Browse 1,747 esophageal cancer clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.
There are two main types of esophageal cancer, and in the United States the more common one is now adenocarcinoma, linked to long term acid reflux and a condition called Barrett's esophagus. Because the esophagus stretches easily, symptoms such as trouble swallowing often appear only after the cancer has grown. Outcomes improve most when cancer is found early and treated with combinations, and trials are testing immunotherapy, targeted drugs, and better ways to spot cancer in people with Barrett's esophagus before it develops.
A Study to Assess the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic, Immunogenicity and Antitumour Activity of IPN60300 in Adults With Locally Advanced or Metastatic Solid Tumours
Location: New Haven CT, Philadelphia PA, Fairfax VA,
Sponsor: Ipsen
Sex: All
Age: 18+
Code: NCT07213817
Phase 1, Phase 2, Recruiting
Active & Responsive
KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
for
Malignant Neoplasm
Location: Clermont FL, Fargo ND, Sioux Falls SD
Sponsor: Merck Sharp & Dohme LLC
Sex: All
Age: 18+
Code: NCT07252739
Phase 2, Recruiting
Active & Responsive
Head and Neck Cancer Study Project in the Geriatric Population
for
Head and Neck Neoplasms
Location: Providence RI
Sponsor: Brown University
Sex: All
Age: 65+
Code: NCT06998069
Phase 3, Recruiting
Active & Responsive
A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Anti-tumour Activity of IPN01203 in Adults With Locally Advanced or Metastatic Solid Tumours Exposed to Immune Checkpoint Inhibitor Therapies
for
Advanced Solid Tumor, Metastatic Solid Tumor
Location: Toronto, Grand Rapids MI, Nashville TN, Houston TX,
Sponsor: Ipsen
Sex: All
Age: 18+
Code: NCT07213830
Phase 1, Phase 2, Recruiting
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Active & Responsive
The Sarah Nanotechnology System for Treatment of Advanced Metastatic Solid Tumors Using Hyperthermia.
for
Metastatic Solid Tumors, Stage 4 Cancer
Location: Rochester MN
Sponsor: New Phase Ltd.
Sex: All
Age: 18+
Code: NCT07224464
Recruiting
Active & Responsive
A Study of DS3610a in Participants With Advanced Solid Tumor
for
Solid Tumors, Metastatic Solid Tumors
Location: Milwaukee WI
Sponsor: Daiichi Sankyo
Sex: All
Age: 18+
Code: NCT07159126
Phase 1, Recruiting
Active & Responsive
A Pilot Study of Ultra-High Dose Rate (ConformalFLASH®), for Reirradiation of Carcinoma of the Head and Neck
for
Head and Neck Cancer
Location: Philadelphia PA
Sponsor: IBA Proton Therapy, Inc.
Sex: All
Age: 18+
Code: NCT07644585
Recruiting
Active & Responsive
Development of a Noninvasive Metric to Measure Small Bowel Sensation - The Small Intestine Stress Test
for
Disorders of Gut Brain Interaction
Location: Rochester MN
Sponsor: Mayo Clinic
Sex: All
Age: 18 - 70+
Code: NCT07817706
Recruiting
Active & Responsive
A Study of MX006 in Patients With Advanced and/or Metastatic Tumors Known to Express B7-H3
for
Advanced and/or Metastatic Solid Tumors Known to Express B7-H3
Location: Baltimore MD, Fairfax VA, Sarasota FL, Atlanta GA,
Sponsor: Myricx Pharma Limited
Sex: All
Age: 18+
Code: NCT07807241
Phase 1, Recruiting
Active & Responsive
Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma
Optimizing Ancillary Therapies With Immune Checkpoint Inhibitors for Solid Tumors (OAT ICI)
for
Solid Tumors
Location: Lexington KY
Sponsor: Val Adams
Sex: All
Age: 18 - 70+
Code: NCT07661459
Phase 2, Recruiting
Active & Responsive
A Study of Navlimetostat (BMS-986504) Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
for
Solid Tumors
Location: New York NY, Baltimore MD, Atlanta GA, Houston TX
Sponsor: Bristol-Myers Squibb
Sex: All
Age: 18+
Code: NCT07492680
Phase 2, Recruiting
Active & Responsive
PDT For Induction Therapy For Head And Neck Cancer
for
Squamous Cell Carcinoma,
Location: Boston MA
Sponsor: Massachusetts General Hospital
Sex: All
Age: 18+
Code: NCT07214987
Phase 2, Recruiting
Active & Responsive
Capturing Food Intake in Patients Undergoing Radiation Therapy for Cancer
for
Cancer, Radiation Therapy, Dietary Intake
Location: Minneapolis MN
Sponsor: University of Minnesota
Sex: All
Age: 18+
Code: NCT07682714
Recruiting
Active & Responsive
Metronomic Gemcitabine, Mitomycin C, and Thalidomide for Advanced Solid Tumors
for
Solid Tumor Cancer
Location: Santa Monica CA
Sponsor: Sarcoma Oncology Research Center, LLC
Sex: All
Age: 18+
Code: NCT07671534
Phase 2, Recruiting
Active & Responsive
The Impact of CAR-T Cell Therapy on Fertility; A Patient Survey
for
Cancer
Location: Rye NY
Sponsor: Lymphoma and Leukemia Society
Sex: All
Age: 18+
Code: NCT07173322
Recruiting
Active & Responsive
A Study of NEOK001, a B7-H3 and ROR1 Targeting Bispecific ADC in Participants With Select Solid Tumors
for
Locally Advanced (Unresectable) or Metastatic Solid Tumors
Location: New York NY, Fairfax VA, Nashville TN, Houston TX,
Sponsor: NEOK Bio, Inc.
Sex: All
Age: 18+
Code: NCT07612176
Phase 1, Recruiting
Active & Responsive
A Study of IDE849 in Patients With DLL3 Expressing Tumors Including Small Cell Lung Cancer