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Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

for
Advanced Solid Tumors, Metastatic Pancreatic Cancer,
Location: Bethesda MD, Fairway KS
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 12 - 70+

Code: NCT04222413

Phase1, Recruiting

Microbiotic Product to Promote Microbiome Health and Improve Chemotherapy Delivery

for
Metastatic Colon Carcinoma, Stage IV Colon Cancer AJCC v8,
Location: Toms River NJ, Lakewood NJ, Newark NJ, Livingston NJ,
Sponsor: Howard S. Hochster, MD

Sex: All

Age: 18+

Code: NCT05296681

Phase2, Recruiting

Phase II Trial of Lung Chemoemobolization

for
Lung Non-Small Cell Carcinoma, Mediastinal Neoplasm,
Location: New York NY, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT05672108

Phase2, Recruiting

A Study of NX-1607 in Adults With Advanced Malignancies

for
Ovarian Cancer, Epithelial, Gastric Cancer,
Location: Charlottesville VA, Chapel Hill NC, Chicago IL,
Sponsor: Nurix Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05107674

Phase1, Recruiting

PRE-ISPY Phase I/II Oncology Platform Program

for
HER2-positive Breast Cancer, Metastatic Cancer,
Location: Birmingham AL, Chicago IL, Orland Park IL, New Lenox IL,
Sponsor: QuantumLeap Healthcare Collaborative

Sex: All

Age: 18+

Code: NCT05868226

Phase1, Phase2, Recruiting

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A Study of Sofe-M in Participants With Selected Advanced Solid Tumors

for
Ovarian Neoplasms, Endometrial Neoplasms,
Location: Mineola NY, New York NY, Columbus OH, Grand Rapids MI,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06400472

Phase1, Recruiting

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumors, HNSCC, SCLC, NSCLC,
Location: Boston MA, New York NY, New Haven CT, Miami FL, Toronto,
Sponsor: Tubulis GmbH

Sex: All

Age: 18+

Code: NCT06657222

Phase1, Phase2, Recruiting

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

for
Cervical Cancer, Breast Cancer, Colon Cancer, NSCLC,
Location: Glen Burnie MD, Lexington KY, Omaha NE
Sponsor: Orano Med Theranostics, SAS

Sex: All

Age: 18+

Code: NCT05283330

Phase1, Recruiting

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

for
Advanced Anal Carcinoma, Advanced Biliary Tract Carcinoma,
Location: Jacksonville FL, Grand Forks ND
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05969860

Phase2, Recruiting

Preoperative Ketogenic Diet for Reduction of Hepatic Steatosis

for
Liver Steatoses, Liver Metastasis Colon Cancer, NAFLD
Location: London
Sponsor: Anton Skaro

Sex: All

Age: 18+

Code: NCT05884723

Recruiting

Survivors Uniting for Remote Guided Exercise

for
Cancer,
Location: Fort Collins CO
Sponsor: Colorado State University

Sex: All

Age: 18+

Code: NCT07290309

Recruiting

A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors

for
Advanced or Metastatic Solid Tumors,
Location: San Antonio TX, Scottsdale AZ
Sponsor: SHY Therapeutics

Sex: All

Age: 18+

Code: NCT07705334

Phase1, Recruiting

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

for
Non-small Cell Lung Cancer, Colorectal Carcinoma,
Location: Boston MA, New York NY, Philadelphia PA, Pittsburgh PA,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT06218914

Phase1, Recruiting

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

for
Urothelial Carcinoma Bladder,
Location: New York NY, Glen Burnie MD, Miami FL, Pittsburgh PA,
Sponsor: Aktis Oncology, Inc.

Sex: All

Age: 18+

Code: NCT07020117

Phase1, Recruiting

A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors

for
ER+, HER 2- Breast Cancer, Non-small Cell Lung Cancer (NSCLC),
Location: Lake Success NY, East Brunswick NJ, Fairfax VA,
Sponsor: IDEAYA Biosciences

Sex: All

Age: 18 - 70+

Code: NCT07540572

Phase1, Recruiting

Intra-tumoral (IT) Injection of vvDD-hIL2-2-RG-1 for Metastatic Gastrointestinal and Peritoneal Tumors

for
Gastric Neoplasms, Esophageal Cancer, Liver Cancer,
Location: Pittsburgh PA
Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Sex: All

Age: 18 - 69

Code: NCT07001592

Phase1, Recruiting

Stereotactic Ablative Radiotherapy (SABR) for the Treatment of Patients With Metastatic Cancer, ID-COMET Trial

for
Oligometastasis, Lung Cancer, Colo-rectal Cancer,
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 1+

Code: NCT06563388

Phase3, Recruiting

ctDNA-Directed Post-Hepatectomy Chemotherapy for Patients With Resectable Colorectal Liver Metastases

for
Liver Metastases
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05062317

Phase2, Recruiting

Preoperative Y-90 Radioembolization for Tumor Control and Future Liver Remnant Hypertrophy in Patients With Colorectal Liver Metastases

for
Metastases
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05195710

Phase1, Recruiting
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A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer

for
Colorectal Cancer
Location: Lake Success NY, East Brunswick NJ, Seattle WA,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT07525206

Phase3, Recruiting