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Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

for
Glioblastoma, GBM
Location: Boston MA, Long Island City NY, New York NY, Albany NY,
Sponsor: Alpheus Medical, Inc.

Sex: All

Age: 18 - 70+

Code: NCT07225621

Phase2, Recruiting

hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM)

for
Glioblastoma Multiforme, Glioblastoma Multiforme, Adult,
Location: Cleveland OH
Sponsor: Leland Metheny

Sex: All

Age: 18+

Code: NCT05052957

Phase2, Recruiting

Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent Glioblastoma

for
Glioblastoma
Location: Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT07145112

Phase1, Recruiting

Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures

for
Meningioma, Glioblastoma, Acoustic Neuroma, Brain Cancer,
Location: Nashville TN
Sponsor: Eben Rosenthal

Sex: All

Age: 18+

Code: NCT07493447

Early_phase1, Recruiting

Study of How Safe and Effective Tarlatamab is in Brain Cancers

for
Astrocytic Tumor, Oligodendroglial Tumor
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT06776250

Phase2, Recruiting

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Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial

for
Glioblastoma (GBM)
Location: South Weymouth MA, Boston MA, Milford MA
Sponsor: Brigham and Women's Hospital

Sex: All

Age: 65+

Code: NCT06835803

Phase2, Recruiting

Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

for
Glioblastoma Multiforme
Location: Los Angeles CA
Sponsor: Chirag G. Patil

Sex: All

Age: 18+

Code: NCT04977375

Phase1, Phase2, Recruiting

Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

for
Recurrent Astrocytoma, IDH-Mutant, Grade 4,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07544992

Phase1, Recruiting

GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma

for
Glioblastoma, IDH-Wildtype,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT07301268

Phase2, Recruiting

Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma

for
Progressive Glioblastoma, Recurrent Glioblastoma
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT07076472

Early_phase1, Recruiting

Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies

for
Sarcoma, Endocrine Tumors, Neuroblastoma, Retinoblastoma,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 0+

Code: NCT01109394

Recruiting

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

for
Melanoma, Medullary Thyroid Cancer,
Location: Tucson AZ, Seattle WA
Sponsor: University of Arizona

Sex: All

Age: 18 - 70+

Code: NCT06814496

Phase1, Phase2, Recruiting

A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas

for
Glioblastoma, Brain Tumor
Location: Cleveland OH
Sponsor: Case Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT07003542

Phase2, Recruiting

G-CSF After Chemo-radiation in Patients With Glioblastoma

for
MGMT-Methylated Glioblastoma, Glioblastoma (GBM),
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18+

Code: NCT06649851

Phase2, Recruiting

ABY-029 Glioma Trial

for
Intracranial Tumor
Location: Lebanon NH
Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All

Age: 18+

Code: NCT07063693

Phase1, Recruiting

UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-4

for
Glioblastoma (GBM), Astrocytoma, Grade IV
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18+

Code: NCT07459101

Recruiting

Tamoxifen Versus Etoposide After First Recurrence in GBM Patients

for
Glioblastoma Multiforme
Location: Edmonton
Sponsor: AHS Cancer Control Alberta

Sex: All

Age: 18 - 65

Code: NCT04765098

Phase2, Recruiting

Retinoblastoma Patient Clinical Database and Tissue Repository

for
Retinoblastoma, Retinoblastoma Bilateral,
Location: Philadelphia PA, Toronto, Atlanta GA, Chicago IL,
Sponsor: Children's Hospital Los Angeles

Sex: All

Age: 0 - 18

Code: NCT04959097

Recruiting

D2C7-IT + 2141-V11 Combination Post-resection in rGBM

for
Recurrent Glioblastoma IDH Wildtype
Location: Durham NC
Sponsor: Darell Bigner

Sex: All

Age: 18+

Code: NCT06455605

Phase1, Recruiting

HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM

for
Glioblastoma, Anaplastic Astrocytoma
Location: Houston TX
Sponsor: The Methodist Hospital Research Institute

Sex: All

Age: 18+

Code: NCT03603405

Phase1, Phase2, Recruiting