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Phase Ib Study of CD33 FPBMC in Patients With MRD+ AML or MDS

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes,
Location: Charlottesville VA
Sponsor: University of Virginia

Sex: All

Age: 18+

Code: NCT07270978

Phase1, Recruiting

Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC

for
Head and Neck Neoplasms, Carcinoma, Squamous Cell,
Location: Chicago IL
Sponsor: University of Chicago

Sex: All

Age: 18+

Code: NCT06912087

Phase1, Recruiting

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma

for
Advanced Dedifferentiated Liposarcoma, Advanced Leiomyosarcoma,
Location: Houston TX
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06498648

Phase1, Phase2, Recruiting

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

for
Breast Neoplasms, Neoplasm Metastasis
Location: Summit NJ, Philadelphia PA, Cherry Hill NJ, Sewell NJ,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT07174336

Phase3, Recruiting

A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 12+

Code: NCT04024761

Phase1, Recruiting

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A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors

for
SST2-positive Neuroendocrine Neoplasms, Neuroendocrine Tumors,
Location: New York NY, Philadelphia PA, Fairfax VA,
Sponsor: Crinetics Pharmaceuticals Inc.

Sex: All

Age: 18+

Code: NCT07129252

Phase1, Phase2, Recruiting

A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)

for
Neoplasm Malignant
Location: New Brunswick NJ, Montreal, Baltimore MD, Ottawa,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07209111

Phase2, Recruiting

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

for
Ovarian Neoplasms, Fallopian Tube Neoplasms,
Location: Scarborough ME, Providence RI, Farmington CT,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT07213804

Phase3, Recruiting

Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures

for
Brain Tumor
Location: Stanford CA
Sponsor: Stanford University

Sex: All

Age: 0 - 25

Code: NCT04085887

Phase1, Phase2, Recruiting

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

for
Metastatic Malignant Solid Neoplasm,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06911008

Phase1, Recruiting

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

for
Recurrent Solid Tumor, Recurrent Ewing Sarcoma,
Location: Montreal, Washington D.C. DC, Toronto, Atlanta GA,
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 1 - 30

Code: NCT04901702

Phase1, Phase2, Recruiting

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

for
Diffuse Midline Glioma, H3 K27-Altered,
Location: Boston MA, Valhalla NY, New York NY, Philadelphia PA,
Sponsor: Children's Oncology Group

Sex: All

Age: 1 - 21

Code: NCT04870944

Phase1, Phase2, Recruiting

Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas

for
Sarcoma, Childhood Osteosarcoma, Childhood Rhabdomyosarcoma,
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 21

Code: NCT07222735

Phase1, Recruiting

Two Step Haplo With Radiation Conditioning

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Philadephia PA
Sponsor: Thomas Jefferson University

Sex: All

Age: 18+

Code: NCT05031897

Phase2, Recruiting

Intent of Surgery for IPMN

for
Intraductal Papillary Mucinous Neoplasm
Location: Boston MA, New York NY, Baltimore MD, Durham NC,
Sponsor: NYU Langone Health

Sex: All

Age: 18+

Code: NCT07216521

Recruiting

Zanzalintinib Combined With Eribulin in Advanced Liposarcoma and Leiomyosarcoma

for
Advanced Leiomyosarcoma, Adipocytic Sarcoma,
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT06957431

Phase1, Recruiting

Sample Collection for Ongoing Research and Product Evaluation Study - Non-Hodgkin Lymphoma (SCORE-NHL)

for
Non-Hodgkin Lymphoma, T-Cell Lymphoma,
Location: Austin TX
Sponsor: Natera, Inc.

Sex: All

Age: 18+

Code: NCT07750886

Recruiting

Influencing Next-Generation Oncologic Outcomes Through Rapid Integration of Functional Precision Medicine (NOORI): A Feasibility Study of SmartMatch in Rare Gynecologic Cancers

for
Malignant Female Reproductive System Neoplasm,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: Female

Age: 18+

Code: NCT07731880

Recruiting

Patient Navigation and the Planning Advance Care Together Website to Improve Goals of Care Conversations in Hematopoietic Cell Transplant Survivors, IMPACT-HCT Trial

for
Hematopoietic and Lymphatic System Neoplasm
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT07052630

Recruiting

T Cell Membrane-Anchored Tumor-Targeted IL12 -Modified TIL Cell Therapy (attIL12-TIL) for Advanced/Metastatic Soft Tissue and Bone Sarcoma Patients.

for
Metastatic Soft-tissue Sarcoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 12+

Code: NCT06474676

Phase1, Recruiting