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Alzheimer's Tau Platform: Master Protocol

for
Preclinical Alzheimer's Disease, Alzheimer Disease,
Location: Providence RI, Nashville TN, San Francisco CA
Sponsor: Paul S. Aisen

Sex: All

Age: 50 - 70+

Code: NCT06957418

Phase2, Recruiting

A Study to Evaluate How Pozelimab + Cemdisiran Combination Therapy Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Whose Current Treatment is Not Working Efficiently

for
Paroxysmal Nocturnal Hemoglobinuria
Location: Levis
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07154745

Phase3, Recruiting

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

for
Brain Cancer, Brain Metastases, Melanoma, Lung Cancer,
Location: Boston MA
Sponsor: Brigham and Women's Hospital

Sex: All

Age: 18+

Code: NCT04899908

Phase2, Recruiting

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

for
Renal Cell Carcinoma
Location: Westbrook ME, Baltimore MD, Charlotte NC, Knoxville TN,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07227402

Phase3, Recruiting

Preoperative Hemodialysis Timing in Patients With End-Stage Kidney Disease: The POD-ESKD Pilot Trial

for
Perioperative Management, End Stage Kidney Disease (ESRD),
Location: Stanford CA
Sponsor: Stanford University

Sex: All

Age: 18+

Code: NCT07339202

Recruiting

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D07001 Softgel-Capsules and Capecitabine Combination Therapy in Patients With Advanced Biliary Tract Cancer

for
Biliary Tract Cancer (BTC)
Location: Miami Beach FL, Cleveland OH, Tucson AZ
Sponsor: InnoPharmax Inc.

Sex: All

Age: 18+

Code: NCT06622057

Phase3, Recruiting

Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy

for
Obesity & Overweight, Type 2 Diabetes,
Location: Buffalo NY
Sponsor: State University of New York at Buffalo

Sex: All

Age: 18 - 60

Code: NCT07641361

Recruiting

Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

for
Astrocytoma, IDH-Mutant, Grade 2,
Location: New Haven CT, Trumbull CT, Mineola NY, New York NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06860594

Phase1, Recruiting

The Effects of Stellate Ganglion Block Sleep in U.S. Active Duty Service Members and Veterans Receiving Prolonged Exposure Therapy for PTSD

for
Post Traumatic Stress Disorder PTSD
Location: Killeen TX, San Antonio TX
Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All

Age: 18 - 65

Code: NCT07667309

Recruiting

Wearable Sensory Prosthesis to Improve Coordination, Walking, and Physical Activity

for
Peripheral Neuropathy With Type 2 Diabetes,
Location: Jacksonville FL
Sponsor: RxFunction Inc.

Sex: All

Age: 60+

Code: NCT07554443

Recruiting

A Phase 1/2 Study of D3S-002 as Monotherapy or Combination Therapy in Adult Subjects With Advanced Solid Tumors With MAPK Pathway Mutations

for
Advanced Solid Tumors With MAPK Pathway Mutations
Location: Detroit MI, Nashville TN, Houston TX
Sponsor: D3 Bio (Wuxi) Co., Ltd

Sex: All

Age: 18+

Code: NCT05886920

Phase1, Phase2, Recruiting

Evaluating a Decreased Dose of Radiation Therapy to the Elective Neck for the Treatment of HPV-Related Oropharyngeal Cancer, ENLIGHT Trial

for
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Chicago IL, Warrenville IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT07178301

Phase2, Recruiting

Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer

for
Astrocytoma, IDH-Mutant, Grade 3
Location: Bath ME, Portland ME, Scarborough ME, Sanford ME,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 12+

Code: NCT07215910

Phase3, Recruiting

Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous SCC for Immunocompromised Patients

for
Squamous Cell Carcinoma, Alpha Radiation, Immunocompromised,
Location: Cooperstown NY, Hollywood FL, Atlanta GA, Gilbert AZ,
Sponsor: Alpha Tau Medical LTD.

Sex: All

Age: 18+

Code: NCT06615635

Recruiting

A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

for
Amyotrophic Lateral Sclerosis (ALS),
Location: Philadelphia PA, Philadelphi PA, Hershey PA
Sponsor: University of Pennsylvania

Sex: All

Age: 18+

Code: NCT07071935

Phase2, Recruiting

Using Light Therapy for Mild Cognitive Impairment

for
Mild Cognitive Impairment (MCI), Amyloid Pathology
Location: Oklahoma City OK
Sponsor: University of Oklahoma

Sex: All

Age: 55 - 70+

Code: NCT07651787

Recruiting

Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging

for
MRI Sedation, Pediatric Sedation, Propofol Dosage,
Location: Boston MA
Sponsor: Boston Children's Hospital

Sex: All

Age: 1 - 12

Code: NCT07369128

Recruiting

A Study to Evaluate DJI136, a DLL3-targeted CAR-T Therapy

for
Extensive-stage Small Cell Lung Cancer (ES-SCLC)
Location: Lexington KY, Houston TX, Seattle WA
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07564401

Phase1, Phase2, Recruiting

Study of IEV407 as Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer

for
Advanced HR+/HER2- Breast Cancer
Location: New Haven CT, Toronto, Dallas TX
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07604571

Phase1, Recruiting

Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Thick Meconium Exposure

for
Neonatal Respiratory Distress Related Conditions, Meconium,
Location: Milwaukee WI
Sponsor: Medical College of Wisconsin

Sex: All

Age: 18+

Code: NCT07274527

Recruiting