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Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

for
Advanced Breast Carcinoma, Advanced Endometrial Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05092373

Phase1, Recruiting

Study of [212Pb]Pb-DOTAM-MAM279 ([212Pb]Pb-MP0712) in Patients With Small Cell Lung Cancer and Other DLL3 Expressing Solid Tumors

for
Large Cell Neuroendocrine Carcinoma,
Location: Princeton NJ, Glen Burnie MD, Cleveland OH, Atlanta GA,
Sponsor: Molecular Partners AG

Sex: All

Age: 18+

Code: NCT07278479

Phase1, Phase2, Recruiting

Atezolizumab Plus Etoposide and Platinum in Small Cell Bladder Cancer

for
Small Cell Neuroendocrine Carcinoma of Bladder, Bladder Cancer,
Location: Baltimore MD, Washington D.C. DC
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18+

Code: NCT05312671

Phase2, Recruiting

A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

for
Metastatic Non-small Cell Lung Cancer
Location: Boston MA, Quebec, The Bronx NY, New York NY,
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT06417814

Phase3, Recruiting

Repositioning Immunotherapy in VetArans With Lung Cancer

for
Non-Small Cell Lung Cancer
Location: West Haven CT, Washington D.C. DC, Richmond VA,
Sponsor: VA Office of Research and Development

Sex: All

Age: 18+

Code: NCT06275360

Phase2, Recruiting

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Mosaic Trial for Stem Cell Transplant Recipients

for
Hematologic Malignancy, Stem Cell Transplant,
Location: Nutley NJ, Washington D.C. DC, Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT06960993

Recruiting

Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT

for
Germ Cell Tumor, Non-seminomatous Germ Cell Tumor,
Location: Indianapolis IN
Sponsor: Nabil Adra

Sex: All

Age: 18+

Code: NCT04804007

Phase2, Recruiting

ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer

for
Endometrial Cancer, Metastasis, Endometrioid Endometrial Cancer,
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female

Age: 18+

Code: NCT05542407

Phase1, Recruiting

Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)

for
Waldenstrom Macroglobulinemia, Lymphoplasmacytic Lymphoma,
Location: Bethesda MD
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All

Age: 18 - 70+

Code: NCT00923507

Recruiting

PUL-042 Treatment in Patients With Parainfluenza Virus (PIV), Human Metapneumovirus (hMPV) or Respiratory Syncytial Virus (RSV)

for
Hematologic Malignancies,
Location: Boston MA, Hackensack NJ, Baltimore MD, Chapel Hill NC,
Sponsor: Pulmotect, Inc.

Sex: All

Age: 18+

Code: NCT06665100

Phase2, Recruiting

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

for
Advanced Anal Carcinoma, Advanced Biliary Tract Carcinoma,
Location: Jacksonville FL, Grand Forks ND
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05969860

Phase2, Recruiting

Studies on Tumors of the Thyroid

for
Hurthle Cell Thyroid Cancer, Tall Cell Variant Thyroid Cancer,
Location: Bethesda MD
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All

Age: 0 - 70+

Code: NCT00001160

Recruiting

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

for
Advanced Esophageal Squamous Cell Carcinoma,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06265285

Phase2, Recruiting

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

for
Lung Cancer, Lung Cancer Metastatic, Brain Metastases,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05419076

Phase2, Recruiting

Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)

for
Non-Hodgkin Lymphoma, B-cell Acute Lymphoblastic Leukemia,
Location: Boston MA, Providence RI, New York NY, Baltimore MD,
Sponsor: Imugene Limited

Sex: All

Age: 18+

Code: NCT03666000

Phase1, Recruiting

Study of RYZ101 Compared With SOC in Pts w Inoperable SSTR+ Well-differentiated GEP-NET That Has Progressed Following 177Lu-SSA Therapy

for
GEP-NET, Gastroenteropancreatic Neuroendocrine Tumor,
Location: New York NY, Glen Burnie MD, Miami FL, Pittsburgh PA,
Sponsor: RayzeBio, Inc.

Sex: All

Age: 18+

Code: NCT05477576

Phase3, Recruiting

Cemiplimab and Fianlimab Before Surgery for the Treatment of Stage IB-IIIB Non-Small Cell Lung Cancer

for
Lung Non-Small Cell Carcinoma, Stage IB Lung Cancer AJCC v8,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06918132

Phase2, Recruiting

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

for
Carcinoma, Non-Small Cell Lung,
Location: Boston MA, Newton MA, Shirley NY, Riverhead NY,
Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All

Age: 18+

Code: NCT04389632

Phase1, Recruiting

A Study to Evaluate Zanubrutinib and Tislelizumab in Progressive Lymphoma Post CAR-T

for
Large B-cell Lymphoma
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT06167785

Phase2, Recruiting

Zimberelimab and Quemliclustat in Combination With Chemotherapy for the Treatment of Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma

for
Borderline Resectable Pancreatic Adenocarcinoma,
Location: Los Angeles CA
Sponsor: Jonsson Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT05688215

Phase1, Phase2, Recruiting