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Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

for
Brain Cancer, Glioblastoma, Metastatic Cancer,
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06058988

Phase2, Recruiting

Neoepitope-based Personalized DNA Vaccine Approach in Pediatric Patients With Recurrent Central Nervous System Tumors

for
Pediatric Recurrent Central Nervous System Tumors
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 0 - 25

Code: NCT03988283

Phase1, Recruiting

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

for
Advanced Solid Tumor, Advanced Breast Cancer,
Location: Durham NC, Columbus OH, Nashville TN, Denver CO,
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT06120283

Phase1, Recruiting

PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recovery

for
Malignant Female Reproductive System Neoplasm,
Location: Boston MA, San Francisco CA
Sponsor: University of California, San Francisco

Sex: Female

Age: 18+

Code: NCT06089083

Recruiting

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

for
Cardiotoxicity, HER2/Neu Positive,
Location: Winchester MA, Burlington MA, White Plains NY, Nyack NY,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT03418961

Phase3, Recruiting

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Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers

for
Stage IV Esophageal Adenocarcinoma,
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT04221893

Recruiting

Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma

for
Glioblastoma, Brain Cancer, Brain Neoplasm, Brain Tumor,
Location: New York NY
Sponsor: Northwell Health

Sex: All

Age: 18+

Code: NCT02861898

Phase1, Phase2, Recruiting

Norris ORIEN Total Cancer Care

for
Cancer Risk, Malignant Neoplasm
Location: Los Angeles CA
Sponsor: University of Southern California

Sex: All

Age: 18+

Code: NCT02970045

Recruiting

Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Charlottesville VA, Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: Female

Age: 18+

Code: NCT04348747

Phase2, Recruiting

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

for
Neoplasms, Brain, Glioblastoma Multiforme,
Location: Birmingham AL, St Louis MO, Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 3 - 22

Code: NCT03911388

Phase1, Recruiting

Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy

for
Pediatric Disorder, Genetic Predisposition, Dystonia, Secondary,
Location: Kansas City MO
Sponsor: Children's Mercy Hospital Kansas City

Sex: All

Age: 5 - 17

Code: NCT06554288

Phase1, Recruiting

Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pancreatic Cancer and Peritoneal Metastasis

for
Metastatic Pancreatic Carcinoma,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 70+

Code: NCT04858009

Phase2, Recruiting

Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors

for
Advanced Malignant Solid Neoplasm,
Location: New Haven CT, Gainesville FL, Oklahoma City OK
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05053971

Phase1, Phase2, Recruiting

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

for
Advanced Esophageal Squamous Cell Carcinoma,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06265285

Phase2, Recruiting

Esophageal Cancer Risk Registry

for
Esophageal Cancer, Gastroesophageal Reflux Disease (GERD),
Location: Pittsburgh PA
Sponsor: University of Pittsburgh

Sex: All

Age: 18+

Code: NCT00260585

Recruiting

A Clinical Trial to Assess COM503 in Participants With Advanced Solid Malignancies

for
Neoplasm, Cancer, Malignant Tumors
Location: Boston MA, New Haven CT, Fairfax VA, Grand Rapids MI,
Sponsor: Compugen Ltd

Sex: All

Age: 18+

Code: NCT06759649

Phase1, Recruiting

Cryoablation vs Lumpectomy in T1 Breast Cancers

for
Breast Cancer, Breast Neoplasm
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: Female

Age: 50+

Code: NCT05505643

Recruiting

Sacituzumab Govitecan in Combination With Cisplatin in Platinum Sensitive Recurrent Ovarian and Endometrial Cancer

for
Ovarian Cancer, Malignant Neoplasm of Uterus
Location: New York NY
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: Female

Age: 18+

Code: NCT06040970

Phase1, Phase2, Recruiting

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

for
Advanced Solid Tumor, Advanced Malignant Neoplasm,
Location: Boston MA, New Haven CT, New York NY, Philadelphia PA,
Sponsor: PMV Pharmaceuticals, Inc

Sex: All

Age: 12+

Code: NCT04585750

Phase1, Phase2, Recruiting

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

for
Breast Cancer, Metastatic Breast Cancer, Breast Neoplasm,
Location: Riverhead NY, Patchogue NY, Port Jefferson Station NY,
Sponsor: BriaCell Therapeutics Corporation

Sex: All

Age: 18+

Code: NCT06072612

Phase3, Recruiting