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PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

for
Glioma, Medulloblastoma, Ependymoma, Glioblastoma
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06161519

Phase1, Phase2, Recruiting

18F-Fluciclovine PET-MRI in High-grade Glioma

for
Glioma, High Grade Glioma, Glioma, Malignant,
Location: Philadelphia PA
Sponsor: Children's Hospital of Philadelphia

Sex: All

Age: 1 - 21

Code: NCT05553041

Early_phase1, Recruiting

OPTIMUS PRIME: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial

for
Recurrent Glioblastoma
Location: Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 18 - 70+

Code: NCT06558214

Phase2, Recruiting

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

for
High Grade Glioma, Meningioma, Embryonal Tumor, Medulloblastoma,
Location: Columbus OH, Cincinnati OH
Sponsor: Nationwide Children's Hospital

Sex: All

Age: 4 - 39

Code: NCT05278208

Phase1, Phase2, Recruiting

Neoadjuvant Chemoimmunotherapy in Recurrent Glioblastoma

for
Glioblastoma
Location: Louisville KY
Sponsor: University of Louisville

Sex: All

Age: 18+

Code: NCT05700955

Phase1, Recruiting

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Investigator-Initiated Study of Imipramine Hydrochloride and Lomustine in Recurrent Glioblastoma

for
Glioblastoma
Location: San Antonio TX
Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All

Age: 0+

Code: NCT04863950

Phase2, Recruiting

Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Trial

for
Diffuse Midline Glioma, H3 K27M-Mutant
Location: Rochester MN, Phoenix AZ
Sponsor: Mayo Clinic

Sex: All

Age: 1+

Code: NCT05077735

Phase2, Recruiting

Customized Neuro-Imaging Referenced Symptom Video for the Reduction of Patient and Caregiver Anxiety Around Radiation Treatment for Brain Tumors

for
Glioblastoma, WHO Grade II Glioma, WHO Grade III Glioma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04479696

Recruiting

DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma

for
High Grade Glioma, MGMT-Unmethylated Glioblastoma,
Location: Lake Success NY, Miami FL, San Diego CA, Los Angeles CA,
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT06504381

Phase1, Phase2, Recruiting

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

for
High Grade Glioma, Diffuse Intrinsic Pontine Glioma,
Location: Washington D.C. DC, Durham NC, Miami FL, Columbus OH,
Sponsor: Nationwide Children's Hospital

Sex: All

Age: 3 - 39

Code: NCT05096481

Phase2, Recruiting

Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

for
Ependymoma, Medulloblastoma, Glioblastoma, Primary Brain Tumor
Location: Augusta GA
Sponsor: Theodore S. Johnson

Sex: All

Age: 3 - 25

Code: NCT05106296

Phase1, Recruiting

A Study Utilizing Escitalopram in Glioma Patients

for
Glioma of Brain, Glioma
Location: Omaha NE
Sponsor: University of Nebraska

Sex: All

Age: 19+

Code: NCT03728673

Phase2, Recruiting

A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial

for
Recurrent Glioblastoma
Location: Durham NC, Salt Lake City UT, San Francisco CA
Sponsor: Duke University

Sex: All

Age: 18+

Code: NCT06069726

Phase2, Recruiting

SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma

for
Low-Grade Glioma, Recurrent Low-Grade Glioma,
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 2 - 24

Code: NCT04923126

Phase1, Phase2, Recruiting

Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

for
Glioblastoma, Anaplastic Astrocytoma,
Location: New York NY
Sponsor: Northwell Health

Sex: All

Age: 18+

Code: NCT02800486

Phase2, Recruiting

MRI in High-Grade Glioma Patients Undergoing Chemoradiation

for
High Grade Glioma
Location: Winston-Salem NC
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 18+

Code: NCT05212272

Recruiting

Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

for
Glioma, Low-grade Glioma, Low Grade Glioma of Brain,
Location: Philadelphia PA
Sponsor: Children's Hospital of Philadelphia

Sex: All

Age: 1 - 21

Code: NCT05555550

Early_phase1, Recruiting

CARv3-TEAM-E T Cells in Glioblastoma

for
Glioblastoma, Malignant Glioma, Recurrent Glioblastoma,
Location: Boston MA
Sponsor: Marcela V. Maus, M.D.,Ph.D.

Sex: All

Age: 18+

Code: NCT05660369

Phase1, Recruiting

A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

for
Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype,
Location: New York NY, Chicago IL, Houston TX, Dallas TX,
Sponsor: Debiopharm International SA

Sex: All

Age: 18+

Code: NCT05765812

Phase1, Phase2, Recruiting

Telehealth Visits to Discuss Advanced Directives for Patients Newly Diagnosed With High Grade Glioma

for
Glioma
Location: Rochester NY
Sponsor: University of Rochester

Sex: All

Age: 18+

Code: NCT04543201

Recruiting