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RP1 in Primary Melanoma to Reduce the Risk of Sentinel Lymph Node Metastasis

for
Melanoma
Location: Pittsburgh PA
Sponsor: Yana Najjar

Sex: All

Age: 18+

Code: NCT06216938

Early_phase1, Recruiting

BostonGene and Exigent Genomic INsight Study

for
Breast Cancer, Non-small Cell Lung Cancer, Melanoma, Sarcoma
Location: Fort Wayne IN, Rogers AR, Houston TX, Tulsa OK,
Sponsor: BostonGene

Sex: All

Age: 18+

Code: NCT06272864

Recruiting

Study of the Efficacy of Intratumoral L19IL2 or L19TNF or L19IL2/L19TNF, in Combination With Pembrolizumab, in Unresectable Melanoma Patients

for
Melanoma Stage III, Melanoma Stage IV
Location: Hartford CT, New York NY
Sponsor: Philogen S.p.A.

Sex: All

Age: 18+

Code: NCT06284590

Phase2, Recruiting

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

for
Diffuse Astrocytoma, IDH-Mutant, Glioblastoma, IDH-wildtype,
Location: Boston MA, Boynton Beach FL, Nashville TN, Dallas TX,
Sponsor: Neonc Technologies, Inc.

Sex: All

Age: 18+

Code: NCT06047379

Phase1, Phase2, Recruiting

Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

for
Melanoma
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 18

Code: NCT02775643

Recruiting

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Digital Remote Monitoring of Immune Checkpoint Inhibitor Therapy Induced Toxicity Using the Vigilant App

for
Malignant Skin Neoplasm, Melanoma
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06675643

Recruiting

Ontario-wide Cancer TArgeted Nucleic Acid Evaluation

for
Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma,
Location: Ottawa, Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT02906943

Recruiting

The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

for
Actinic Keratoses, Aging, Non-Melanoma Skin Cancer
Location: Fairborn OH
Sponsor: Wright State University

Sex: All

Age: 60+

Code: NCT06428721

Recruiting

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

for
Non Small Cell Lung Cancer, Triple Negative Breast Cancer,
Location: Boston MA, Buffalo NY, Orlando FL, Sarasota FL,
Sponsor: Compass Therapeutics

Sex: All

Age: 18+

Code: NCT06150664

Phase1, Recruiting

A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab

for
Melanoma
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT02621021

Phase2, Recruiting

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

for
Pediatric Solid Tumor, Osteosarcoma, Rhabdomyosarcoma,
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 21

Code: NCT04897321

Phase1, Recruiting

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

for
Breast Cancer, Sarcoma, Gastric Cancer, Lung Cancer,
Location: Orange CA
Sponsor: University of California, Irvine

Sex: All

Age: 18+

Code: NCT06580002

Phase2, Recruiting

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

for
Healthy Volunteer, Prostate Cancer, Head and Neck Cancer,
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT04354064

Recruiting

Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

for
Cancer, Solid Tumor, Melanoma, Renal Cell Carcinoma,
Location: Boston MA, New Haven CT, Buffalo NY, Tampa FL,
Sponsor: Simcha IL-18, Inc.

Sex: All

Age: 18+

Code: NCT04787042

Phase1, Phase2, Recruiting

A Storage Facility for Tissues Obtained From Patients With Malignant Melanoma

for
Melanoma
Location: Columbus OH
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 0+

Code: NCT04567706

Recruiting

Duration of Anti-PD-1 Therapy in Metastatic Melanoma

for
Unresectable/Metastatic Melanoma
Location: Fredericton, Montreal, Ottawa, Kingston, Oshawa,
Sponsor: Canadian Cancer Trials Group

Sex: All

Age: 18+

Code: NCT02821013

Phase3, Recruiting

A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

for
Metastatic Uveal Melanoma
Location: Boston MA, New York NY, Philadelphia PA,
Sponsor: Replimune Inc.

Sex: All

Age: 0+

Code: NCT06581406

Phase2, Phase3, Recruiting

Quality of Life, Lifestyle, and Psychosocial Factors in Patients With Melanoma

for
Cutaneous Melanoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04778449

Recruiting

Pembrolizumab and Hypofractionated Radiation Therapy for the Treatment of Mucosal Melanoma

for
Mucosal Melanoma of the Head and Neck
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 16+

Code: NCT04318717

Phase2, Recruiting

Fecal Microbiota Transplantation in Treating Immune-Checkpoint Inhibitor Induced-Diarrhea or Colitis in Genitourinary Cancer Patients

for
Colitis, Diarrhea, Malignant Genitourinary System Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04038619

Phase1, Recruiting