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Active & Responsive

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

for
Sickle Cell Disease
Location: The Bronx NY, Philadelphia PA, Easton PA, Baltimore MD,
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 12 - 70+

Code: NCT06439082

Phase3, Recruiting
Active & Responsive

Early Neurovascular Adaptations in Aging Women

for
Women, Sympathetic Nervous System, Aging, Blood Flow
Location: Columbia MO
Sponsor: University of Missouri-Columbia

Sex: Female

Age: 18 - 70

Code: NCT06520982

Early_phase1, Recruiting
Active & Responsive

Targeting Transdiagnostic Self-regulatory Factors and Eating Disorder Pathology Among Adults With BInge-spectrum Eating disOrders: A mHEALTH Interoceptive Exposure Intervention (the Bio-HEALTH Study)

for
Eating Disorders
Location: Minneapolis MN
Sponsor: University of Minnesota

Sex: All

Age: 18 - 64

Code: NCT06631729

Recruiting
Active & Responsive

Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy

for
Diabetic Peripheral Neuropathic Pain
Location: Boston MA, East Greenwich RI, Waterbury CT, Brooklyn NY,
Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All

Age: 18 - 70+

Code: NCT07231419

Phase3, Recruiting
Active & Responsive

Assess the Effects of Replacing Foods High in Refined Carbohydrates With Avocado on Biomarkers of Inflammation.

for
Overweight (BMI > 25), Obesity (BMI>30), Hs-CRP
Location: Chicago IL
Sponsor: Midwest Center for Metabolic and Cardiovascular Research

Sex: All

Age: 21 - 70+

Code: NCT07566325

Recruiting

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Active & Responsive

Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression

for
Treatment-Resistant Depression
Location: Toronto
Sponsor: Centre for Addiction and Mental Health

Sex: All

Age: 18 - 70

Code: NCT07211438

Phase2, Recruiting
Active & Responsive

Virtual Poetry Workshops to Enhance Patient Well Being and Reduce Anxiety

for
Dyspepsia, Gastroparesis, Anxiety, Depression
Location: Columbus OH
Sponsor: Ohio State University

Sex: All

Age: 18+

Code: NCT07717541

Recruiting
Active & Responsive

ILKN421H Plus Pembrolizumab in Advanced Non-Small Cell Lung Cancer

for
Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC),
Location: Fort Worth TX, Los Angeles CA
Sponsor: iLeukon Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07452224

Phase2, Recruiting
Active & Responsive

Effects of Hard Gum Chewing on Facial Soft Tissue Morphology

for
Face
Location: Farmington CT
Sponsor: UConn Health

Sex: All

Age: 20 - 40

Code: NCT07726511

Recruiting
Active & Responsive

MDMA Therapy in Veterans With PTSD

for
Post Traumatic Stress Disorder
Location: Rockville MD
Sponsor: Sunstone Medical

Sex: All

Age: 18+

Code: NCT07569159

Phase2, Recruiting
Active & Responsive

A Study of BBT001 in Healthy Volunteers (HVs) and in Adult Patients With Atopic Dermatitis (AD)

for
Atopic Dermatitis
Location: The Bronx NY, New York NY, Irvine CA
Sponsor: Bambusa Therapeutics

Sex: All

Age: 18 - 70+

Code: NCT06808477

Phase1, Recruiting
Active & Responsive

Imaging Metabolic and Perfusion Changes in Acupuncture Therapy for Myofascial Pain Syndrome

for
Myofascial Pain Syndrome (MPS), Chronic Low-back Pain (cLBP)
Location: Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT07494162

Recruiting
Active & Responsive

Cervicothoracic Sympathetic Block Evaluation for Post COVID Condition

for
Autonomic Dysfunction
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT07468604

Recruiting
Active & Responsive

kTMP-Enhanced Motor Rehabilitation for Chronic Stroke Recovery (KULMINATE) Pilot

for
Stroke, Chronic Stroke Patients,
Location: San Francisco CA
Sponsor: Magnetic Tides

Sex: All

Age: 18 - 70+

Code: NCT07631078

Recruiting
Active & Responsive

Stratified Pharmacological Approaches for Regulating Circuit-Level Effects

for
Depression - Major Depressive Disorder
Location: Palo Alto CA
Sponsor: Stanford University

Sex: All

Age: 18 - 65

Code: NCT07022405

Phase2, Recruiting
Active & Responsive

Evaluating Noninvasive Brain Stimulation for TMD Pain: A Feasibility Study

for
Temporomandibular Disorder
Location: Minneapolis MN
Sponsor: University of Minnesota

Sex: All

Age: 18 - 65

Code: NCT07517172

Recruiting
Active & Responsive

Validation of Effectiveness on NaturalCycles Users

for
Contraception
Location: New York NY
Sponsor: Natural Cycles

Sex: Female

Age: 18 - 35

Code: NCT07566793

Recruiting
Active & Responsive

45th Multicenter Airway Research Collaboration

for
Asthma Acute, Asthma Exacerbation, Asthma, Asthma Control Level
Location: Cleveland OH
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18 - 54

Code: NCT07166939

Recruiting
Active & Responsive

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

for
Pulmonary Arterial Hypertension
Location: Boston MA, Hamilton, Atlanta GA, Scottsdale AZ,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07218029

Phase3, Recruiting
Active & Responsive

HELIOS Advanced: Human Oocyte Illumination to Enhance Development

for
IVF Outcomes
Location: New York NY
Sponsor: Columbia University

Sex: Female

Age: 18 - 48

Code: NCT07425080

Recruiting