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Head & Neck Cancer Clinical Trials

Browse 313 head & neck cancer clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400

for
Hepatocellular Carcinoma, Pancreatic Ductal Adenocarcinoma,
Location: San Antonio TX
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT06084481

Phase1, Recruiting
Active & ResponsiveNew

A Pilot Study of Ultra-High Dose Rate (ConformalFLASH®), for Reirradiation of Carcinoma of the Head and Neck

for
Head and Neck Cancer
Location: Philadelphia PA
Sponsor: IBA Proton Therapy, Inc.

Sex: All

Age: 18+

Code: NCT07644585

Recruiting
Active & Responsive

Efficacy and Safety Evaluation of VS-101 in Combination With Chemoradiotherapy in Patients With Head and Neck Cancer

for
Head and Neck Cancer Squamous Cell Carcinoma
Location: New Haven CT, Manhattan NY
Sponsor: VSPharmTech Co.,Ltd.

Sex: All

Age: 18+

Code: NCT06959082

Phase2, Recruiting
Active & Responsive

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

for
Head and Neck Cancer, Squamous Cell Carcinoma,
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18+

Code: NCT07209189

Phase2, Recruiting
Active & Responsive

Head and Neck Cancer Study Project in the Geriatric Population

for
Head and Neck Neoplasms
Location: Providence RI
Sponsor: Brown University

Sex: All

Age: 65+

Code: NCT06998069

Phase3, Recruiting

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Active & Responsive

PDT For Induction Therapy For Head And Neck Cancer

for
Squamous Cell Carcinoma,
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18+

Code: NCT07214987

Phase2, Recruiting
Active & Responsive

Liquid Biopsy Evaluation and Repository Development at Princess Margaret

for
Cancer, Breast Cancer, Lung Cancer, Colon Cancer,
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT03702309

Recruiting
Active & Responsive

Improving Care for Rural Patients With Solid Tumors

for
Lung Cancer, Head and Neck Cancer, Thyroid Cancer,
Location: Greeley CO, Aurora CO, Loveland CO, Fort Collins CO,
Sponsor: University of Colorado, Denver

Sex: All

Age: 18 - 70+

Code: NCT04916990

Recruiting
Active & Responsive

Clonal Hematopoiesis Chemotherapy and Radiation Effects Study

for
Lung Cancer (Diagnosis), Osteochondroma, Spitz Nevus,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT07675967

Recruiting
Active & Responsive

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

for
Head and Neck Carcinoma, Adenoid Cystic Carcinoma, Lung Cancer,
Location: Hartford CT, New York NY, Englewood NJ, Florham Park NJ,
Sponsor: VM Oncology, LLC

Sex: All

Age: 18 - 70+

Code: NCT03556228

Phase1, Phase2, Recruiting
Active & Responsive

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

for
Clinical Stage III Cutaneous Melanoma AJCC v8,
Location: Springfield MA, Saint Johnsbury VT, Lebanon NH,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05136196

Phase2, Recruiting
Active & Responsive

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

for
Metastatic Head and Neck Squamous Cell Carcinoma,
Location: Boston MA, Saint Johnsbury VT, Lebanon NH, Commack NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06589804

Phase3, Recruiting
Active & Responsive

Candida Therapeutic Vaccine in Head and Neck Cancer Patients to Reduce Recurrence

for
Squamous Cell Carcinoma of Head and Neck
Location: Mineola NY, New York NY, Little Rock AR,
Sponsor: University of Arkansas

Sex: All

Age: 18 - 70+

Code: NCT05952934

Phase2, Recruiting
Active & Responsive

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

for
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Stony Brook NY, Wilmington DE, Chadds Ford PA,
Sponsor: NRG Oncology

Sex: All

Age: 18+

Code: NCT07441681

Phase3, Recruiting
Active & Responsive

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

for
Solid Tumor, Adult, Colorectal Cancer, Non-Small Cell Lung,
Location: New York NY, Jacksonville FL, Tampa FL, Columbus OH,
Sponsor: A2 Biotherapeutics Inc.

Sex: All

Age: 18+

Code: NCT06682793

Phase1, Phase2, Recruiting
Active & Responsive

TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer

for
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT06868433

Phase1, Recruiting
Active & Responsive

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

for
Recurrent Head and Neck Squamous Cell Carcinoma,
Location: Boston MA, Waterford CT, New Haven CT, Stony Brook NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT04671667

Phase2, Recruiting
Active & Responsive

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

for
Metastatic Head and Neck Squamous Cell Carcinoma,
Location: Boston MA, Providence RI, New York NY, Newark NJ,
Sponsor: Bicara Therapeutics

Sex: All

Age: 18+

Code: NCT06788990

Phase2, Phase3, Recruiting
Active & Responsive

Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]

for
Lymphedema of the Head and Neck
Location: Philadelphia PA, Nashville TN
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 18+

Code: NCT06125743

Recruiting
Active & Responsive

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

for
Oropharyngeal Squamous Cell Carcinoma, Carcinoma, Squamous Cell,
Location: Chapel Hill NC, North Charleston SC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT04564989

Recruiting