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A Novel Molecular Approach to Blood DNA Screening for Cancer: Specificity Assessment (The NOMAD Study)

for
Hematopoietic and Lymphoid System Neoplasm,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06192875

Recruiting

Validation of DNA Methylation Markers for Universal and Site-specific Guided Cancer Detection, VANGUARD Study

for
Hematopoietic and Lymphatic System Neoplasm,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06304168

Recruiting

A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue Sarcomas

for
Soft Tissue Sarcomas
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 1 - 30

Code: NCT07444619

Phase1, Recruiting

Remdesivir for the Treatment of Upper Respiratory Tract Infection Due to RSV in Immunocompromised Individuals

for
Hematopoietic and Lymphatic System Neoplasm, Autoimmune Disease,
Location: Houston TX, Seattle WA, Duarte CA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT06817889

Phase2, Recruiting

A Phase 2 Study to Evaluate Efficacy of Calaspargase Pegol-mknl and Decitabine Combined With Venetoclax in Pediatric, Adolescent, and Young Adult Patients With Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia (T-ALL) and T- Cell Lymphoblastic Lymphoma (T-LLy)

for
T-cell Acute Lymphoblastic Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 0 - 21

Code: NCT06561074

Phase2, Recruiting

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A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

for
Malignant Neoplasm
Location: Boston MA, Valhalla NY, New York NY, New Brunswick NJ,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 0 - 17

Code: NCT07630974

Phase1, Phase2, Recruiting

Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor

for
Desmoplastic Small Round Cell Tumor, Osteosarcoma,
Location: Boston MA, New York NY, Philadelphia PA, Baltimore MD,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 12 - 39

Code: NCT04616560

Phase2, Recruiting

Clinical Study of MK-4884 in Participants With Advanced or Metastatic Solid Tumors (MK-4884-001)

for
Malignant Neoplasm
Location: Montreal, San Antonio TX
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07600749

Phase1, Recruiting

A Clinical Study of MK-8294 in Participants With Advanced Solid Tumors (MK-8294-001)

for
Metastatic Neoplasm
Location: Hackensack NJ, Chicago IL, Houston TX
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07030712

Phase1, Recruiting

Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer

for
Pancreatic Carcinoma,
Location: Columbus OH
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT03711890

Recruiting

Improved Successful Retrieval Rate of HydroMARK Plus Breast Biopsy Site Marker in Comparison to HydroMARK as Well as Improved Surgeon Satisfaction

for
Breast Neoplasm
Location: Birmingham AL
Sponsor: University of Alabama at Birmingham

Sex: Female

Age: 18 - 70+

Code: NCT06294574

Recruiting

Impact of Project ECHO on Improving the Quality of Palliative Care in Patients With Advanced Cancer and Their Caregivers in Underserved Areas of Kenya, Nigeria, Ghana, South Africa, India, and Ethiopia

for
Advanced Malignant Solid Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 0+

Code: NCT04984551

Phase2, Recruiting

Different Types of Massage Therapy to Reduce Anxiety During Chemotherapy Infusion in Patients With Cancer

for
Hematopoietic and Lymphatic System Neoplasm,
Location: Irvine CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07184294

Recruiting

Study of How Safe and Effective Tarlatamab is in Brain Cancers

for
Astrocytic Tumor, Oligodendroglial Tumor
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT06776250

Phase2, Recruiting

Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy

for
Malignant Digestive System Neoplasm
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT07456852

Phase1, Phase2, Recruiting

Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy

for
GBM, Glioblastoma Multiforme (GBM),
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18 - 70+

Code: NCT07179328

Phase1, Recruiting

Educational Tools for the Improvement of Early Advance Care Planning in Adolescents and Young Adults With Advanced Solid Tumors and High-Grade Brain Tumors

for
Advanced Malignant Solid Neoplasm, Malignant Brain Neoplasm,
Location: Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 39

Code: NCT07174661

Recruiting

Exploring the Effect of Calaspargase Pegol on the Coagulation System in Pediatric Acute Lymphoblastic Leukemia (ALL) Patients: Pilot Study

for
Childhood Acute Lymphoblastic Leukemia,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 2 - 22

Code: NCT07071051

Recruiting

Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment

for
Hematopoietic and Lymphatic System Neoplasm,
Location: Charleston SC, Augusta GA, Greenville SC, Anderson SC,
Sponsor: NRG Oncology

Sex: All

Age: 18+

Code: NCT06279013

Recruiting

An Individualized Online Home-Based Exercise Program for Improving Symptoms in Gynecologic Cancer Survivors

for
Malignant Female Reproductive System Neoplasm
Location: Decatur GA, Atlanta GA
Sponsor: Emory University

Sex: Female

Age: 18+

Code: NCT06709534

Recruiting