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Active & Responsive

A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

for
Drug Resistant Epilepsy, Epilepsy, Seizures, Focal, Seizure,
Location: Boston MA, Charlottesville VA, Palo Alto CA
Sponsor: NaviFUS Corporation

Sex: All

Age: 18+

Code: NCT06388707

Phase1, Phase2, Recruiting
Active & Responsive

A Phase 1/2 Study of BHV-1510 (Previously PBI-410) in Advanced Solid Tumors

for
Solid Tumor
Location: New York NY, Philadelphia PA, Washington D.C. DC,
Sponsor: Biohaven Therapeutics Ltd.

Sex: All

Age: 18+

Code: NCT06384807

Phase1, Phase2, Recruiting
Active & Responsive

Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial

for
Advanced Esophageal Adenocarcinoma,
Location: Westerly RI, Waterford CT, Guilford CT, Glastonbury CT,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06203600

Phase2, Phase3, Recruiting
Active & Responsive

Biofeedback Training for Hemianopia

for
Hemianopia, Brain Injuries
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18 - 70+

Code: NCT06995313

Recruiting
Active & Responsive

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

for
Clinical Stage III Cutaneous Melanoma AJCC v8,
Location: Springfield MA, Saint Johnsbury VT, Lebanon NH,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05136196

Phase2, Recruiting

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Active & Responsive

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

for
Recurrent Head and Neck Squamous Cell Carcinoma,
Location: Boston MA, Waterford CT, New Haven CT, Stony Brook NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT04671667

Phase2, Recruiting
Active & Responsive

A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

for
Crohn's Disease
Location: Kentville, Boston MA, Providence RI, Levis,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 16 - 70+

Code: NCT06430801

Phase3, Recruiting
Active & Responsive

Restoration of Hand Function in Cervical SCI

for
Spinal Cord Injury Cervical
Location: Cleveland OH
Sponsor: MetroHealth Medical Center

Sex: All

Age: 18+

Code: NCT06611748

Recruiting
Active & Responsive

KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia Gravis

for
Myasthenia Gravis, Generalized Myasthenia Gravis
Location: Philadelphia PA, Miami FL, Indianapolis IN, Columbia MO,
Sponsor: Kyverna Therapeutics

Sex: All

Age: 18 - 70+

Code: NCT06193889

Phase2, Phase3, Recruiting
Active & Responsive

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

for
Metastatic Head and Neck Squamous Cell Carcinoma,
Location: Boston MA, Saint Johnsbury VT, Lebanon NH, Commack NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06589804

Phase3, Recruiting
Active & Responsive

Pain Outcomes Associated With Exogenous Hormone Therapy in Adults

for
Pain, Gender Minority Individuals
Location: Kansas City KS
Sponsor: University of Kansas Medical Center

Sex: All

Age: 18 - 50

Code: NCT06939257

Recruiting
Active & Responsive

PCS in Severe Treatment Resistant Depression

for
Treatment Resistant Depression
Location: Minneapolis MN
Sponsor: University of Minnesota

Sex: All

Age: 22 - 70

Code: NCT04124341

Recruiting
Active & Responsive

Cardiometabolic Risk Effects of Short-term Cessation of Neurostimulation Therapy

for
Obstructive Sleep Apnea, Obstructive Sleep Apnea of Adult
Location: New York NY
Sponsor: Columbia University

Sex: All

Age: 18+

Code: NCT06720545

Recruiting
Active & Responsive

Positive Processes and Transition to Health - Single-Session (PATH-SS)

for
PTSD, Depression
Location: Cleveland OH
Sponsor: Case Western Reserve University

Sex: All

Age: 18 - 65

Code: NCT06900712

Recruiting
Active & Responsive

Characterizing Synaptic Density in Treatment Resistant Depression

for
Treatment Resistant Depression,
Location: Toronto
Sponsor: Unity Health Toronto

Sex: All

Age: 25 - 65

Code: NCT03537794

Recruiting
Active & Responsive

Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use

for
Nicotine Dependence
Location: Los Angeles CA
Sponsor: University of Southern California

Sex: All

Age: 21 - 55

Code: NCT07698470

Recruiting
Active & Responsive

Listening Effort in Cochlear Implant Users

for
Auditory Perception; Abnormal, Hearing Loss, Sensorineural,
Location: Minneapolis MN
Sponsor: University of Minnesota

Sex: All

Age: 18 - 70+

Code: NCT06516575

Recruiting
Active & Responsive

PRT for Chronic Low Back Pain

for
Chronic Low Back Pain (CLBP), Nociplastic Pain
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18 - 65

Code: NCT07696741

Recruiting
Active & Responsive

Speech Motor Learning and Retention (Aim 3)

for
Speech
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 18 - 40

Code: NCT06492252

Recruiting
Active & Responsive

Identification and Validation of Epigenetic Biomarkers of PMDD

for
PMDD, Premenstrual Dysphoric Disorder (PMDD),
Location: Baltimore MD
Sponsor: Johns Hopkins University

Sex: Female

Age: 18 - 50

Code: NCT06771583

Recruiting