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Antiminor Histocompatibility Complex (MiHA) T Cells for Patients With Relapsed Hematologic Malignancies Following Matched HSCT (Guided Lymphocyte Immunopeptide Derived Expansion)

for
Hematologic Cancer, Relapse Leukemia, Relapsed Adult ALL,
Location: Montreal
Sponsor: Ciusss de L'Est de l'Île de Montréal

Sex: All

Age: 18 - 65

Code: NCT03091933

Phase1, Phase2, Recruiting

Optimizing ctDNA-based MRD Assessment in DLBCL, MCL, and FL Patients Undergoing CAR Therapy

for
Follicular Lymphoma, Diffuse Large B Cell Lymphoma,
Location: Palo Alto CA
Sponsor: Adaptive Biotechnologies

Sex: All

Age: 18+

Code: NCT05255354

Recruiting

Cardiovascular Events Among Adults Patients With Relapsed or Refractory Aggressive B-Cell Lymphoma Treated With Standard of Care Chimeric Antigen Receptor T Cell Therapy

for
Recurrent Aggressive B-Cell Non-Hodgkin Lymphoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04870853

Recruiting

Allogeneic NK T-Cells Expressing CD19 Specific CAR in B-Cell Malignancies

for
NHL, Relapsed, Adult, B-cell Lymphoma, B-cell Leukemia,
Location: Houston TX, Portland OR, San Francisco CA
Sponsor: Athenex, Inc.

Sex: All

Age: 3 - 70+

Code: NCT05487651

Phase1, Recruiting

A Non-interventional, International, Multicentre Clinical Research Study to Build the Largest Collection of Multimodal Data (Including Clinical Data, Imaging Data and Omics Data) in Oncology

for
Diffuse Large B Cell Lymphoma, Solid Tumor Cancer
Location: Pittsburgh PA
Sponsor: OWKIN

Sex: All

Age: 18+

Code: NCT06625203

Recruiting

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A Study of Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Treated With Lisocabtagene Maraleucel in the Post-Marketing Setting

for
Chronic Lymphocytic Leukemia (CLL),
Location: Milwaukee WI
Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All

Age: 18+

Code: NCT06788639

Recruiting
New

Vorasidenib Maintenance for IDH Mutant Astrocytoma

for
IDH-mutant Grade 2 or 3 Astrocytoma
Location: Winnipeg
Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All

Age: 18+

Code: NCT06809322

Phase3, Recruiting
New

Study of NXP900 With Lorlatinib in ALK+ Lung Cancer

for
ALK Positive, ALK Positive Non-small Cell Lung Cancer, NSCLC,
Location: Fairfax VA
Sponsor: Nuvectis Pharma, Inc.

Sex: All

Age: 0+

Code: NCT07784959

Phase1, Recruiting
New

Chimeric Antigen Receptor Treatment Targeting CD70 (SEVENTY)

for
Leukemia, Myeloid, Acute, Leukemia, B-cell, Leukemia, T-Cell
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 0 - 70+

Code: NCT06345027

Phase1, Recruiting
New

Anti-CRLF2-R/TSLPR Chimeric Antigen Receptor T Cells (TSLPR-CART) in Participants With Recurrent or Refractory CRLF2-R/TSLPR-Overexpressing B-Cell Acute Lymphoblastic Leukemia (B-ALL)

for
B-All, Acute Lymphoblastic Leukemia
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT07572136

Phase1, Recruiting
New

A First-in-Human Study of KK2223 in Participants With Relapsed or Refractory T Cell Non-Hodgkin Lymphoma

for
T-cell NHL (PTCL or CTCL)
Location: New York NY, St Louis MO, Houston TX, Stanford CA
Sponsor: Kyowa Kirin, Inc.

Sex: All

Age: 18+

Code: NCT07192471

Phase1, Recruiting

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

for
Advanced Systemic Mastocytosis (AdvSM),
Location: Boston MA, Charleston SC, Toronto, Atlanta GA,
Sponsor: Cogent Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT04996875

Phase2, Recruiting

Daratumumab for Chemotherapy-Refractory Minimal Residual Disease in T Cell ALL

for
T-cell Acute Lymphoblastic Leukemia
Location: Chicago IL
Sponsor: Eastern Cooperative Oncology Group

Sex: All

Age: 18+

Code: NCT05289687

Phase2, Recruiting

Combining Topical Imiquimod With Local Radiotherapy for Treatment of Mycosis Fungoides

for
Mycosis Fungoides
Location: Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18 - 70+

Code: NCT05838599

Early_phase1, Recruiting

Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 2 - 22

Code: NCT06128070

Phase2, Recruiting

Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects

for
Chronic Lymphocytic Leukemia, Monoclonal B-Cell Lymphocytosis
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 40+

Code: NCT06536452

Recruiting

Orphan Indications for CD19 Redirected Autologous T Cells

for
Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALL,
Location: Philadelphia PA
Sponsor: Stephan Grupp MD PhD

Sex: All

Age: 0 - 29

Code: NCT04276870

Phase2, Recruiting

Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

for
Chronic Lymphocytic Leukaemia,
Location: Philadelphia PA, Columbus OH
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT06651970

Recruiting

Avera Cancer Sequencing and Analytics Protocol (ASAP)

for
Cancer, Cancer Diagnosis, Early Detection of Cancer,
Location: Marshall MN, Sioux Falls SD, Yankton SD, Mitchell SD,
Sponsor: Avera McKennan Hospital & University Health Center

Sex: All

Age: 18+

Code: NCT05142033

Recruiting

Intrathecal Chemoprophylaxis to Prevent Neurotoxicity Associated With Blinatumomab Therapy for Acute Lymphoblastic Leukemia

for
Acute Lymphoblastic Leukemia
Location: Atlanta GA
Sponsor: Northside Hospital, Inc.

Sex: All

Age: 18+

Code: NCT05519579

Phase2, Recruiting