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Active & Responsive

Leflunomide in Patients With PTEN-Altered Advanced Solid Malignancies and HER2 Negative Breast Cancer

for
PTEN-Altered Advanced Solid Tumors and HER2 Negative Breast Cancer,
Location: New York NY
Sponsor: Deborah Doroshow

Sex: All

Age: 18+

Code: NCT04997993

Phase 1, Recruiting
Active & Responsive

Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

for
Pleuropulmonary Blastoma
Location: Halifax, Boston MA, Quebec, Sherbrooke,
Sponsor: Children's Oncology Group

Sex: All

Age: 0 - 21

Code: NCT06647953

Phase 3, Recruiting
Active & Responsive

Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and Efficacy

for
Acute Myeloid Leukemia
Location: Hershey PA, Cincinnati OH, Madison WI, Memphis TN,
Sponsor: Norman J. Lacayo

Sex: All

Age: 0 - 21

Code: NCT05101551

Phase 1, Recruiting
Active & Responsive

Futibatinib in Combination With Durvalumab Prior to Cystectomy for the Treatment of Muscle-Invasive Bladder Cancer Patients Who Are Ineligible for Cisplatin-based Therapy

for
Bladder Urothelial Carcinoma, Muscle Invasive Bladder Carcinoma,
Location: Cleveland OH, Columbus OH
Sponsor: Yuanquan Yang

Sex: All

Age: 18+

Code: NCT06263153

Phase 2, Recruiting
Active & Responsive

Y-90, Capecitabine, and Atezolizumab for Oligometastatic CRC

for
Colorectal Carcinoma Metastatic in the Liver
Location: Providence RI
Sponsor: Brown University

Sex: All

Age: 18+

Code: NCT06555133

Phase 2, Recruiting

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Active & Responsive

RAGE Inhibition to Decrease Cardiotoxicity in Women With Early Breast Cancer

for
Cancer Related Cognitive Decline, Non-metastatic Breast Cancer
Location: Hackensack NJ, Washington D.C. DC
Sponsor: Georgetown University

Sex: Female

Age: 18+

Code: NCT05256745

Phase 1, Phase 2, Recruiting
Active & Responsive

Safety and Preliminary Efficacy of MT-601 in Patients With Relapsed/Refractory Lymphoma

for
Non-Hodgkin Lymphoma, Adult, Non-Hodgkin Lymphoma, Refractory,
Location: New York NY, Madison WI, Kansas City KS, Austin TX,
Sponsor: Marker Therapeutics, Inc.

Sex: All

Age: 18 - 70+

Code: NCT05798897

Phase 1, Recruiting
Active & Responsive

Safety and Efficacy of 3 Dose Levels of NMD670 in Adult Patients With Myasthenia Gravis

for
Myasthenia Gravis, Myasthenia Gravis, MuSK
Location: Chapel Hill NC, Boca Raton FL, Tampa FL, Augusta GA,
Sponsor: NMD Pharma A/S

Sex: All

Age: 18+

Code: NCT06414954

Phase 2, Recruiting
Active & Responsive

Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer

for
Breast Cancer, Breast Neoplasm, Breast Tumor,
Location: New York NY, Hampton VA, Baltimore MD, Fairfax VA,
Sponsor: Proton Collaborative Group

Sex: Female

Age: 50+

Code: NCT01766297

Phase 2, Recruiting
Active & Responsive

Genomically Guided Radiation Therapy in the Management of Triple Negative Breast Cancer

for
Triple Negative Breast Cancer
Location: Tampa FL, Clearwater FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT05528133

Phase 2, Recruiting
Active & Responsive

KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

for
Carcinoma, Non-Small-Cell Lung
Location: Lebanon NH, Philadelphia PA, Columbus OH, Houston TX,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT04165798

Recruiting
Active & Responsive

Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays

for
Colorectal Cancer
Location: York PA, Bethesda MD, Goldsboro NC, Canton OH,
Sponsor: Tempus AI

Sex: All

Age: 18+

Code: NCT05234177

Recruiting
Active & Responsive

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

for
Glioblastoma
Location: Boston MA, New Haven CT, New York NY, Montreal,
Sponsor: Global Coalition for Adaptive Research

Sex: All

Age: 18+

Code: NCT03970447

Phase 2, Phase 3, Recruiting
Active & Responsive

Maintenance Niraparib Plus Ipilimumab in Patients With Metastatic Pancreatic Adenocarcinoma Whose Disease Has Not Progressed on Platinum-Based Chemotherapy

for
Pancreatic Adenocarcinoma Metastatic
Location: Boston MA, Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 18+

Code: NCT06747845

Phase 2, Recruiting
Active & Responsive

Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study

for
Breast Cancer, Disability Physical, Heart Failure,
Location: Edmonton
Sponsor: University of Alberta

Sex: Female

Age: 60+

Code: NCT06595147

Recruiting
Active & Responsive

Safety Study to Evaluate the Occurrence of EFAD in Pediatric Patients With PNAC Who Require More Than Eight Weeks of Omegaven Treatment

for
Parenteral Nutrition Associated Liver Disease (PNALD),
Location: Boston MA, Cincinnati OH, Nashville TN, Chicago IL,
Sponsor: Fresenius Kabi

Sex: All

Age: 0 - 17

Code: NCT06274788

Recruiting
Active & Responsive

Protein Needs Study

for
Colorectal Cancer, Breast Cancer
Location: Edmonton
Sponsor: University of Alberta

Sex: All

Age: 45 - 70+

Code: NCT04144907

Recruiting
Active & Responsive

Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma

for
Melanoma, Unresectable Melanoma
Location: Boston MA, New York NY, Los Angeles CA
Sponsor: NYU Langone Health

Sex: All

Age: 18 - 70+

Code: NCT05428007

Phase 2, Recruiting
Active & Responsive

Intensity Modulated Total Marrow Irradiation in Fully Human Leukocyte Antigen (HLA)-Matched and Partially-HLA Mismatched Allogeneic Transplantation Patients With High-Risk Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), and Myelodysplastic Syndrome (MDS)

for
Acute Myeloid Leukemia, Relapsed, Adult,
Location: Chicago IL
Sponsor: University of Illinois at Chicago

Sex: All

Age: 18 - 65

Code: NCT06802315

Phase 2, Recruiting
Active & Responsive

A Pancreatic Cancer Screening Study in Hereditary High Risk Individuals

for
Pancreatic Neoplasms
Location: Norwalk CT
Sponsor: Nuvance Health

Sex: All

Age: 50 - 70+

Code: NCT03250078

Recruiting