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Active & Responsive

Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461), in Combination With Another Anti-cancer Drug Cemiplimab (REGN2810), in Treating Refractory Microsatellite Stable Colorectal Cancer

for
Metastatic Colorectal Adenocarcinoma,
Location: Baltimore MD, Washington D.C. DC, Atlanta GA, Aurora CO
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT07147231

Phase 1, Phase 2, Recruiting
Active & Responsive

A Study for the PanCystPro Assay in the Management of Pancreatic Cystic Lesions

for
Pancreatic Cystic Lesions
Location: Boston MA, New Brunswick NJ, Indianapolis IN
Sponsor: Amplified Sciences Inc

Sex: All

Age: 18+

Code: NCT06894329

Recruiting
Active & Responsive

A Study of ELA026 in Participants With Relapsed/Refractory (R/R) T/NK Cell Malignancies (TCMs)

for
T Cell Malignancies
Location: New Haven CT, New York NY, Cleveland OH, Atlanta GA,
Sponsor: Electra Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT07465835

Phase 1, Recruiting
Active & Responsive

A Cancer Vaccine (STEMVAC) in Combination With Chemotherapy for the Treatment of PD-L1 Negative Metastatic Triple-Negative Breast Cancer

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 18+

Code: NCT07078604

Phase 2, Recruiting
Active & Responsive

PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease

for
Breast Cancer, Residual Disease,
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT07069595

Phase 2, Recruiting

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Active & Responsive

Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors

for
Endometrial Cancer, Ovarian Cancer, Ovarian Cancer Metastatic,
Location: Hackensack NJ, Fairfax VA, Buffalo NY, Cleveland OH,
Sponsor: Whitehawk Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07444814

Phase 1, Recruiting
Active & Responsive

KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortumab Vedotin and Pembrolizumab in People With Urothelial Cancer (MK-3475-04D/KEYMAKER-U04)

for
Bladder Cancer
Location: New York NY, Cleveland OH, Chicago IL,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07232602

Phase 1, Phase 2, Recruiting
Active & Responsive

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

for
Glioblastoma (GBM), Newly Diagnosed Glioblastoma, GBM,
Location: Boston MA, New Haven CT, Lake Success NY, The Bronx NY,
Sponsor: Black Diamond Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07326566

Phase 2, Recruiting
Active & Responsive

Clinical Validation of Early Detection Blood Test for Universal Large-scale Breast Cancer Screening

for
Breast Cancer, Liquid Biopsy, Early Detection
Location: Phoenix AZ
Sponsor: Syantra Inc.

Sex: Female

Age: 30 - 70+

Code: NCT07219277

Recruiting
Active & Responsive

Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

for
Rectal Adenocarcinoma, Rectal Cancer
Location: Aurora CO
Sponsor: University of Colorado, Denver

Sex: All

Age: 18 - 70+

Code: NCT07292298

Phase 2, Recruiting
Active & Responsive

Efficacy and Safety Evaluation of VS-101 in Combination With Chemoradiotherapy in Patients With Head and Neck Cancer

for
Head and Neck Cancer Squamous Cell Carcinoma
Location: New Haven CT, Manhattan NY
Sponsor: VSPharmTech Co.,Ltd.

Sex: All

Age: 18+

Code: NCT06959082

Phase 2, Recruiting
Active & Responsive

Risk-adapted, Proteomic-guided Systemic Therapy for Previously Untreated Advanced Non-small Cell Lung Cancer

for
Non-small Cell Lung Cancer Stage IIIC,
Location: Truckee CA, Chico CA, Marysville CA, Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT07250477

Phase 2, Recruiting
Active & Responsive

A Phase 1 Study to Evaluate Safety and Efficacy of XER-001 (Amifostine for Nasoduodenal Delivery) in Combination With Sterotactic Body Radiotherapy for Treatment in Patients With Locally Advanced Pancreatic Cancer.

for
Locally Advanced Pancreatic Adenocarcinoma,
Location: Detroit MI, Houston TX, Santa Fe NM, Irvine CA,
Sponsor: Xerient Pharma

Sex: All

Age: 18+

Code: NCT07157033

Phase 1, Phase 2, Recruiting
Active & Responsive

Evaluation of RAS Inhibitor Treatment in Participants With Advanced or Metastatic Solid Tumors Harboring RAS Mutations

for
Solid Tumors (Phase 1), RAS Mutation
Location: Orlando FL, Houston TX
Sponsor: Adlai Nortye Biopharma Co., Ltd.

Sex: All

Age: 18+

Code: NCT07252479

Phase 1, Recruiting
Active & Responsive

A Phase 1b/2 Study of IM-101 in Adult Participants With Generalized Myasthenia Gravis and Ocular Myasthenia Gravis

for
Myasthenia Gravis
Location: Boca Raton FL, Altamonte Springs FL, Naples FL,
Sponsor: ImmunAbs Inc.

Sex: All

Age: 18 - 70+

Code: NCT07250750

Phase 1, Phase 2, Recruiting
Active & Responsive

Using Plasma Human Papillomavirus (HPV)-Related Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) to Follow Response of Cervical Cancer to Surgery, Radiation, and Chemotherapy

for
Cervical Cancer, Human Papilloma Virus (HPV)
Location: Gainesville FL
Sponsor: University of Florida

Sex: Female

Age: 18 - 70+

Code: NCT07214584

Recruiting
Active & Responsive

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

for
Head and Neck Cancer, Squamous Cell Carcinoma,
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18+

Code: NCT07209189

Phase 2, Recruiting
Active & Responsive

A Study of Emavusertib + An Approved Bruton Tyrosine Kinase Inhibitor (BTKi) in Participants With Chronic Lymphocytic Leukemia (CLL) and Other B-cell Malignancies

for
Chronic Lymphocytic Leukemia, B-cell Malignancies
Location: Florham Park NJ, Miami Beach FL, Pittsburgh PA,
Sponsor: Curis, Inc.

Sex: All

Age: 18+

Code: NCT07271667

Phase 2, Recruiting
Active & Responsive

A Study of the Combination of Ivosidenib, Azacitidine, and Venetoclax Followed by Ivosidenib Alone in People With Acute Myeloid Leukemia

for
Acute Myeloid Leukemia
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 60+

Code: NCT07392242

Phase 2, Recruiting
Active & Responsive

Multimodal Telerehabilitation in Patients Undergoing CAR-T Cell Immunotherapy

for
Lymphoma, Myeloma, Cytokine Release Syndrome,
Location: Salt Lake City UT
Sponsor: University of Utah

Sex: All

Age: 21+

Code: NCT07390071

Recruiting