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Head & Neck Cancer Clinical Trials

Browse 313 head & neck cancer clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer

for
Human Papillomavirus-Negative Neck Squamous Cell Carcinoma,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06997094

Phase1, Recruiting

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

for
Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Brewer ME, Stony Brook NY, Long Branch NJ,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT07195734

Phase2, Recruiting

Tongue-out Radiation Therapy (TORT) for the Mitigation of Radiotherapy-related Toxicities in Patients With Head and Neck Cancer

for
Head and Neck Carcinoma
Location: Pittsburgh PA
Sponsor: Yvonne Mowery

Sex: All

Age: 18+

Code: NCT07227792

Recruiting

Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

for
Head and Neck Squamous Cell Carcinoma,
Location: Hackensack NJ, Richmond VA, Pittsburgh PA, Atlanta GA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06980038

Phase2, Recruiting

A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

for
Squamous Cell Carcinoma of Head and Neck
Location: Boston MA, Hartford CT, New Haven CT, Mineola NY,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT07276399

Phase3, Recruiting

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Ivonescimab Before Surgery for the Treatment of Resectable Stage II-IV Head and Neck Cancer

for
Advanced Head and Neck Squamous Cell Carcinoma,
Location: Ann Arbor MI
Sponsor: University of Michigan Rogel Cancer Center

Sex: All

Age: 18+

Code: NCT07094685

Phase2, Recruiting

Geriatric Assessment and Management for Older Adults Undergoing Chemotherapy and Radiation Therapy for Head and Neck Cancer and Their Family Caregivers

for
Localized Head and Neck Carcinoma
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07225855

Recruiting

Virtual Reality 3D-Surgery Modeling to Enhance Head and Neck Cancer Surgery Quality

for
Head and Neck Squamous Cell Carcinoma
Location: Philadelphia PA
Sponsor: Thomas Jefferson University

Sex: All

Age: 18+

Code: NCT05031910

Recruiting

[212Pb]VMT-Alpha-NET in Metastatic or Inoperable Somatostatin-Receptor Positive Gastrointestinal Neuroendocrine Tumors, Pheochromocytoma/Paragangliomas, Small Cell Lung, Renal Cell, and Head and Neck Cancers

for
Sinonasal Neuroendocrine Carcinoma, Nasopharyngeal Carcinoma,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06479811

Phase1, Recruiting

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

for
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Boston MA, Saint Johnsbury VT, Lebanon NH, The Bronx NY,
Sponsor: NRG Oncology

Sex: All

Age: 18+

Code: NCT06532279

Phase2, Recruiting

Virtual Reality Interventions for the Improvement of Depression, Anxiety and Pain in Patients With Head and Neck Cancer and Caregivers

for
Head and Neck Carcinoma
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT06985784

Recruiting

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

for
Head and Neck Squamous Cell Carcinoma,
Location: Damariscotta ME, Bath ME, Augusta ME, Brunswick ME,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 18+

Code: NCT06992427

Phase3, Recruiting

Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer

for
HNSCC, HNSCC,Larynx, Pharynx and Oral Cavity,
Location: Nashville TN
Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All

Age: 18+

Code: NCT06819228

Phase1, Recruiting

Web-Based Program in Helping Patients With Head and Neck Cancer Adhere to Swallowing Exercises and Coping Strategies

for
Throat Carcinoma
Location: Houston TX, Fort Worth TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04003051

Phase2, Recruiting

Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer

for
Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: The Bronx NY, Newark NJ, New Brunswick NJ, Baltimore MD,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05172245

Phase1, Recruiting

Evaluating 111In Panitumumab for Nodal Staging in Head and Neck Cancer

for
Head and Neck Squamous Cell Carcinoma,
Location: Nashville TN
Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All

Age: 19+

Code: NCT05901545

Phase1, Recruiting

Evaluating the Use of Dual Imaging Techniques for Detection of Disease in Patients With Head and Neck Cancer

for
Head and Neck Squamous Cell Carcinoma,
Location: Nashville TN
Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All

Age: 19+

Code: NCT05945875

Phase1, Recruiting

A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer

for
Squamous Cell Carcinoma of Head and Neck
Location: Boston MA, New Haven CT, New Brunswick NJ, Baltimore MD,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT06385080

Phase1, Phase2, Recruiting
New

SKL35501 With SKL35502 Imaging in Adults With NTSR1 Positive Advanced Solid Tumors

for
Selected Advanced Solid Tumors, Colorectal Cancer (CRC),
Location: Glen Burnie MD
Sponsor: SK Life Science, Inc.

Sex: All

Age: 18+

Code: NCT07812805

Phase1, Recruiting

Study of XB010 in Subjects With Solid Tumors

for
Locally Advanced or Metastatic Solid Tumors,
Location: The Bronx NY, Washington D.C. DC, Fairfax VA,
Sponsor: Exelixis

Sex: All

Age: 18+

Code: NCT06545331

Phase1, Recruiting