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Active & Responsive

Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial

for
Glioblastoma, IDH-Wildtype
Location: Durham NC, Winston-Salem NC, Morgantown WV,
Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All

Age: 18+

Code: NCT06319027

Phase2, Recruiting
Active & Responsive

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

for
CNS Embryonal Tumor, CNS, Medulloblastoma,
Location: Quebec, Sherbrooke, Montreal, Toronto, Hamilton, London,
Sponsor: C17 Council

Sex: All

Age: 0 - 6

Code: NCT06942039

Early_phase1, Recruiting
Active & Responsive

Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors

for
Somatostatin Receptor Positive, NETs, Lymphoma, Solid Tumor,
Location: Philadelphia PA, Houston TX, San Francisco CA
Sponsor: ITM Solucin GmbH

Sex: All

Age: 2 - 18

Code: NCT06441331

Phase1, Recruiting
Active & Responsive

An Exercise Intervention for Improving Mental and Physical Health in Patients With Primary Brain Tumors and Their Caregivers, ET-NEURO Trial

for
Primary Brain Neoplasm
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT07278440

Recruiting
Active & Responsive

A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma

for
Multiple Myeloma in Relapse, Myeloma Multiple,
Location: Boston MA, Hackensack NJ, Tampa FL, Atlanta GA,
Sponsor: Kelonia Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07075185

Phase1, Recruiting

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Active & Responsive

A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant

for
Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive,
Location: Boston MA, Atlanta GA, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18 - 70+

Code: NCT07020533

Phase1, Recruiting
Active & Responsive

Ambient Sensing Room to Detect Early Signs of Adverse Events in Hospitalized Patients With Cancer

for
Hematopoietic and Lymphatic System Neoplasm,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT07477886

Recruiting
Active & Responsive

Intrathecal Cytarabine, Methotrexate, and Hydrocortisone for the Prevention of High-Grade Chimeric Antigen Receptor T-Cell-Associated Neurotoxicity Syndrome

for
Hematopoietic and Lymphatic System Neoplasm
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT06895473

Phase2, Recruiting
Active & Responsive

A Clinical Study of MK-4716 in People With Certain Solid Tumors (MK-4716-001)

for
Malignant Neoplasm
Location: Quebec, New Brunswick NJ, Montreal, Fairfax VA, Toronto,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07247110

Phase1, Recruiting
Active & Responsive

Evaluation of Early Identification of Cognitive Side Effects of Immunotherapy

for
Hematopoietic and Lymphatic System Neoplasm,
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 18+

Code: NCT06414278

Recruiting
Active & Responsive

KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

for
Malignant Neoplasm
Location: Clermont FL, Fargo ND, Sioux Falls SD
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07252739

Phase2, Recruiting
Active & Responsive

Constitutive IL7R (C7R) Modified Banked Allogeneic CD30.CAR EBVSTS for CD30-Positive Lymphomas

for
CD30-Positive Diffuse Large B-Cell Lymphoma,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 12 - 70+

Code: NCT06176690

Phase1, Recruiting
Active & Responsive

First-in Cancer-Type Phase I Study of FT536 for Recurrent WHO Grade 4 Astrocytoma

for
Astrocytoma, Glioblastoma, Progressive Disease
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 18 - 70+

Code: NCT07560865

Phase1, Recruiting
Active & Responsive

FH-FOLR1 Chimeric Antigen Receptor T Cell Therapy for Treating Pediatric Patients With Relapsed or Refractory Acute Myeloid Leukemia

for
Recurrent Childhood Acute Myeloid Leukemia,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 0 - 6

Code: NCT06609928

Phase1, Recruiting
Active & Responsive

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

for
Breast Neoplasms, Colorectal Neoplasms, Prostate Neoplasm,
Location: Boston MA, New York NY, Toronto, Hamilton, Tampa FL,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT07114601

Phase1, Recruiting
Active & Responsive

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

for
Neuroblastoma, Rhabdomyosarcoma, Synovial Sarcoma,
Location: Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 0 - 25

Code: NCT06625190

Phase1, Phase2, Recruiting
Active & Responsive

Tegavivint With Gemcitabine in Patients With Relapsed or Refractory Osteosarcoma

for
Osteosarcoma Recurrent, Osteosarcoma in Children,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 1 - 30

Code: NCT07144254

Phase1, Recruiting
Active & Responsive

CAR T Cells After Lymphodepletion for the Treatment of IL13Rα2 Positive Recurrent or Refractory Brain Tumors in Children

for
Malignant Brain Neoplasm, Recurrent Malignant Brain Neoplasm,
Location: Ann Arbor MI, Duarte CA, Los Angeles CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 4 - 25

Code: NCT04510051

Phase1, Recruiting
Active & Responsive

CREATE: Art for Children With Cancer

for
Hematopoietic and Lymphatic System Neoplasm,
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 8 - 13

Code: NCT06342453

Recruiting
Active & Responsive

Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors

for
Advanced Malignant Solid Neoplasm,
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT06320405

Phase1, Phase2, Recruiting