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Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

for
Hematopoietic and Lymphatic System Neoplasm,
Location: Scarborough ME, Providence RI, Hartford CT, Quebec,
Sponsor: Children's Oncology Group

Sex: Female

Age: 0 - 39

Code: NCT06513962

Phase3, Recruiting

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

for
Metastatic Malignant Neoplasm in the Liver,
Location: Westerly RI, Waterford CT, Guilford CT, Glastonbury CT,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT05040360

Phase2, Recruiting

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

for
Malignant Female Reproductive System Neoplasm,
Location: Brewer ME, Augusta ME, Scarborough ME, Providence RI,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06126276

Phase2, Recruiting

Trial of Nivolumab Following Partially Human Leukocyte Antigen (HLA) Mismatched BMT in Children & Adults With Sarcoma

for
Sarcoma, Solid Tumor, Adult, Solid Tumor, Childhood
Location: Valhalla NY, The Bronx NY, Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 1 - 40

Code: NCT03465592

Phase1, Phase2, Recruiting

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

for
Acute Lymphoblastic Leukemia in Remission,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18 - 70+

Code: NCT03670966

Phase1, Phase2, Recruiting

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Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma

for
Refractory Ewing Sarcoma, Relapsed Ewing Sarcoma, Ewing Sarcoma
Location: New York NY, Philadelphia PA, Baltimore MD,
Sponsor: Jazz Pharmaceuticals

Sex: All

Age: 2 - 30

Code: NCT05734066

Phase1, Phase2, Recruiting

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

for
Metastatic Malignant Neoplasm in the Brain,
Location: Jacksonville FL, La Crosse WI, Eau Claire WI,
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05222620

Phase2, Recruiting

Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma

for
Glioblastoma Multiforme
Location: Winnipeg
Sponsor: CancerCare Manitoba

Sex: All

Age: 18+

Code: NCT04530006

Recruiting
New

A Phase1 Clinical Trial Evaluating Locoregional Delivery Of Engineered NK Cells Containing IL13Ra And EGFvIII Chimeric Antigen Receptor (CAR), IL-21 Secretion And Deleted TGF-BetaR2 And NR3C1 In Recurrent Glioblastoma

for
Phase 1, NK Cell, IL13Ra, EGFRvIII,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT07579208

Phase1, Recruiting

A Phase I Study Investigating the Combination of the Menin Inhibitor Ziftomenib With Venetoclax and Gemtuzumab in Pediatric Patients With Acute Myeloid Leukemia

for
Acute Myeloid Leukemia
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 3 - 21

Code: NCT06448013

Phase1, Recruiting

Developing Restful Environments and Management Strategies for Pediatric Stem Cell Transplant Patients

for
Stem Cell Transplant Complications, Sleep Disturbance
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 9 - 17

Code: NCT06468618

Recruiting

Study of Pedi-cRIB: Mini-Hyper-CVD With Condensed Rituximab, Inotuzumab Ozogamicin and Blinatumomab (cRIB) for Relapsed Therapy for Pediatric With B-Cell Lineage Acute Lymphocytic Leukemia

for
Leukemia
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 1 - 25

Code: NCT05645718

Phase2, Recruiting

LET Optimized IMPT in Treating Pediatric Patients With Ependymoma

for
Anaplastic Ependymoma, Ependymoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 0 - 22

Code: NCT03750513

Phase1, Recruiting

A Phase I Study of Hyper-CVAD In Combination With Venetoclax In Pediatric Patients With Relapsed or Refractory Acute Leukemias That Are of the Lymphoid Lineage Including Bi-Phenotypic or Undifferentiated Leukemias

for
Refractory Acute Leukemia, Relapsed Acute Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 2 - 21

Code: NCT06466395

Phase1, Recruiting

MedSupport Intervention to Identify and Address Barriers to Pediatric Medication Adherence

for
Acute Lymphoblastic Leukemia
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 0+

Code: NCT06323044

Recruiting

Comprehensive Molecular and Clinical Evaluation of Pediatric and Adult MDS

for
Myelodysplastic Syndromes
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 0 - 70+

Code: NCT05350748

Recruiting

Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

for
Astrocytoma, IDH-Mutant, Grade 2,
Location: New Haven CT, Trumbull CT, Mineola NY, New York NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06860594

Phase1, Recruiting

Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms

for
Myelodysplastic Syndromes
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 12 - 70+

Code: NCT06303193

Phase1, Phase2, Recruiting

A Study of Emapalumab for Pediatric Aplastic Anemia

for
Aplastic Anemia, Cytopenia, Hypocellular Marrow
Location: New York NY, Philadelphia PA, Richmond VA,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 0 - 25

Code: NCT06430788

Phase2, Recruiting

Tumor Infiltrating Lymphocyte Therapy for Pediatric High Risk Solid Tumors

for
Lymphocytes
Location: St. Petersburg FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 1 - 21

Code: NCT06047977

Phase1, Recruiting