Clinical Trials In Springfield

Discover hundreds of clinical trials in Springfield.
Search clinical trials in Springfield by condition or phase.

e.g. Respiratory Diseases

Springfield•Healthy volunteers: No

Filter results

Results: 173

Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis

Recruiting

Phase 3

Sponsor:

AbbVie

Location:

Springfield, Kansas City, Flagstaff, Glendaleshow 69 more

Code:

NCT05814627

Conditions

Rheumatoid Arthritis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Upadacitinib

Adalimumab

Upadacitinib Matching Placebo

Adalimumab Matching Placebo

MILD® Percutaneous Image-Guided Lumbar Decompression: a Medicare Claims Study

Recruiting

Sponsor:

Vertos Medical, Inc.

Location:

Springfield, West Plains, Washington, Troyshow 940 more

Code:

NCT03072927

Conditions

Lumbar Spinal Stenosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

MILD

Interspinous Process Decompression

Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients

Recruiting

Phase 2

Sponsor:

National Cancer Institute (NCI)

Location:

Springfield, Sunset Hills, Sullivan, Sainte Genevieveshow 94 more

Code:

NCT04310020

Conditions

Recurrent Lung Non-Small Cell Carcinoma

Stage II Lung Cancer AJCC v8

Stage III Lung Cancer AJCC v8

Unresectable Lung Non-Small Cell Carcinoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Atezolizumab

Biospecimen Collection

Computed Tomography

Hypofractionated Radiation Therapy

Magnetic Resonance Imaging

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

Recruiting

Phase 2

Sponsor:

National Cancer Institute (NCI)

Location:

Springfield, Washington, Sunset Hills, Sullivanshow 350 more

Code:

NCT03866382

Conditions

Bladder Adenocarcinoma

Bladder Clear Cell Adenocarcinoma

Bladder Mixed Adenocarcinoma

Bladder Neuroendocrine Carcinoma

Bladder Small Cell Neuroendocrine Carcinoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Bone Scan

Cabozantinib S-malate

Computed Tomography

Ipilimumab

Magnetic Resonance Imaging

Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors

Recruiting

Phase 3

Sponsor:

University of Rochester NCORP Research Base

Location:

Springfield, Washington, Sunset Hills, Sullivanshow 270 more

Code:

NCT03996265

Conditions

Be Diagnosed With Cancer and Have Completed Systemic Therapy

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Bupropion Hydrochloride Controlled-release

Placebo Administration

Quality-of-Life Assessment

Questionnaire Administration

Testing the Addition of an Anti-cancer Drug, Pembrolizumab, to the Usual Intravesical Chemotherapy Treatment (Gemcitabine) for the Treatment of BCG-Unresponsive Non-muscle Invasive Bladder Cancer

Recruiting

Phase 2

Sponsor:

National Cancer Institute (NCI)

Location:

Springfield, Washington, Sunset Hills, Sullivanshow 243 more

Code:

NCT04164082

Conditions

Bladder Urothelial Carcinoma In Situ

Invasive Bladder Mixed Carcinoma

Stage 0a Bladder Cancer AJCC v8

Stage 0is Bladder Cancer AJCC v8

Stage I Bladder Cancer AJCC v8

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Gemcitabine Hydrochloride

Pembrolizumab

Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults

Recruiting

Phase 3

Sponsor:

National Cancer Institute (NCI)

Location:

Springfield, Washington, Saint Peters, Saint Louisshow 138 more

Code:

NCT04530565

Conditions

B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Biospecimen Collection

Blinatumomab

Bone Marrow Aspiration and Biopsy

Cyclophosphamide

Cytarabine

Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment

Recruiting

Phase 3

Sponsor:

Boehringer Ingelheim

Location:

Springfield, Bridgeton, Huntsville, Bullhead Cityshow 9 more

Code:

NCT06151574

Conditions

Lung Cancer, Non-squamous, Non-small Cell

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

zongertinib

pembrolizumab

cisplatin

carboplatin

pemetrexed

A 12-Month Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine

Recruiting

Phase 3

Sponsor:

Eli Lilly and Company

Location:

Springfield, Kansas City, Birmingham, Huntsvilleshow 74 more

Code:

NCT04396574

Conditions

Migraine

Eligibility Criteria

Sex: All

Age: 6 - 17

Healthy Volunteers: Not accepted

Interventions

Lasmiditan

Developing an Internet-Delivered Sexual Health Program for Breast Cancer Survivors, SHINE Trial

Recruiting

Sponsor:

Wake Forest University Health Sciences

Location:

Springfield, Saint Louis, Rolla, Osage Beachshow 185 more

Code:

NCT06216574

Conditions

Breast Cancer Female

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Internet-based Intervention

e.g. Respiratory Diseases

Springfield•Healthy volunteers: No

Filter results

Results: 173

Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis

Recruiting

Phase 3

Sponsor:

AbbVie

Location:

Springfield, Kansas City, Flagstaff, Glendaleshow 69 more

Code:

NCT05814627

Conditions

Rheumatoid Arthritis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Upadacitinib

Adalimumab

Upadacitinib Matching Placebo

Adalimumab Matching Placebo

MILD® Percutaneous Image-Guided Lumbar Decompression: a Medicare Claims Study

Recruiting

Sponsor:

Vertos Medical, Inc.

Location:

Springfield, West Plains, Washington, Troyshow 940 more

Code:

NCT03072927

Conditions

Lumbar Spinal Stenosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

MILD

Interspinous Process Decompression

Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients

Recruiting

Phase 2

Sponsor:

National Cancer Institute (NCI)

Location:

Springfield, Sunset Hills, Sullivan, Sainte Genevieveshow 94 more

Code:

NCT04310020

Conditions

Recurrent Lung Non-Small Cell Carcinoma

Stage II Lung Cancer AJCC v8

Stage III Lung Cancer AJCC v8

Unresectable Lung Non-Small Cell Carcinoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Atezolizumab

Biospecimen Collection

Computed Tomography

Hypofractionated Radiation Therapy

Magnetic Resonance Imaging

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

Recruiting

Phase 2

Sponsor:

National Cancer Institute (NCI)

Location:

Springfield, Washington, Sunset Hills, Sullivanshow 350 more

Code:

NCT03866382

Conditions

Bladder Adenocarcinoma

Bladder Clear Cell Adenocarcinoma

Bladder Mixed Adenocarcinoma

Bladder Neuroendocrine Carcinoma

Bladder Small Cell Neuroendocrine Carcinoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Bone Scan

Cabozantinib S-malate

Computed Tomography

Ipilimumab

Magnetic Resonance Imaging

Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors

Recruiting

Phase 3

Sponsor:

University of Rochester NCORP Research Base

Location:

Springfield, Washington, Sunset Hills, Sullivanshow 270 more

Code:

NCT03996265

Conditions

Be Diagnosed With Cancer and Have Completed Systemic Therapy

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Bupropion Hydrochloride Controlled-release

Placebo Administration

Quality-of-Life Assessment

Questionnaire Administration

Testing the Addition of an Anti-cancer Drug, Pembrolizumab, to the Usual Intravesical Chemotherapy Treatment (Gemcitabine) for the Treatment of BCG-Unresponsive Non-muscle Invasive Bladder Cancer

Recruiting

Phase 2

Sponsor:

National Cancer Institute (NCI)

Location:

Springfield, Washington, Sunset Hills, Sullivanshow 243 more

Code:

NCT04164082

Conditions

Bladder Urothelial Carcinoma In Situ

Invasive Bladder Mixed Carcinoma

Stage 0a Bladder Cancer AJCC v8

Stage 0is Bladder Cancer AJCC v8

Stage I Bladder Cancer AJCC v8

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Gemcitabine Hydrochloride

Pembrolizumab

Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults

Recruiting

Phase 3

Sponsor:

National Cancer Institute (NCI)

Location:

Springfield, Washington, Saint Peters, Saint Louisshow 138 more

Code:

NCT04530565

Conditions

B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Biospecimen Collection

Blinatumomab

Bone Marrow Aspiration and Biopsy

Cyclophosphamide

Cytarabine

Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment

Recruiting

Phase 3

Sponsor:

Boehringer Ingelheim

Location:

Springfield, Bridgeton, Huntsville, Bullhead Cityshow 9 more

Code:

NCT06151574

Conditions

Lung Cancer, Non-squamous, Non-small Cell

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

zongertinib

pembrolizumab

cisplatin

carboplatin

pemetrexed

A 12-Month Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine

Recruiting

Phase 3

Sponsor:

Eli Lilly and Company

Location:

Springfield, Kansas City, Birmingham, Huntsvilleshow 74 more

Code:

NCT04396574

Conditions

Migraine

Eligibility Criteria

Sex: All

Age: 6 - 17

Healthy Volunteers: Not accepted

Interventions

Lasmiditan

Developing an Internet-Delivered Sexual Health Program for Breast Cancer Survivors, SHINE Trial

Recruiting

Sponsor:

Wake Forest University Health Sciences

Location:

Springfield, Saint Louis, Rolla, Osage Beachshow 185 more

Code:

NCT06216574

Conditions

Breast Cancer Female

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Internet-based Intervention