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Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400

for
Hepatocellular Carcinoma, Pancreatic Ductal Adenocarcinoma,
Location: San Antonio TX
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT06084481

Phase1, Recruiting
Featured

A Real World Study to Globally Assess Disease Burden in Adolescent and Adult Participants With Alopecia Areata, Vitiligo, or Hidradenitis Suppurativa

for
Non-Segmental Vitiligo (NSV), Alopecia Areata,
Location: Fredericton, Pointe-Claire, Markham, Richmond Hill,
Sponsor: AbbVie

Sex: All

Age: 12+

Code: NCT07136467

Recruiting
Featured

A Study to Evaluate the Safety and Effectiveness of Upadacitinib in Pediatric Participants With Alopecia Areata

for
Severe Alopecia Areata
Location: Norfolk VA, Miami FL, Fairborn OH, Indianapolis IN,
Sponsor: AbbVie

Sex: All

Age: 6 - 17

Code: NCT07772492

Phase3, Recruiting
Featured

A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants

for
Healthy Volunteer
Location: Marlton NJ, Miami FL, Maitland FL, Grayslake IL
Sponsor: AbbVie

Sex: All

Age: 65 - 70+

Code: NCT07219030

Phase1, Recruiting
Featured

A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

for
Epithelial Ovarian Cancer, Fallopian Tube Cancer,
Location: Providence RI, New Haven CT, Lebanon NH, Bay Shore NY,
Sponsor: AbbVie

Sex: Female

Age: 18+

Code: NCT06890338

Phase2, Recruiting

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Featured

Study to Assess Change in Quality of Life of Risankizumab Treatment in Adult Participants With Moderate-to-Severe Plaque Psoriasis

for
Plaque Psoriasis
Location: Saint-Jerôme, Ottawa, Belleville, Peterborough, Ajax,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT07039110

Recruiting
Featured

A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer

for
Colorectal Cancer
Location: New Haven CT, Lake Success NY, East Brunswick NJ,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT07525206

Phase3, Recruiting
Featured

A Study to Assess Safety, Tolerability, and How Single and Multiple Injections or Infusions of ABBV-313 Affects the Body of Adult Participants

for
Healthy Volunteers
Location: Grayslake IL, Anaheim CA
Sponsor: AbbVie

Sex: All

Age: 18 - 55

Code: NCT07673120

Phase1, Recruiting
Featured

An Extension Study to Assess Long-Term Safety and Efficacy of Afimkibart in Participants With Rheumatoid Arthritis

for
Rheumatoid Arthritis
Location: Tamarac FL, Tomball TX, Lake Charles LA, Houston TX
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT07620392

Phase2, Recruiting
Featured

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy

for
Diabetic Retinopathy
Location: Columbus OH, Oak Forest IL, Glendale CA
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT07588100

Phase1, Recruiting
Featured

A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease

for
Alzheimer's Disease
Location: Watertown MA, Wellington FL, Stuart FL, Winter Park FL,
Sponsor: AbbVie

Sex: All

Age: 50 - 70+

Code: NCT07599670

Phase1, Phase2, Recruiting
Featured

A Study to Assess Adverse Events and How Intravenous (IV) Pivekimab Sunirine Moves Through the Body in Pediatric Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)

for
Acute Myeloid Leukemia
Location: Valhalla NY, Atlanta GA, Nashville TN, Dallas TX,
Sponsor: AbbVie

Sex: All

Age: 0 - 17

Code: NCT07306832

Phase1, Recruiting
Featured

A Study to Evaluate the Effect of Moderate or Severe Hepatic Impairment on the Pharmacokinetics (PK) of Inavolisib

for
Hepatic Impairment
Location: Orlando FL, San Antonio TX, Lake Forest CA
Sponsor: Genentech, Inc.

Sex: All

Age: 18 - 70+

Code: NCT07144111

Phase1, Recruiting
Featured

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

for
Alzheimers Disease
Location: Halifax, Boston MA, Watertown MA, Newton MA,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 50 - 70+

Code: NCT07177352

Phase3, Recruiting
Featured

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

for
Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer
Location: Rimouski, Boston MA, Worcester MA, Hartford CT, Quebec,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT06793215

Phase3, Recruiting
Featured

RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive

for
HER2-positive Breast Cancer
Location: Norwich CT, Shirley NY, Quebec, Stony Brook NY,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT07413939

Phase2, Phase3, Recruiting
Featured

A Study to Assess Adverse Events, Change in Disease Activity, and How Oral Emraclidine Moves Through the Body in Adult Participants With Schizophrenia

for
Schizophrenia
Location: Marlton NJ, Gaithersburg MD, Little Rock AR,
Sponsor: AbbVie

Sex: All

Age: 18 - 65

Code: NCT07145918

Phase2, Recruiting
Featured

A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)

for
Multiple Myeloma
Location: Boston MA, New Haven CT, New York NY, Chapel Hill NC,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT06953960

Phase1, Phase2, Recruiting
Featured

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

for
Ulcerative Colitis
Location: London, Fresh Meadows NY, Montreal, Monroe NC,
Sponsor: Genentech, Inc.

Sex: All

Age: 18+

Code: NCT06979336

Phase2, Recruiting
Featured

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)

for
Neoplasms
Location: New Haven CT, Toronto, Sarasota FL, Houston TX,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT06884618

Phase1, Recruiting