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Paid Clinical Trials Irvine

Discover 3,580 paid clinical trials in Irvine, California. Search by condition or phase to find a research study near you that matches your needs across various therapeutic areas.

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A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

for
Non-Small Cell Lung Cancer (NSCLC)
Location: Fountain Valley CA, Beverly Hills CA, Bullhead City AZ,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT07361510

Phase3, Recruiting

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

for
AML, AML With Mutated NPM1, Hematologic Malignancy, KMT2Ar,
Location: Orange CA, Los Angeles CA, Gilbert AZ, San Francisco CA,
Sponsor: Kura Oncology, Inc.

Sex: All

Age: 18+

Code: NCT06001788

Phase1, Recruiting

An Extension Study for Patients Previously Enrolled in Studies With Pelabresib

for
Hematologic Malignancy, Solid Tumor, Advanced Malignancies
Location: Los Angeles CA, Chicago IL, Ann Arbor MI,
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06401356

Phase3, Recruiting

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

for
Non-small Cell Lung Cancer (NSCLC)
Location: Burbank CA, Phoenix AZ, Reno NV, Grand Junction CO,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06170788

Phase3, Recruiting

Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms

for
T-Cell Neoplasm, Lymphoproliferative Disorders
Location: Duarte CA, Ann Arbor MI, Columbus OH, Durham NC
Sponsor: University of Michigan Rogel Cancer Center

Sex: All

Age: 18+

Code: NCT04858256

Phase2, Recruiting

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A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma

for
Hypogammaglobulinemia, Bacterial Infections,
Location: Huntington Park CA, Canton OH, St. Petersburg FL,
Sponsor: Grifols Therapeutics LLC

Sex: All

Age: 18+

Code: NCT05645107

Phase3, Recruiting

Study of ALTO-300 in MDD

for
Major Depressive Disorder
Location: Mission Viejo CA, Bellflower CA, Los Angeles CA,
Sponsor: Alto Neuroscience

Sex: All

Age: 18 - 70

Code: NCT05922878

Phase2, Recruiting

Registry for Intra-Operative Radiotherapy During Breast Conserving Surgery in Patients With Early Stage Breast Cancer

for
Early-stage Breast Cancer, Breast Carcinoma in Situ,
Location: Santa Monica CA
Sponsor: Saint John's Cancer Institute

Sex: All

Age: 18+

Code: NCT04603209

Recruiting

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Los Angeles CA, Dallas TX, Houston TX, Ann Arbor MI,
Sponsor: LigaChem Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT05941507

Phase1, Phase2, Recruiting

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

for
Ovarian Cancer
Location: Burbank CA, La Jolla CA, Palo Alto CA,
Sponsor: Daiichi Sankyo

Sex: Female

Age: 18+

Code: NCT06819007

Phase3, Recruiting

Shorter Versus Extended Course of Antibiotic Therapy for Necrotizing Soft Tissue Infections

for
Necrotizing Soft Tissue Infection
Location: Orange CA
Sponsor: University of California, Irvine

Sex: All

Age: 18+

Code: NCT06002607

Recruiting

Study of ATX-01 in Participants With DM1

for
Myotonic Dystrophy 1
Location: Los Angeles CA, Fairway KS, Iowa City IA,
Sponsor: ARTHEx Biotech S.L.

Sex: All

Age: 18 - 64

Code: NCT06300307

Phase1, Phase2, Recruiting

Contrast Enhanced Ultrasound Medical Imaging for Identifying Breast Masses

for
Breast Carcinoma
Location: Los Angeles CA
Sponsor: University of Southern California

Sex: Female

Age: 18+

Code: NCT06171607

Phase1, Recruiting

A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation

for
Atrial Fibrillation
Location: Fountain Valley CA, Ventura CA, Murray UT, Austin TX,
Sponsor: Biosense Webster, Inc.

Sex: All

Age: 18 - 70+

Code: NCT07523750

Recruiting

A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer

for
Prostatic Neoplasms, Castration-Resistant
Location: Fountain Valley CA, Los Alamitos CA, Riverside CA,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT07225946

Phase3, Recruiting

Open-Label, Dose-Escalation With Expansion to Assess the Safety, Tolerability, and PK of TRE-515 in Subjects With Solid Tumors

for
Solid Tumor, Adult, Oncology
Location: Santa Monica CA, Huntersville NC
Sponsor: Trethera

Sex: All

Age: 18+

Code: NCT05055609

Phase1, Recruiting

A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma

for
Plasma Cell Myeloma Refractory
Location: Los Angeles CA, West Hollywood CA, Phoenix AZ,
Sponsor: Sanofi

Sex: All

Age: 18+

Code: NCT06356571

Phase2, Recruiting

Aspirin for Postpartum Patients With Preeclampsia

for
Preeclampsia Postpartum
Location: Long Beach CA
Sponsor: MemorialCare Health System

Sex: Female

Age: 18+

Code: NCT05924971

Phase2, Recruiting

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

for
Heart Failure, Left Ventricular Systolic Dysfunction
Location: San Bernardino CA, Los Angeles CA, Palo Alto CA,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 0 - 17

Code: NCT05714085

Phase2, Phase3, Recruiting

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

for
Triple-Negative Breast Cancer
Location: Fountain Valley CA, Oceanside CA, La Jolla CA,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06393374

Phase3, Recruiting