Browse 1,747 esophageal cancer clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.
There are two main types of esophageal cancer, and in the United States the more common one is now adenocarcinoma, linked to long term acid reflux and a condition called Barrett's esophagus. Because the esophagus stretches easily, symptoms such as trouble swallowing often appear only after the cancer has grown. Outcomes improve most when cancer is found early and treated with combinations, and trials are testing immunotherapy, targeted drugs, and better ways to spot cancer in people with Barrett's esophagus before it develops.
Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
for
Solid Tumor Malignancies, Colorectal Carcinoma,
Location: Philadelphia PA, Fairfax VA, Orlando FL,
Sponsor: Tasca Therapeutics
Sex: All
Age: 18+
Code: NCT07030257
Phase 1, Phase 2, Recruiting
Active & Responsive
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
for
Solid Tumor, Non-Small-Cell Lung Cancer,
Location: New York NY, Hackensack NJ, Fairfax VA, Buffalo NY,
Sponsor: Astellas Pharma Inc
Sex: All
Age: 18+
Code: NCT07094204
Phase 1, Recruiting
Active & Responsive
A Study of ERAS-4001 in Patients With Advanced or Metastatic Solid Tumors.
for
Metastatic Solid Tumors
Location: Nashville TN, Houston TX, Irving TX, San Antonio TX,
Sponsor: Erasca, Inc.
Sex: All
Age: 18 - 70+
Code: NCT07021898
Phase 1, Recruiting
Active & Responsive
A Study to Investigate the Safety and Efficacy of KQB168 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies
for
Solid Tumor Malignancies
Location: New Haven CT, Fairfax VA, Jacksonville FL, Sarasota FL,
Sponsor: Kumquat Biosciences Inc.
Sex: All
Age: 18+
Code: NCT06994806
Phase 1, Recruiting
Active & Responsive
Mayo Clinic Radiotherapy Patient Outcomes Registry and Biobanking Study
for
Solid Tumors, Hematologic Malignancies
Location: Rochester MN
Sponsor: Mayo Clinic
Sex: All
Age: 0+
Code: NCT02457962
Recruiting
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Active & Responsive
The Cancer Stage Shifting Initiative: Registry and Biorepository to Research and Address Health Disparities in Cancer Care
for
Cancer, Cancer Comorbidities
Location: Flint MI, Houston TX
Sponsor: National Minority Quality Forum
Sex: All
Age: 35+
Code: NCT07461493
Recruiting
Active & Responsive
Efficacy of Point Of Service Testing in MBC
for
Metastatic Cancer, Breast Cancer
Location: Kansas City KS
Sponsor: University of Kansas Medical Center
Sex: All
Age: 18+
Code: NCT03983577
Recruiting
Active & Responsive
CREATE: Art for Children With Cancer
for
Hematopoietic and Lymphatic System Neoplasm,
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute
Sex: All
Age: 8 - 13
Code: NCT06342453
Recruiting
Active & Responsive
Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmocodynamics and Preliminary Antitumor Activity of AT-1965 in Patients With Advanced, Refractory or Recurrent Solid Tumors
for
Solid Tumor
Location: Dallas TX, Scottsdale AZ, Portland OR, El Segundo CA,
Sponsor: Alyssum Therapeutics
Sex: All
Age: 18+
Code: NCT06234098
Phase 1, Phase 2, Recruiting
Active & Responsive
A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)
for
Advanced Solid Tumors
Location: Moncton, Hackensack NJ, Fairfax VA, Kingston, Toronto,
Sponsor: Merck Sharp & Dohme LLC
Sex: All
Age: 18+
Code: NCT05067283
Phase 1, Recruiting
Active & Responsive
Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors
for
Advanced Solid Tumors
Location: Boston MA, New York NY, Hackensack NJ,
Sponsor: ModernaTX, Inc.
Sex: All
Age: 12+
Code: NCT05533697
Phase 1, Phase 2, Recruiting
Active & Responsive
Sacituzumab Govitecan in Combination With Capecitabine for Advanced Gastrointestinal Cancers After Progression on Standard Therapy
for
Gastrointestinal Cancer
Location: Detroit MI
Sponsor: Henry Ford Health System
Sex: All
Age: 18+
Code: NCT06065371
Phase 1, Recruiting
Active & Responsive
Activating Cancer Communities Through an Exercise Strategy for Survivors
for
Cancer
Location: Halifax
Sponsor: Nova Scotia Health Authority
Sex: All
Age: 18+
Code: NCT03599843
Recruiting
Active & Responsive
OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages
for
Eosinophilic Gastrointestinal Disorders (EGIDs),
Location: New York NY, Philadelphia PA, Bethesda MD,
Sponsor: Children's Hospital Medical Center, Cincinnati
Sex: All
Age: 3+
Code: NCT02523118
Recruiting
Active & Responsive
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Location: Boston MA, New Haven CT, New York NY, Fairfax VA,
Sponsor: Institut de Recherches Internationales Servier
Sex: All
Age: 18+
Code: NCT05786924
Phase 1, Phase 2, Recruiting
Active & Responsive
A Study of ERAS-0015 in Patients With Advanced or Metastatic Solid Tumors
for
Metastatic Solid Tumors
Location: Boston MA, New York NY, Fairfax VA, Toronto, Tampa FL,
Sponsor: Erasca, Inc.
Sex: All
Age: 18 - 70+
Code: NCT06983743
Phase 1, Recruiting
Active & Responsive
Biomarkers to Predict Cancer Therapy-related Cardiotoxicity
for
Hematopoietic and Lymphatic System Neoplasm,
Location: Jacksonville FL, Tampa FL, Scottsdale AZ
Sponsor: Mayo Clinic
Sex: All
Age: 18+
Code: NCT06353191
Recruiting
Active & Responsive
Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms
for
Barrett Esophagus, Gastroesophageal Reflux,
Location: Baltimore MD, Chapel Hill NC, Cleveland OH, Aurora CO
Sponsor: Case Comprehensive Cancer Center
Sex: All
Age: 50+
Code: NCT06687603
Recruiting
Active & Responsive
Oxaliplatin and Liposomal Irinotecan (Plus Trastuzumab for HER2-positive Disease) in Advanced Esophageal and Gastric Adenocarcinoma
for
Esophageal Adenocarcinoma, Gastric Adenocarcinoma
Location: Madison WI
Sponsor: University of Wisconsin, Madison
Sex: All
Age: 18+
Code: NCT04150640
Phase 2, Recruiting
Active & Responsive
A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)
for
Esophageal Squamous Cell Carcinoma
Location: East Syracuse NY, Pittsburgh PA, Tucson AZ,