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A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

for
Non-small Cell Lung Cancer
Location: Halifax, Stamford CT, Trois-Rivieres, Albany NY,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06345729

Phase3, Recruiting

A Phase 1 Dose Escalation Study of ZG006 in Patients With Small Cell Lung Cancer

for
Small Cell Lung Cancer
Location: Plantation FL, Canton OH, Lexington KY
Sponsor: Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Sex: All

Age: 18 - 70+

Code: NCT06592638

Phase1, Recruiting

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

for
Metastatic Renal Cell Carcinoma,
Location: Boston MA, Quebec, Bay Shore NY, Commack NY,
Sponsor: NRG Oncology

Sex: All

Age: 18+

Code: NCT05327686

Phase2, Recruiting

Tumor Treating Fields for Locally Advanced NSCLC

for
Non Small Cell Lung Cancer
Location: Salt Lake City UT
Sponsor: University of Utah

Sex: All

Age: 22+

Code: NCT06124118

Phase1, Recruiting

Extracellular Vesicles and Particles (EVP) as Biomarkers of Recurrence in Non-Small Cell Lung Cancer

for
Non-Small Cell Lung Cancer
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05424029

Recruiting

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Dose-escalated Adaptive Radiotherapy of Thoracic Disease for Small Cell Lung Cancer

for
Small Cell Lung Cancer
Location: Edmonton
Sponsor: AHS Cancer Control Alberta

Sex: All

Age: 18+

Code: NCT04952480

Phase2, Recruiting

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

for
Carcinoma, Non-Small-Cell Lung,
Location: Montreal, Fairfax VA, Toronto, Cleveland OH, Detroit MI,
Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All

Age: 18+

Code: NCT05208762

Phase1, Recruiting

Zanubrutinib in Patients With DLBCL and MYD88 or NOTCH1 Mutation or CD5+

for
Diffuse Large B-cell Lymphoma,
Location: Richmond VA
Sponsor: Virginia Commonwealth University

Sex: All

Age: 18+

Code: NCT06846463

Phase2, Recruiting

Effectiveness and Performance of an Optical Biopsy Technology for Esophageal Cancer in Brazil and the United States

for
Suspected or Known Squamous Cell Neoplasia,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 18+

Code: NCT06435286

Phase2, Recruiting

Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

for
Childhood Extracranial Germ Cell Tumor,
Location: St. John's, Halifax, Bangor ME, Portland ME,
Sponsor: Children's Oncology Group

Sex: All

Age: 0+

Code: NCT03067181

Phase3, Recruiting

A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

for
Central Nervous System Nongerminomatous Germ Cell Tumor,
Location: Halifax, Bangor ME, Scarborough ME, Boston MA,
Sponsor: Children's Oncology Group

Sex: All

Age: 3 - 29

Code: NCT04684368

Phase2, Recruiting

Biology of Young Lung Cancer Study: The YOUNG LUNG Study

for
Non Small Cell Lung Cancer, Small Cell Lung Carcinoma,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 15+

Code: NCT05265429

Recruiting

Study of a Communication Training Intervention for Large B-Cell Lymphoma Providers

for
Lymphoma, B-Cell, Lymphoma, Large-cell Lymphoma,
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05940272

Recruiting

A Study to Investigate Safety and Effectiveness of Tacabrutideg (BGB-16673) in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

for
B-cell Malignancy, Relapsed Cancer, Refractory Cancer,
Location: New York NY, Philadelphia PA, Rochester NY,
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT06634589

Phase1, Phase2, Recruiting

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

for
Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
Location: Boston MA, Providence RI, Burlington MA, New Haven CT,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06119581

Phase3, Recruiting

Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects

for
Hematopoietic and Lymphoid Cell Neoplasm,
Location: Brewer ME, Boston MA, Providence RI, West Haven CT,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 0+

Code: NCT04242095

Recruiting

A Study of Hospital-at-Home for People Receiving Tarlatamab

for
Small-cell Lung Cancer, Small Cell Lung Carcinoma
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06957314

Recruiting

A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors

for
Melanoma (Skin), Non Small Cell Lung Cancer, Breast Cancer
Location: Farmington Hills MI, Indianapolis IN, Dallas TX,
Sponsor: Hummingbird Bioscience

Sex: All

Age: 18+

Code: NCT06956690

Phase1, Phase2, Recruiting

Study of Aerosolized Antibiotics and Pembrolizumab in Advanced Non-small Cell Lung Cancer

for
Advanced Non Small Cell Lung Cancer
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT05777603

Phase1, Recruiting

A Study to Evaluate the Efficacy and Safety of Sutetinib Maleate Capsule in Locally Advanced or Metastatic NSCLC

for
Non-small Cell Lung Cancer
Location: New York NY, Tampa FL, Athens GA, Des Moines IA,
Sponsor: Teligene US

Sex: All

Age: 18+

Code: NCT06010329

Phase2, Recruiting