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Oncology Clinical Trials

Browse 8,122 oncology clinical trials enrolling across the United States and Canada. 219 people applied to oncology studies last month. Search by city or state to find one near you.

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Pembrolizumab Administered Via the Sofusa® DoseConnect™ in Patients With Relapsed/Refractory Cutaneous T-cell Lymphoma.

for
Mycosis Fungoides
Location: Duarte CA
Sponsor: Sorrento Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT04118868

Phase 1, Recruiting

Micro-ultrasound-Guided Focal Laser Ablation for Intermediate-Risk Prostate Cancer: Safety & Effectiveness

for
Prostate Cancer (Adenocarcinoma),
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: Male

Age: 40 - 70+

Code: NCT07339943

Recruiting

The Sleep After Breast Cancer (ABC) Study - Examining Sleep Changes and Biomarkers Among Breast Cancer Patients

for
Anatomic Stage I Breast Cancer AJCC v8,
Location: Columbus OH
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT07341503

Recruiting

Genetically Engineered Cells (FH-FOLR1 ST CAR T Cells) for the Treatment of Advanced Refractory or Recurrent/Progressive Osteosarcoma, FIERCe Trial

for
Advanced Osteosarcoma, Recurrent Osteosarcoma,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 1 - 70+

Code: NCT07227571

Phase 1, Recruiting

Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study

for
HER2-positive Breast Cancer, LMD
Location: Ottawa, Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18+

Code: NCT06016387

Phase 2, Recruiting

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An Evaluation of Dose-escalation for Intrathoracic Tumours

for
Lung Cancers
Location: Saint John, Waterloo, London, Kelowna
Sponsor: Chris Goodman

Sex: All

Age: 18+

Code: NCT06794125

Recruiting

Exercise and Cognitive (Brain) Function in Breast Cancer Patients Getting Chemotherapy After Breast Surgery

for
Breast Cancer
Location: Toronto
Sponsor: University of Toronto

Sex: Female

Age: 18 - 65

Code: NCT04616300

Recruiting

Familial Investigations of Childhood Cancer Predisposition

for
Acute Leukemia, Adenomatous Polyposis, Adrenocortical Carcinoma,
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0+

Code: NCT03050268

Recruiting

A Proof of Concept Trial Investigating Safety and Efficacy of APG-157 in Oral Dysplasia

for
Oropharyngeal Dysplasia, Oral Cavity Dysplasia,
Location: Miami FL
Sponsor: Elizabeth J Franzmann

Sex: All

Age: 18+

Code: NCT05865028

Phase 2, Recruiting

Evaluating Tolerability of ePUHRT With Brachytherapy Boost

for
Prostate Cancer
Location: Indianapolis IN
Sponsor: Indiana University

Sex: Male

Age: 18+

Code: NCT06817668

Recruiting

DISCOVERY: Evaluating a Decision Support Tool for Adults Seen in Hematology/Oncology Clinics

for
Hematologic Malignancies, Lymphoma, Multiple Myeloma, Leukemia,
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 60+

Code: NCT06296368

Recruiting

Molecular Characterization of Neuroblastic Tumor: Correlation With Clinical Outcome

for
Neuroblastoma
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 0+

Code: NCT00588068

Recruiting

Chemoimmunotherapy Combined With Hyperthermia and Spatially-Fractionated Radiotherapy in Advanced Biliary Tract Cancer

for
Biliary Tract Cancer, Cholangiocarcinoma
Location: Baltimore MD
Sponsor: University of Maryland, Baltimore

Sex: All

Age: 21+

Code: NCT06546969

Phase 1, Recruiting

A Study of Zedoresertib (Debio 0123) in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Zedoresertib (Debio 0123) in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

for
Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype,
Location: New York NY, Chicago IL, Houston TX, Dallas TX,
Sponsor: Debiopharm International SA

Sex: All

Age: 18+

Code: NCT05765812

Phase 1, Phase 2, Recruiting

Checkpoint Inhibition In Pediatric Hepatocellular Carcinoma

for
Hepatocellular Carcinoma, Childhood, Fibrolamellar Carcinoma,
Location: Boston MA, Cincinnati OH, Houston TX, San Francisco CA
Sponsor: Allison O'Neill, MD

Sex: All

Age: 0 - 30

Code: NCT04134559

Phase 2, Recruiting

Molecular Detection of Advanced Neoplasia in Pancreatic Cysts

for
Pancreas Cyst
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 70+

Code: NCT03855800

Recruiting

Nerve Grafting Technique to Preserve Erectile Function in Patients Undergoing Robotic Assisted Radical Prostatectomy

for
Prostate Cancer, Erectile Dysfunction
Location: Montreal
Sponsor: Sir Mortimer B. Davis - Jewish General Hospital

Sex: Male

Age: 18+

Code: NCT06521710

Recruiting

Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 0 - 39

Code: NCT05800210

Phase 2, Recruiting

Phase II Open-label Trial of Neoadjuvant Immunochemotherapy for Resectable Non-metastatic Colon cancER: NICER

for
Stage I Colon Cancer, Stage II Colon Cancer,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 18 - 70+

Code: NCT05870800

Phase 2, Recruiting

Regorafenib Combined With Fulvestrant in Recurrent Low-Grade Serous Ovarian Cancer

for
Ovarian Cancer, Serous Ovarian Cancer
Location: Cleveland OH
Sponsor: Sarah K. Lynam MD

Sex: Female

Age: 18+

Code: NCT05113368

Phase 2, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer