A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)
A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus
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A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes Mellitus
A Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity
What are obesity clinical trials?
Obesity clinical trials are research studies that test different approaches to managing weight and improving related health outcomes, like behavioral programs, dietary strategies, medical devices, or other interventions. Researchers run these studies to better understand what actually helps people manage weight long-term, and how those approaches affect overall health, from blood sugar to blood pressure.
Learn more in our article: Obesity and Clinical Trials: Weight Loss Research Explained.
The importance of clinical trials in obesity research
Obesity clinical trials matter because obesity is closely linked to so many other health conditions, including diabetes, high blood pressure, and heart disease. And there's still no single approach that works for everyone. By testing different strategies across many people, researchers can find safer, more effective options and better understand why weight management works differently from person to person.
For participants, taking part in an obesity clinical trial can mean closer support and monitoring, along with the chance to contribute to research that could shape how obesity is understood and managed in the future.
Types of obesity clinical trials
Obesity affects people in different ways and for different reasons, so research in this space takes several different approaches, from lifestyle-based programs to medical and surgical options.Because of that, most obesity and weight loss clinical trials fall into a few general categories.
Behavioral and lifestyle trials
These trials test structured programs built around diet, physical activity, and behavior change, things like coaching, digital tracking tools, or commercial weight-loss programs to see which approaches help people manage their weight over the long term.
Participants usually include adults or children working on weight management through lifestyle changes alone, often as a first step before considering medication or surgery, or as a comparison group in larger studies.
Medication trials
These trials look at how specific compounds affect weight, often by studying their impact on appetite, blood sugar, or metabolism. Much of the current research in this space focuses on drug classes that influence hunger signals and blood sugar regulation, comparing them to each other or to a placebo over time.
Participants are usually adults with a higher body mass index, sometimes alongside related conditions like type 2 diabetes, and studies often track how weight and related health markers change over the course of the study.
Surgical and device trials
These trials look at bariatric surgery and weight-loss devices, such as gastric balloons, comparing different procedures to one another or examining how they perform against non-surgical approaches over the longer term.
Participants typically include adults with more significant weight-related health risks who are considering or have already had a procedure, and studies often follow them for months or years afterward to track weight, health markers, and any complications.
Quality of life trials
These trials focus on how obesity and its management affect a person's day-to-day life, like energy levels, mental health, mobility, and body image, rather than weight alone.
Participants often include people who've gone through surgery, are in a lifestyle program, or are managing weight long-term, and studies might explore things like counseling, peer support, or program design changes meant to make weight management easier to live with.
Who can participate in obesity clinical trials?
Eligibility for participating in an obesity clinical trial varies depending on the specific study, but generally, individuals with a higher body mass index or those at risk of weight-related health complications may qualify. Trials may target different groups, from adults managing weight through lifestyle changes alone to those considering, or who have already had, bariatric surgery.
For most trials, eligibility criteria often include factors like age, BMI, medical history, current health status, and prior weight-management approaches. Some trials also seek healthy volunteers for comparison.
What to expect in an obesity clinical trial
When participating in an obesity clinical trial, participants can expect to go through a thorough screening process to make sure they meet the study's specific inclusion and exclusion criteria. Following this, a detailed informed consent will be provided, explaining the study's purpose, procedures, risks, and benefits.
During the trial, participants may follow a specific program, receive an investigational medication or placebo, or continue with standard care, alongside regular check-ins, measurements, and assessments to track their weight and overall health over time.
Worried about the risks of participating in a clinical trial? Delve into our comprehensive guide to gain insights into the potential outcomes of participating. Learn about potential risks, benefits, and safety considerations to make an informed decision about your participation in a clinical trial.
How long do obesity clinical trials typically last?
An obesity clinical trial duration depends on what's being studied. Behavioral and lifestyle trials might run anywhere from a few weeks to several months, while trials looking at medications or drug compounds often run for a year or more. Many major weight loss clinical trials last around 68 to 72 weeks for the main study period, sometimes with additional monitoring afterward. Surgical trials tend to run the longest, since researchers often follow participants for months or even years after a procedure to track weight and health outcomes over time.
How to enroll in a clinical trial for obesity
Enrolling in an obesity clinical trial through our platform is a straightforward and user-friendly process. Here's how to get started:
- Identify Your Trial: Use our intuitive search bar or filter options to locate obesity clinical trials currently enrolling. This first step simplifies the process of finding relevant research studies tailored to your needs.
- Select Your Preferred Location: To find obesity clinical trials near you, simply input your preferred location into the dedicated filter bar on the left-hand side of the page.
- Explore Study Details: For in-depth information about each study, simply click the “Learn More” button. This will provide you with comprehensive details about the trial, including objectives, procedures, and eligibility criteria.
- Complete the Health Profile: After clicking on the “Get started” button you will be taken to our efficient 5-step application process to provide important health information. This helps us match you with the clinical trial that best fits your needs.
- Submit the Application: After completing the application, send it in. A clinical trial coordinator will review it and contact you regarding the possibility of participation.