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Active & Responsive

PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis

for
Coronary Artery Disease Risk Factors Multiple,
Location: New York NY, Durham NC, Hiram GA, Birmingham AL,
Sponsor: Duke University

Sex: All

Age: 30 - 60

Code: NCT07232069

Phase3, Recruiting
Active & Responsive

Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

for
Chronic Pain, Acute Pain, Post Operative Pain,
Location: Providence RI
Sponsor: Brown University

Sex: All

Age: 18+

Code: NCT05754190

Recruiting
Active & ResponsiveNew

Success Rates and Safety of Steroid Injections in Managing Spinal and Sacro-Iliac Pain (CORTisone Injection Spine Study)

for
Back Pain Lower Back, Neck Pain, Radiculopathy Multiple Sites,
Location: Thornhill
Sponsor: Igor Wilderman. MD

Sex: All

Age: 18+

Code: NCT07762170

Recruiting
Active & Responsive

RASopathy Biorepository

for
RAS Mutation, Neurofibromatosis 1, Noonan Syndrome,
Location: Cincinnati OH
Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All

Age: 0+

Code: NCT04395495

Recruiting
Active & Responsive

Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of Parathyroid Tumors

for
Primary Hyperparathyroidism, Parathyroid Cancer,
Location: Bethesda MD
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All

Age: 18 - 70+

Code: NCT07444723

Phase2, Phase3, Recruiting

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Active & Responsive

Comprehensive Assessment of Neurodegeneration and Dementia

for
Dementia, Mild Cognitive Impairment (MCI),
Location: Halifax, Quebec, Montreal, Toronto, Hamilton, London,
Sponsor: McGill University

Sex: All

Age: 50 - 70+

Code: NCT03402919

Recruiting
Active & Responsive

UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells

for
Adrenoleukodystrophy, Batten Disease, Mucopolysaccharidosis II,
Location: Durham NC
Sponsor: Joanne Kurtzberg, MD

Sex: All

Age: 0 - 22

Code: NCT02254863

Phase1, Recruiting
Active & Responsive

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

for
Diffuse Midline Glioma (DMG), Glioblastoma,
Location: Philadelphia PA, Washington D.C. DC, Atlanta GA,
Sponsor: Sabine Mueller, MD, PhD

Sex: All

Age: 2 - 21

Code: NCT04732065

Phase1, Recruiting
Active & Responsive

Nebulized Ketamine for the Treatment of Major Depressive Disorder

for
Severe Depression, Moderate Depression, Ketamine, Midazolam,
Location: Brooklyn NY
Sponsor: Theresa Jacob, PhD, MPH

Sex: All

Age: 18 - 70+

Code: NCT06752759

Phase3, Recruiting
Active & Responsive

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

for
Cancer, Metastatic, Cancer, Cancer of Pancreas, Cancer of Liver,
Location: Scarborough ME, Worcester MA, Hartford CT, Norwalk CT,
Sponsor: Massive Bio, Inc.

Sex: All

Age: 0+

Code: NCT03452774

Recruiting
Active & Responsive

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

for
Breast Neoplasms, Brain Neoplasms, Neoplasms by Site, Neoplasms,
Location: Boston MA, Norfolk VA, Detroit MI, Centerville OH,
Sponsor: Stemline Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05386108

Phase1, Phase2, Recruiting
Active & Responsive

A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell Sarcoma

for
HLA-A*0201 Positive Cells Present, Clear Cell Sarcoma (CCS)
Location: New York NY, Los Angeles CA
Sponsor: Sarcoma Alliance for Research through Collaboration

Sex: All

Age: 18+

Code: NCT06942442

Phase2, Recruiting
New

Exploring the Utility of [18F]3F4AP for Demyelination Imaging

for
Demyelinating Disorders, MCI, Alzheimer's Disease (AD),
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 18 - 70+

Code: NCT06999434

Phase1, Recruiting
New

Brain Imaging and Immune Changes During Remibrutinib Treatment in Multiple Sclerosis.

for
Multiple Sclerosis (MS) - Relapsing-remitting
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 40 - 70

Code: NCT07758270

Recruiting
New

A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy

for
Multiple Sclerosis
Location: Atlanta GA, Cordova TN
Sponsor: Genentech, Inc.

Sex: All

Age: 18 - 65

Code: NCT07609719

Recruiting
New

Music-4-MS to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study

for
Multiple Sclerosis, Pathologic Processes,
Location: Austin TX
Sponsor: University of Texas at Austin

Sex: All

Age: 18 - 70+

Code: NCT07759115

Recruiting
New

Electrical Stimulation Exercise for Individuals With Lower Limb Paralysis

for
Spinal Cord Injury/Disorder, Stroke, Multiple Sclerosis,
Location: Cleveland OH
Sponsor: Louis Stokes VA Medical Center

Sex: All

Age: 18+

Code: NCT07768761

Recruiting

PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases

for
Multiple Sclerosis, Alzheimer's Disease
Location: Boston MA
Sponsor: Brigham and Women's Hospital

Sex: All

Age: 18 - 70+

Code: NCT02649985

Phase1, Phase2, Recruiting

A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis

for
Multiple Sclerosis
Location: East Hanover NJ
Sponsor: Kessler Foundation

Sex: All

Age: 18 - 70

Code: NCT06197685

Recruiting

Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis

for
Multiple Sclerosis, Relapsing-Remitting
Location: Tampa FL, Louisville KY, Chicago IL, Milwaukee WI,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 10 - 17

Code: NCT06408259

Phase3, Recruiting