma

for
Phase 1, NK Cell, IL13Ra, EGFRvIII,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT07579208

Phase1, Recruiting

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

for
Central Nervous System Neoplasms, Glioblastoma,
Location: Bethesda MD
Sponsor: Jazz Pharmaceuticals

Sex: All

Age: 18+

Code: NCT04541082

Phase1, Recruiting

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

for
Cervical Cancer, Breast Cancer, Colon Cancer, NSCLC,
Location: Glen Burnie MD, Lexington KY, Omaha NE
Sponsor: Orano Med Theranostics, SAS

Sex: All

Age: 18+

Code: NCT05283330

Phase1, Recruiting

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

for
Advanced Malignant Solid Neoplasm, RAS Mutation, Lung Cancer,
Location: Nashville TN, Denver CO, Los Angeles CA
Sponsor: RasCal Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT04678648

Phase1, Recruiting

Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas

for
Anaplastic Astrocytoma, IDH-Wildtype,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04623931

Phase2, Recruiting

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

for
Advanced Anal Carcinoma, Advanced Biliary Tract Carcinoma,
Location: Jacksonville FL, Grand Forks ND
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05969860

Phase2, Recruiting

Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

for
Recurrent Astrocytoma, IDH-Mutant, Grade 3,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT06815029

Phase1, Recruiting

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

for
Amyloidosis, Basal Cell Carcinoma, Biliary Tract Carcinoma,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT07285044

Phase2, Recruiting

Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas

for
Anaplastic Oligodendroglioma, Astrocytoma, IDH-Mutant, Grade 3,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT07468136

Phase1, Phase2, Recruiting

Investigating the Feasibility and Acceptability of an Innovative Interdisciplinary Supportive Care Program: Couples Coping Together Against Cancer

for
Anatomic Stage IV Breast Cancer AJCC v8, Glioblastoma,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07664579

Recruiting

Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

for
Astrocytoma, IDH-Mutant, Grade 2,
Location: New Haven CT, Trumbull CT, Mineola NY, New York NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06860594

Phase1, Recruiting

Efineptakin Alfa and Pembrolizumab for the Treatment of Recurrent Glioblastoma

for
High Grade Astrocytic Tumor,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05465954

Phase2, Recruiting

Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling

for
Recurrent Childhood Acute Myeloid Leukemia,
Location: Miami FL
Sponsor: Florida International University

Sex: All

Age: 0 - 21

Code: NCT05857969

Phase1, Recruiting

Development of MRF for Characterization of Brain Tumors After Radiotherapy

for
Brain Tumor, Brain Necrosis, Brain Metastases, Glioma
Location: Cleveland OH
Sponsor: Case Comprehensive Cancer Center

Sex: All

Age: 18 - 60

Code: NCT06101069

Recruiting