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Postoperative Analgesia Intervention With Non-opioid Alternatives (PAIN-Alt) Trial - Breast Surgery

for
Post Operative Pain, Opioid Analgesic Adverse Reaction, Surgery,
Location: Montreal
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

Sex: All

Age: 18+

Code: NCT06507345

Recruiting

Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma

for
Recurrent Diffuse Large B-Cell Lymphoma,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT05800405

Early_phase1, Recruiting

Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib Binimetinib in Melanoma

for
Melanoma Stage III, Melanoma Stage IV, BRAF V600 Mutation
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT04741997

Early_phase1, Recruiting

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for
Metastatic Clear Cell Renal Cell Carcinoma,
Location: Saint Johnsbury VT, Lebanon NH, Lake Success NY,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT04510597

Phase3, Recruiting

Hyperfractionated Dual Equivalent Fractionated Radiation Therapy

for
Diffuse Large B-Cell Lymphoma
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 18+

Code: NCT06898905

Recruiting

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Cemiplimab Before and After Surgery for the Treatment of High Risk Cutaneous Squamous Cell Cancer

for
Metastatic Skin Squamous Cell Carcinoma,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT04428671

Phase1, Recruiting

CD123-Directed T-Cell Therapy for Acute Myelogenous Leukemia (CATCHAML)

for
AML/MDS, B-ALL, T-ALL, BPDCN
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 21

Code: NCT04318678

Phase1, Recruiting

A Study to Learn About How Changing Therapy From Emicizumab to Marstacimab Affects People With the Severe Hemophilia A.

for
Severe Hemophilia A
Location: Greenville NC, Los Angeles CA
Sponsor: Pfizer

Sex: Male

Age: 12 - 70+

Code: NCT06703606

Phase1, Recruiting

Phase II Study of Salvage Radiation Treatment After B-cell Maturation Antigen Chimeric Antigen Receptor T-cell Therapy for Relapsed Refractory Multiple Myeloma

for
Multiple Myeloma, Plasma Cell Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05336383

Phase2, Recruiting

A Study of Axicabtagene Ciloleucel and Glofitamab as Second-Line Therapy for Relapsed or Refractory Patients With Large B Cell Lymphoma

for
B Cell Lymphoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06213311

Phase2, Recruiting

Ceftriaxone Pulse Dose for Post-Treatment Lyme Disease

for
Post-Treatment Lyme Disease
Location: East Syracuse NY
Sponsor: State University of New York - Upstate Medical University

Sex: All

Age: 18 - 70+

Code: NCT06611111

Early_phase1, Recruiting

Flexible Insulin Therapy Untethered Insulin Regimen in Avidly Exercising Patients With Type 1 Diabetes: FIT Untethered

for
Type 1 Diabetes Mellitus
Location: Toronto
Sponsor: LMC Diabetes & Endocrinology Ltd.

Sex: All

Age: 18 - 55

Code: NCT03838783

Recruiting

Mitigating the Pro-inflammatory Phenotype of Obesity

for
Blood Pressure, Diabetes, Obesity, Insulin Resistance,
Location: Kansas City KS
Sponsor: University of Kansas Medical Center

Sex: All

Age: 18 - 70+

Code: NCT04934228

Phase1, Recruiting

OurSleepKit To Support CPAP Adherence

for
Obstructive Sleep Apnea, CPAP Treatment, Treatment Adherence
Location: Pittsburgh PA
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All

Age: 18+

Code: NCT06621511

Recruiting

Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma

for
Oropharyngeal Squamous Cell Carcinoma
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT04852328

Phase2, Recruiting

T-Cell Therapy (EB103) in Adults With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (NHL)

for
B-Cell Non-Hodgkin's Lymphoma (NHL), Lymphoma, Non-Hodgkins,
Location: Dallas TX, Sacramento CA
Sponsor: Estrella Biopharma, Inc.

Sex: All

Age: 18+

Code: NCT06343311

Phase1, Phase2, Recruiting

Fludarabine and Cyclophosphamide With or Without Rituximab Before CD19 Chimeric Antigen Receptor T Cells for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma

for
Recurrent Diffuse Large B-Cell Lymphoma,
Location: Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT05052528

Phase1, Recruiting

Adaptive Therapy of Vismodegib in Advanced Basal Cell Carcinoma

for
Advanced Basal Cell Carcinoma
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT05651828

Early_phase1, Recruiting

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

for
Plasma Cell Myeloma, RISS Stage I Plasma Cell Myeloma,
Location: Boston MA, Stoneham MA, Westerly RI, Waterford CT,
Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All

Age: 18+

Code: NCT04566328

Phase3, Recruiting

Prevalence of Humoral Dysfunction in Pts With Frequent Exacerbations of COPD, and the Effect of SCIgR for Prevention

for
COPD Exacerbation Acute
Location: Rochester NY
Sponsor: Rochester General Hospital

Sex: All

Age: 18 - 70+

Code: NCT05764993

Phase2, Recruiting