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A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

for
Chronic Lymphocytic Leukemia (CLL),
Location: Bethesda MD, Nashville TN, Chicago IL, Houston TX,
Sponsor: Nurix Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT04830137

Phase1, Recruiting

Acalabrutinib, Venetoclax and Durvalumab for the Treatment of Richter Transformation From Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

for
Chronic Lymphocytic Leukemia, Richter Syndrome,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05388006

Phase2, Recruiting

Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects

for
Chronic Lymphocytic Leukemia, Monoclonal B-Cell Lymphocytosis
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 40+

Code: NCT06536452

Recruiting

Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

for
Chronic Lymphocytic Leukaemia,
Location: Philadelphia PA, Columbus OH
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT06651970

Recruiting

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

for
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Location: Norwich CT, Hackensack NJ, Albany NY, Montreal,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06136559

Phase3, Recruiting

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Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment

for
Hairy Cell Leukemia (HCL), Chronic Lymphocytic Leukemia (CLL),
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT01087333

Recruiting

Multi-center Trial of Revlimid® and Rituximab, for First-Line Treatment of Chronic Lymphocytic Leukemia (CLL)

for
Chronic Lymphocytic Leukemia, CLL, Untreated, Front-line,
Location: Boston MA, New Hyde Park NY, Houston TX, La Jolla CA
Sponsor: Chronic Lymphocytic Leukemia Research Consortium

Sex: All

Age: 0+

Code: NCT00628238

Phase2, Recruiting

Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax

for
Chronic Lymphocytic Leukemia (CLL),
Location: Bethesda MD
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All

Age: 18 - 70+

Code: NCT05724121

Recruiting

Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

for
Chronic Lymphocytic Leukemia
Location: Bethesda MD
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All

Age: 18 - 70+

Code: NCT03986034

Phase2, Recruiting

Long-term Follow-up Study of Patients Receiving CAR-T Cells

for
Chronic Lymphocytic Leukemia, Lymphomas Non-Hodgkin's B-Cell,
Location: Milwaukee WI
Sponsor: Medical College of Wisconsin

Sex: All

Age: 18 - 70+

Code: NCT03375619

Recruiting

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

for
Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma,
Location: Boston MA, Providence RI, New York NY, Hackensack NJ,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT06564038

Phase1, Phase2, Recruiting

The Effects of Exercise on Immune Phenotype of Indolent Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia Patients

for
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma,
Location: Rochester MN, Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 70+

Code: NCT05876923

Recruiting

Economic Analysis of Early vs Delayed Therapy in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma:

for
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Location: Saint John, Montreal, Ottawa, Winnipeg, Vancouver
Sponsor: Canadian Cancer Trials Group

Sex: All

Age: 18+

Code: NCT05371808

Recruiting

Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

for
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Location: Rochester MN, Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT03516617

Phase2, Recruiting

Pirtobrutinib (LOXO-305) and Venetoclax for the Treatment of Patients With CLL or SLL Resistant to Covalent BTKi

for
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Location: Columbus OH
Sponsor: Kerry Rogers

Sex: All

Age: 18+

Code: NCT06466122

Phase2, Recruiting

Acalabrutinib in Combination With Venetoclax for the Treatment of Refractory or Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, The AVENUE-2 Trial

for
Recurrent Chronic Lymphocytic Leukemia,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT04941716

Phase2, Recruiting

CLIC-2201 for the Treatment of Relapsed/Refractory B Cell Malignancies

for
B-Cell Leukemia, Non-Hodgkin's Lymphoma,
Location: Ottawa, Toronto, Calgary, Vancouver
Sponsor: British Columbia Cancer Agency

Sex: All

Age: 1+

Code: NCT06208735

Phase1, Recruiting

Anti-pneumococcal Vaccine Strategy in Patients With Chronic Lymphocytic Leukemia

for
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Location: Columbus OH
Sponsor: Seema Bhat

Sex: All

Age: 18+

Code: NCT05417165

Phase2, Recruiting

AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma

for
B-cell Malignancy, Chronic Lymphocytic Leukemia,
Location: Worcester MA, Westbury NY, Baltimore MD, Durham NC,
Sponsor: Carna Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT05602363

Phase1, Recruiting

Trivalent CAR-T Cell in Acute B-Lineage Leukemia (TRICAR-ALL)

for
Leukemia, B-Cell
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 1 - 25

Code: NCT05010564

Phase1, Recruiting