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Head & Neck Cancer Clinical Trials

Browse 313 head & neck cancer clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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A Study of MT-4561 in Patients With Various Advanced Solid Tumors

for
Head and Neck Squamous Cell Carcinoma (HNSCC),
Location: Columbus OH, Grand Rapids MI, Houston TX,
Sponsor: Tanabe Pharma America, Inc.

Sex: All

Age: 18+

Code: NCT06943521

Phase1, Phase2, Recruiting
New

A Study Evaluating Ficerafusp Alfa (BCA101) QW in Combination With Pembrolizumab vs Alternative Ficerafusp Alfa Dosing in 1L R or M HNSCC

for
Metastatic Head and Neck Squamous Cell Carcinoma,
Location: Tyler TX
Sponsor: Bicara Therapeutics

Sex: All

Age: 18+

Code: NCT07807163

Phase2, Recruiting

Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC

for
Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC),
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT05414032

Phase2, Recruiting

5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCC

for
Squamous Cell Carcinoma of Head and Neck
Location: New Haven CT
Sponsor: Barbara Burtness

Sex: All

Age: 18+

Code: NCT05317000

Phase2, Recruiting

HN-QUEST: A Study of Head and Neck Imaging Biomarkers

for
Head and Neck Squamous Cell Carcinoma
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT05919290

Recruiting

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A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

for
Locally Advanced Head and Neck Squamous Cell Carcinoma
Location: Fairhaven MA, Boston MA, Stony Brook NY, New York NY,
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT06129864

Phase3, Recruiting

Pembrolizumab and Hypofractionated Radiation Therapy for the Treatment of Mucosal Melanoma

for
Mucosal Melanoma of the Head and Neck
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 16+

Code: NCT04318717

Phase2, Recruiting

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

for
Head and Neck Squamous Cell Carcinoma
Location: Boston MA, New York NY, Philadelphia PA, Baltimore MD,
Sponsor: Tempus AI

Sex: All

Age: 18+

Code: NCT06163534

Recruiting

A Study of Head and Neck MRI and Tumor Microenvironment Biomarkers

for
Squamous Cell Carcinoma of Head and Neck
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT06085781

Recruiting

Losartan, Pembrolizumab and Stereotactic Body Radiation Therapy for the Treatment of Patients With Locally Recurrent, Refractory or Oligometastatic Head and Neck Squamous Cell Carcinoma

for
Locally Recurrent Head and Neck Squamous Cell Carcinoma,
Location: Aurora CO, Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT06211335

Phase1, Recruiting

3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized Trial

for
Head and Neck Squamous Cell Carcinoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05674396

Phase2, Recruiting

HN-BIO 02: A Phase II Randomized Study of the Effects of Delayed Elective Radiotherapy on Head and Neck MRI and Immune Response Biomarkers

for
Squamous Cell Carcinoma of Head and Neck
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT06487403

Recruiting

Palbociclib and Cetuximab Versus Cetuximab Monotherapy for Patients With CDKN2A-altered, HPV-unrelated Head and Neck Squamous Cell Carcinoma Who Experienced Disease Progression on a PD-1/L1 Inhibitor

for
HPV-unrelated Head and Neck Squamous Cell Carcinoma
Location: St Louis MO, Fargo ND, Sioux Falls SD
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT04966481

Phase3, Recruiting

A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases

for
Recurrent Head and Neck Squamous Cell Carcinoma
Location: Providence RI, Philadelphia PA, Miami FL, Tampa FL,
Sponsor: Rakuten Medical, Inc.

Sex: All

Age: 18+

Code: NCT06699212

Phase3, Recruiting

A Phase II Study of ACR-368 and Low Dose Gemcitabine in R/M HNSCC

for
Head and Neck Squamous Cell Carcinoma
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT06597565

Phase2, Recruiting

Pulsed Dose Chemotherapy Plus Pembrolizumab in Recurrent/Metastatic HNSCC

for
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC),
Location: Pittsburgh PA
Sponsor: Dan Zandberg

Sex: All

Age: 18+

Code: NCT06052839

Phase2, Recruiting

A Study of the Use of Fat Flap Reconstruction to Reduce Neck Injury After Cancer Treatment

for
Head and Neck Squamous Cell Carcinoma
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05889091

Recruiting

Customized 3D Printed Oral Stents During Head and Neck Radiotherapy

for
Head and Neck Carcinoma, Malignant Parotid Gland Neoplasm,
Location: Camden NJ, Jacksonville FL, Indianapolis IN, Houston TX,
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04870762

Phase2, Recruiting

Low-Dose Weekly vs High-Dose Cisplatin

for
Locally Advanced Head and Neck Squamous Cell Carcinoma
Location: Toronto, Hamilton
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All

Age: 18+

Code: NCT03649048

Recruiting

Comparison of 89Zr Panitumumab and (18)F-Fluorodeoxyglucose to Identify Head and Neck Squamous Cell Carcinoma

for
Head and Neck Squamous Cell Carcinoma
Location: Birmingham AL
Sponsor: University of Alabama at Birmingham

Sex: All

Age: 18+

Code: NCT05183048

Early_phase1, Recruiting