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Active & Responsive

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

for
Autoimmune Disease, Crohn Disease, Dermatomyositis,
Location: Boston MA, New Haven CT, Mineola NY, New York NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT03816345

Phase1, Recruiting
Active & Responsive

A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma

for
Multiple Myeloma in Relapse, Myeloma Multiple,
Location: Boston MA, Hackensack NJ, Tampa FL, Atlanta GA,
Sponsor: Kelonia Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07075185

Phase1, Recruiting
Active & Responsive

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

for
Barrett Esophagus, Gastroesophageal Reflux,
Location: Baltimore MD, Chapel Hill NC, Cleveland OH, Aurora CO
Sponsor: Case Comprehensive Cancer Center

Sex: All

Age: 50+

Code: NCT06687603

Recruiting
Active & Responsive

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

for
Central Nervous System Tumor, Diffuse Intrinsic Pontine Glioma,
Location: Seattle WA
Sponsor: Seattle Children's Hospital

Sex: All

Age: 1 - 26

Code: NCT04185038

Phase1, Recruiting
Active & Responsive

Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience Research

for
Malignant Central Nervous System Neoplasm
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06117930

Recruiting

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Active & Responsive

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

for
Glioblastoma (GBM), Newly Diagnosed Glioblastoma, GBM,
Location: Boston MA, New Haven CT, Lake Success NY, The Bronx NY,
Sponsor: Black Diamond Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07326566

Phase2, Recruiting
Active & Responsive

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Boston MA, Atlanta GA, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18 - 70+

Code: NCT06059391

Phase2, Recruiting
Active & Responsive

A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant

for
Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive,
Location: Boston MA, Atlanta GA, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18 - 70+

Code: NCT07020533

Phase1, Recruiting
Active & Responsive

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

for
Diffuse Midline Glioma (DMG), Glioblastoma,
Location: Philadelphia PA, Washington D.C. DC, Atlanta GA,
Sponsor: Sabine Mueller, MD, PhD

Sex: All

Age: 2 - 21

Code: NCT04732065

Phase1, Recruiting
Active & Responsive

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

for
Cancer, Metastatic, Cancer, Cancer of Pancreas, Cancer of Liver,
Location: Scarborough ME, Worcester MA, Hartford CT, Norwalk CT,
Sponsor: Massive Bio, Inc.

Sex: All

Age: 0+

Code: NCT03452774

Recruiting

Point-of-Care Ultrasound for Pediatric Thoracic Trauma: A Multi-Institutional Trial

for
Trauma Chest, Pediatric ALL
Location: Sacramento CA
Sponsor: Sutter Health

Sex: All

Age: 0 - 21

Code: NCT05025150

Recruiting

Efficacy of a Clinic-based, Multi- Disciplinary, Pediatric Weight Management Program

for
Body Weight Changes
Location: Burlington VT
Sponsor: University of Vermont

Sex: All

Age: 12 - 18

Code: NCT01857791

Recruiting

Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy

for
Pediatric Patients Treated With Radiation Therapy
Location: Boston MA, New York NY, Somerset NJ, Philadelphia PA,
Sponsor: Massachusetts General Hospital

Sex: All

Age: 0 - 21

Code: NCT01696721

Recruiting

Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

for
Malignant Brain Neoplasm, Malignant Solid Neoplasm,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 70+

Code: NCT06788886

Recruiting

Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

for
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS),
Location: Philadelphia PA, Hershey PA, Washington D.C. DC,
Sponsor: Nationwide Children's Hospital

Sex: All

Age: 0 - 17

Code: NCT05267821

Phase2, Phase3, Recruiting
New

B7-H3.CD28Z.CART in CNS Neoplasms

for
Central Nervous System Neoplasms, Brain Tumor,
Location: Boston MA
Sponsor: Robbie Majzner

Sex: All

Age: 2 - 21

Code: NCT07390539

Phase1, Recruiting

Somatic Mosaicism in Twins Discordant for Childhood Cancer

for
Pediatric Central Nervous System Tumor,
Location: Minneapolis MN
Sponsor: Children's Oncology Group

Sex: All

Age: 0 - 18

Code: NCT06054295

Recruiting

A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue

for
Pediatric Sarcoma, Refractory, Pediatric Sarcoma, Relapsed
Location: The Bronx NY, Philadelphia PA, Durham NC,
Sponsor: Nationwide Children's Hospital

Sex: All

Age: 2 - 40

Code: NCT05634369

Phase1, Phase2, Recruiting

GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults

for
Medulloblastoma, Central Nervous System Embryonal Tumor,
Location: Palo Alto CA
Sponsor: Stanford University

Sex: All

Age: 1 - 30

Code: NCT07087002

Phase1, Recruiting

Neoepitope-based Personalized DNA Vaccine Approach in Pediatric Patients With Recurrent Central Nervous System Tumors

for
Pediatric Recurrent Central Nervous System Tumors
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 0 - 25

Code: NCT03988283

Phase1, Recruiting