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Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

for
Advanced Breast Carcinoma, Advanced Endometrial Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05092373

Phase1, Recruiting

Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors

for
Malignant Solid Tumors, Other Neoplasms Solid Tumors,
Location: Bethesda MD, Houston TX, Portland OR
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 0+

Code: NCT03739827

Recruiting

Personalized Patient Derived Xenograft (pPDX) Modeling to Test Drug Response in Matching Host

for
Colorectal Neoplasms, Colorectal Cancer, Breast Cancer,
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT02732860

Recruiting

Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy

for
Prostate Cancer, Prostate Cancer (Adenocarcinoma),
Location: Boston MA
Sponsor: Shehzad Basaria, M.D.

Sex: Male

Age: 40+

Code: NCT06957691

Phase2, Recruiting

Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases

for
Distal Bile Duct Adenocarcinoma, Gallbladder Carcinoma,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT05285358

Phase1, Recruiting

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Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

for
Metastatic Malignant Solid Neoplasm,
Location: Boston MA, Pittsburgh PA, Gainesville FL, Columbus OH,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05372614

Phase1, Recruiting

Investigating the Feasibility and Acceptability of an Innovative Interdisciplinary Supportive Care Program: Couples Coping Together Against Cancer

for
Anatomic Stage IV Breast Cancer AJCC v8, Glioblastoma,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07664579

Recruiting

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

for
Recurrent Glioblastoma,
Location: Bethesda MD
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All

Age: 18 - 70+

Code: NCT07416188

Phase1, Phase2, Recruiting

Evaluating Efficacy of B7-H3-CAR T Cells Administered at the End of Upfront Map Chemotherapy in Patients With Newly Diagnosed High-Risk Osteosarcoma

for
Pediatric Osteosarcoma
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 21

Code: NCT07428993

Phase2, Recruiting

Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

for
Advanced Biliary Tract Carcinoma,
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT07405086

Recruiting

Distance-Based Exercise to Preserve Function and Prevent Disability

for
Localized Malignant Solid Neoplasm, Anal Cancer,
Location: Boston MA, Indiana PA, Kernersville NC,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 18+

Code: NCT07059884

Recruiting

Pre-NEOSHIFT-RCC: Neoadjuvant HIF-Inhibitor Immunotherapy in RCC

for
Renal Cell Carcinoma, Kidney Cancer, Kidney Neoplasm,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT07397611

Phase2, Recruiting

Easing Scan Anxiety in Pediatric Oncology Caregivers Through Meditation-based Programs

for
Caregiver Anxiety, Caregiver Anxiety Related to Cancer Imaging,
Location: Hartford CT
Sponsor: Kimberley Roche

Sex: All

Age: 18+

Code: NCT07420101

Recruiting

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

for
Renal Cell Carcinoma (RCC),
Location: Boston MA, New Haven CT, New York NY, Hackensack NJ,
Sponsor: Exelixis

Sex: All

Age: 18+

Code: NCT05176483

Phase1, Recruiting

Identifying and Caring for Individuals With Inherited Cancer Syndrome

for
BRCA1/2-Associated Hereditary Breast and Ovarian Cancer Syndrome,
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT04494945

Recruiting

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

for
Glioblastoma, Brain Cancer, Glioblastoma Multiforme,
Location: New York NY, Miami FL
Sponsor: Baptist Health South Florida

Sex: All

Age: 18+

Code: NCT06991101

Phase2, Recruiting

Survivors Journey+

for
Pediatric Brain Tumor
Location: Columbus OH, Cincinnati OH
Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All

Age: 15 - 25

Code: NCT07321353

Recruiting

TR-002 for the Treatment of Advanced Unresectable Metastatic Solid Tumors Unresectable or Metastatic, Refractory Pancreatic Adenocarcinoma

for
Advanced Malignant Solid Neoplasm,
Location: Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT07189195

Phase1, Recruiting

A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer

for
Cutaneous Squamous Cell Carcinoma,
Location: Uniondale NY, New York NY, Middletown NJ, Montvale NJ,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05859074

Phase1, Recruiting

Pediatric Radiation Therapy Registry

for
Sarcoma, Pediatric Brain Tumors
Location: Baltimore MD, Washington D.C. DC
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 0 - 26

Code: NCT07129317

Recruiting