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Larotrectinib for the Treatment of NTRK Amplification Positive, Locally Advanced or Metastatic Solid Tumors

for
Locally Advanced Malignant Solid Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 16+

Code: NCT04879121

Phase 2, Recruiting

SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells

for
Pancreatic Adenocarcinoma Metastatic, BRCA1 Mutation,
Location: New York NY
Sponsor: General Oncology, Inc.

Sex: All

Age: 18+

Code: NCT04150042

Phase 1, Recruiting

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

for
Anatomic Stage III Breast Cancer AJCC v8,
Location: Boston MA, St Louis MO
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT07137416

Phase 1, Recruiting

PEN-866 in Patients With Advanced Solid Malignancies

for
Carcinoma, Endometrial Adenocarcinoma, Neoplasms,
Location: Philadelphia PA, Bethesda MD, Fairfax VA,
Sponsor: Tarveda Therapeutics

Sex: All

Age: 18+

Code: NCT03221400

Phase 1, Phase 2, Recruiting
Featured

Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)

for
Chronic Lymphocytic Leukemia (CLL)
Location: Boston MA, Hackensack NJ, Philadelphia PA,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT04895436

Phase 2, Recruiting

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Featured

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

for
Non-Small Cell Lung Cancer,
Location: Montreal, Fairfax VA, Durham NC, Toronto,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT05005403

Phase 1, Recruiting

Induction Chemotherapy Response-Guided Radiation for EBV-Associated Nasopharyngeal Carcinoma

for
Nasopharyngeal Carcinoma,
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT06682442

Recruiting

Targeted Immunotherapy After Myeloablative TBI-Based Conditioning & AlloHCT in CAYA With High Risk T-Cell ALL & Lymphoma

for
T-cell Acute Lymphoblastic Leukemia,
Location: Boston MA, Vallhala NY, Philadelphia PA, Gainsville FL,
Sponsor: New York Medical College

Sex: All

Age: 0 - 39

Code: NCT04972942

Phase 1, Recruiting

Ultra Hypofractionnated Radiotherapy With HDR Brachytherapy Boost.

for
Prostate Cancer, Radiotherapy Side Effect, Hypofractionation,
Location: Quebec
Sponsor: CHU de Quebec-Universite Laval

Sex: Male

Age: 18 - 70+

Code: NCT05786742

Recruiting

Bright Ideas - CIN Feasibility Study

for
Acute Lymphoblastic Leukemia (ALL)
Location: New Brunswick NJ, Falls Church VA, Toronto,
Sponsor: The Hospital for Sick Children

Sex: All

Age: 4 - 18

Code: NCT04929899

Recruiting

Low PSMA SUV Boost (LPS-Boost): Intensified 177Lu-PSMA-617 Treatment for Patients With Metastatic Castrate-Resistant Prostate Cancer With Low PSMA Expressing Disease

for
Metastatic Castration-Resistant Prostate Carcinoma,
Location: Seattle WA, San Francisco CA
Sponsor: University of Washington

Sex: Male

Age: 18+

Code: NCT06526299

Phase 2, Recruiting

Umbilical Cord Blood Transplantation From Unrelated Donors

for
Acute Leukemia, Immune Deficiency Disorder,
Location: Rochester NY
Sponsor: University of Rochester

Sex: All

Age: 0 - 70+

Code: NCT03016806

Recruiting

CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

for
HER2-negative Breast Cancer, Metastatic Breast Cancer
Location: Baltimore MD, Chapel Hill NC, Chicago IL, Dallas TX,
Sponsor: University of Texas Southwestern Medical Center

Sex: All

Age: 18 - 70+

Code: NCT05029999

Phase 1, Recruiting

Toxicity Genetic Determinants and Response to Azacitidine and Venetoclax in AML

for
Leukemia, Myeloid, Acute
Location: Winston-Salem NC, Charlotte NC
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 18+

Code: NCT06580106

Recruiting

Vaccine Responses in Patients With B Cell Malignancies

for
Lymphoma
Location: Bethesda MD
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All

Age: 18 - 70+

Code: NCT05170399

Recruiting

Comparison of Between ThinSeed™ and OncoSeed™ for Permanent Prostate Brachytherapy

for
Prostate Cancer
Location: Westmont IL
Sponsor: Prostate Cancer Foundation of Chicago

Sex: Male

Age: 40+

Code: NCT01379742

Recruiting

Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes,
Location: Rochester NY
Sponsor: Omar Aljitawi

Sex: All

Age: 18 - 70+

Code: NCT03964506

Early Phase 1, Recruiting

A Study to Investigate the Safety and Efficacy of SAR446523 Injected Subcutaneously in Adult Participants With Relapsed/Refractory Myeloma

for
Plasma Cell Myeloma Refractory
Location: Sherbrooke, Hackensack NJ, Montreal, Philadelphia PA,
Sponsor: Sanofi

Sex: All

Age: 18+

Code: NCT06630806

Phase 1, Recruiting

TSC Biosample Repository and Natural History Database

for
Tuberous Sclerosis, Lymphangioleiomyomatosis
Location: Boston MA, New York NY, Montreal, Philadelphia PA,
Sponsor: National Tuberous Sclerosis Association

Sex: All

Age: 0+

Code: NCT05676099

Recruiting

A Study of sEphB4-HSA in Kaposi Sarcoma

for
Kaposi Sarcoma
Location: Sarasota FL, Dallas TX, Beverly Hills CA
Sponsor: Vasgene Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT03993106

Phase 2, Recruiting