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Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

for
Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC),
Location: Boston MA, New York NY, Baltimore MD, Fairfax VA,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT05379985

Phase1, Phase2, Recruiting

Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

for
Bladder Cancer, Head and Neck Squamous Cell Carcinoma,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 18+

Code: NCT03740256

Phase1, Recruiting

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

for
Non-Small Cell Lung Cancer (NSCLC)
Location: Halifax, Worcester MA, Montreal, Media PA, Newark DE,
Sponsor: Amgen

Sex: All

Age: 18 - 70+

Code: NCT05920356

Phase3, Recruiting

Neoadjuvant Dupilumab and Cemiplimab in Patients With Early-stage Resectable NSCLC

for
Non-Small Cell Lung Cancer
Location: New York NY
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All

Age: 18+

Code: NCT06088771

Phase1, Phase2, Recruiting

Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International Registry

for
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Location: Ottawa, Miami FL, Tampa FL, Calgary, Seattle WA
Sponsor: Immune Oncology Research Institute

Sex: All

Age: 0+

Code: NCT05430971

Recruiting

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Trial Of Stereotactic Body Radiation Therapy (SBRT) for Oligoprogression on Immune Checkpoint Inhibitors (ICI) in Metastatic Renal Cell Carcinoma

for
Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma,
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 18+

Code: NCT04974671

Phase2, Recruiting

Talazoparib and Thoracic RT for ES-SCLC

for
Lung Cancer, Small-Cell Lung Cancer
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT04170946

Phase1, Recruiting

LOcally ABLatIve ThErapy for OligopRogressive Lung And Thoracic MalignanciEs (OBLITERATE)

for
Non-small Cell Lung Cancer, Oligoprogressive,
Location: Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT06103682

Recruiting

Study of XB010 in Subjects With Solid Tumors

for
Locally Advanced or Metastatic Solid Tumors,
Location: The Bronx NY, Washington D.C. DC, Fairfax VA,
Sponsor: Exelixis

Sex: All

Age: 18+

Code: NCT06545331

Phase1, Recruiting

PBF-1129 and Nivolumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

for
Metastatic Lung Non-Small Cell Carcinoma,
Location: Columbus OH
Sponsor: Dwight Owen

Sex: All

Age: 18+

Code: NCT05234307

Phase1, Recruiting

Study of Bevacizumab in Combination With Chemoimmunotherapy and Atezolizumab in Patients With Extensive Stage Small Cell Lung Cancer and Liver Metastases

for
Extensive-stage Small-cell Lung Cancer, Liver Metastases
Location: Ann Arbor MI, Los Angeles CA
Sponsor: Kamya Sankar

Sex: All

Age: 0+

Code: NCT05588388

Phase2, Recruiting

A Study of Radiation Therapy After Surgery in People With Oral Tongue Squamous Cell Carcinoma

for
Oral Tongue Squamous Cell Carcinoma
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06485778

Phase2, Recruiting

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for
Recurrent Lung Non-Small Cell Carcinoma,
Location: Brewer ME, Manchester NH, Worcester MA, Concord NH,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 0+

Code: NCT06031688

Phase2, Recruiting

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

for
Neoplasms, Brain, Glioblastoma Multiforme,
Location: Birmingham AL, St Louis MO, Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 3 - 22

Code: NCT03911388

Phase1, Recruiting

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumor, Melanoma, Head and Neck Cancer,
Location: New Haven CT, New York NY, Baltimore MD, Buffalo NY,
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT06172478

Phase2, Recruiting

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

for
Non-small Cell Lung Cancer, Anaplastic Lymphoma Kinase-positive
Location: Boston MA, Westbury NY, New York NY, Sellersville PA,
Sponsor: Nuvalent Inc.

Sex: All

Age: 18+

Code: NCT06765109

Phase3, Recruiting

ctDNA in Cutaneous Squamous Cell Carcinoma

for
Cutaneous Squamous Cell Carcinoma
Location: Boston MA
Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All

Age: 18+

Code: NCT06875609

Recruiting

A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

for
Non-small Cell Lung Cancer
Location: Commack NY, Uniondale NY, Mineola NY, Harrison NY,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06077760

Phase3, Recruiting

Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer

for
Extensive Stage Lung Small Cell Carcinoma,
Location: Columbus OH, Indianapolis IN, Chicago IL, Madison WI,
Sponsor: Dwight Owen

Sex: All

Age: 18+

Code: NCT04919382

Phase2, Recruiting

Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer

for
Advanced Lung Non-Small Cell Carcinoma,
Location: Irvine CA, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT06249282

Phase1, Recruiting