A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251
A Study to Evaluate Glofitamab Monotherapy and Glofitamab + Chemoimmunotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Mature B-Cell Non-Hodgkin Lymphoma
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
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A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
A Study to Assess Intravenous (IV) Telisotuzumab Adizutecan in Combination With Fluorouracil, Folinic Acid, and Oxaliplatin (FOLFOX) Compared to Standard of Care in Adult Participants With First-Line Metastatic Pancreatic Ductal Adenocarcinoma
Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
A Study to Evaluate the Optimal Dose, Adverse Events and Change in Disease Activity of Intravenous ABBV-706 in Combination With Atezolizumab Versus Standard of Care as First-Line Treatment in Adult Participants With Previously Untreated Extensive Stage Small Cell Lung Cancer
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
Popular cities in Missouri
With its expansive healthcare network and renowned medical research institutions, Missouri is a central hub for a diverse range of clinical trials. Leading organizations such as Washington University School of Medicine in St. Louis, the University of Missouri Health Care, and St. Louis University are at the forefront of groundbreaking studies. These institutions drive innovation in medical research and offer unique opportunities for participants to engage in cutting-edge clinical trials, contributing to advancements in healthcare both locally and nationwide.
Why choose Missouri for clinical trials?
Missouri has a diverse population which ensures a wide variety of participants can take part in clinical trials, enhancing the accuracy, applicability, and validity of clinical research findings. The state is also home to a thriving research environment, with a strong emphasis on medical innovation and cutting-edge studies led by world-class institutions.
By choosing to participate in a clinical trial in Missouri, individuals contribute to critical advancements in medical research while benefiting from a well-established and supportive clinical research infrastructure.
Common conditions studied in Missouri
Missouri is well-known for conducting a wide range of clinical trials, particularly in key areas like oncology, neurodevelopmental disorders, and cardiovascular health.
Cancer
Missouri is home to some of the nation’s most advanced cancer research institutions, like the Siteman Cancer Center in St. Louis, which is recognized across the country for its comprehensive cancer research and clinical trials. Studies here focus on a variety of cancers, including breast, lung, and prostate cancer.
The state’s oncology trials often investigate innovative treatments such as immunotherapy, gene therapy, precision medicine, and personalized medicine. Missouri also has an increasing number of clinical trials exploring treatments for more rare cancers like pancreatic or ovarian cancer, as well as therapies to mitigate the side effects of traditional treatments like chemotherapy.
Neurodevelopmental disorders
Missouri plays a significant role in neurodevelopmental disorder research, including autism. Much of this research is carried out through the Thompson Center for autism & Neurodevelopmental Disorders at the University of Missouri. Researchers here cover a broad spectrum of autism spectrum disorders (ASD) interventions, such as behavioral therapies, early detection methods, and pharmacological treatments designed to improve social skills and reduce disruptive behaviors.
Missouri’s focus on neurodevelopmental conditions is unique in that it looks at holistic treatment approaches, including nutritional, cognitive, and social support mechanisms, often involving long-term observational studies that span years to evaluate treatment efficacy.
Cardiovascular diseases
Given Missouri's high prevalence of heart disease, cardiovascular research is a critical area of focus in the state. Institutions like Washington University School of Medicine and Saint Luke's Mid America Heart Institute are heavily involved in clinical trials that seek to prevent and treat heart disease, hypertension, and stroke.
These studies often examine the latest medical devices, such as advanced pacemakers or artificial heart valves, alongside drug treatments aimed at reducing heart failure and stroke risk. Other trials in Missouri focus on prevention strategies, testing the efficacy of lifestyle interventions like weight management and exercise on reducing cardiovascular risk in at-risk populations.
Alzheimer’s disease
The state of Missouri is at the forefront of Alzheimer’s disease research, with institutions like the University of Missouri and Saint Louis University running trials to better understand and treat dementia. Research teams often investigate new drug therapies aimed at slowing cognitive decline, and diagnostic tools that could help detect Alzheimer’s in its early stages.
Additionally, Missouri research centers focus on lifestyle factors, like diet and physical activity, that may influence the progression of Alzheimer's and other forms of dementia, offering innovative non-drug interventions that could benefit those at risk of the disease.
Mental health disorders
Research into mental health disorders is a major focus in Missouri, with trials exploring both pharmaceutical and non-pharmaceutical treatments. Children and adults with ADHD in particular benefit from studies that examine the effectiveness of new medications aimed at improving attention and reducing hyperactivity.
Missouri-based trials also include behavioral therapies that focus on improving executive function, social skills, and academic performance. Beyond ADHD, clinical trials in Missouri frequently address mental health conditions such as depression, anxiety, and bipolar disorder, offering participants access to novel treatments and therapies not yet widely available.
Diabetes and metabolic disorders
Missouri’s clinical trials in diabetes research are robust, particularly in the areas of Type 2 diabetes management and prevention. Many trials involve evaluating the effectiveness of new insulin delivery systems, glucose monitoring technologies, and medications aimed at enhancing insulin sensitivity or lowering blood sugar levels.
With obesity rates also high in Missouri, clinical trials often focus on metabolic disorders and the intersection between obesity, insulin resistance, and cardiovascular health. Trials may explore new dietary interventions, physical activity programs, and medications designed to improve metabolic outcomes.
Infectious diseases
During the COVID-19 pandemic, Missouri played a significant part in treatment and vaccine trials. Leading institutions like Saint Louis University’s Center for Vaccine Development contributed to studies that were crucial in the approval of COVID-19 vaccines and treatments.
Missouri’s involvement in infectious disease research extends beyond COVID-19 trials, including flu vaccine development and trials on newer treatments for diseases like hepatitis and HIV. Ongoing research in infectious diseases also focuses on antibiotic resistance and emerging pathogens, ensuring that the state remains at the cutting edge of global health challenges.
Local regulations and guidelines
Clinical trials in Missouri are governed by a combination of federal, state, and institutional regulations that ensure participant safety and ethical standards. The state follows federal guidelines from agencies like the FDA and HHS, which mandate protections for human subjects, informed consent, and compliance with the Common Rule. All trials must also be approved and monitored by Institutional Review Boards (IRBs) to oversee the ethical conduct of studies.
In addition to federal rules, Missouri’s Department of Health and Senior Services (DHSS) may provide additional oversight for public health-related trials. Clinical trials in the state must also comply with HIPAA regulations to protect participant data and ensure confidentiality. Transparency is required through registration on ClinicalTrials.gov, promoting public trust and scientific rigor. Missouri also emphasizes diversity in patient recruitment to enhance the reliability of research findings across different populations.
Benefits of participating in clinical trials
Participating in a clinical trial provides a unique opportunity for individuals to access cutting-edge treatments and therapies ahead of public availability. This can be especially valuable for those whose conditions have not responded to conventional options. Throughout the trials, participants receive expert medical attention, with dedicated healthcare professionals offering personalized care and close monitoring to ensure safety and efficacy.
Beyond personal benefits, clinical trial participation plays an important role in advancing medical science. These studies often lead to breakthroughs in new treatments and approaches. By taking part, individuals not only gain early access to innovative care but also contribute to critical research efforts, helping to shape the future of healthcare and improve outcomes for others.
Worried about the risks of participating in a clinical trial? Read our comprehensive guide to gain insights into the potential outcomes of participating. Learn about potential risks, benefits, and safety considerations to make an informed decision about your participation in a clinical trial.
How to enroll in a clinical trial in Missouri
Enrolling in a clinical trial through our platform is a straightforward and user-friendly process. Here's how to get started:
- Identify your trial: Use our intuitive search bar or filter options to locate clinical trials specific to requirements. This first step simplifies the process of finding relevant research studies tailored to your needs.
- Select your preferred location: To find trials conveniently located near you, simply input your preferred location into the dedicated filter bar on the left-hand side of the page.
- Explore study details: For in-depth information about each study, simply click the “Learn More” button. This will provide you with comprehensive details about the trial, including objectives, procedures, and eligibility criteria.
- Complete the health profile: After clicking on the “Get started” button you will be taken to our efficient 5-step application process to provide important health information. This helps us match you with the clinical trial that best fits your needs.
- Submit the application: After completing the application, send it in. A clinical trial coordinator will review it and contact you regarding the possibility of participation.