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Active & Responsive

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

for
Triple Negative Breast Neoplasms
Location: Quebec, Chicoutimi, Mineola NY, New York NY,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06841354

Phase3, Recruiting
Active & Responsive

Opioids, Low Nicotine Cigarettes, and Chronic Pain

for
Chronic Pain, Tobacco Use, Opioid Substitution Treatment
Location: Durham NC
Sponsor: Duke University

Sex: All

Age: 21+

Code: NCT06747871

Recruiting
Active & Responsive

Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty

for
Knee Osteoarthritis, Knee Arthropathy
Location: Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 21 - 70+

Code: NCT06617871

Recruiting
Active & Responsive

Dopaminergic Therapy for Anhedonia - 2

for
Anhedonia, Depression
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 25 - 55

Code: NCT06075771

Recruiting
Active & Responsive

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

for
Platinum-resistant Ovarian Cancer,
Location: Stony Brook NY, Greenville NC, Silver Spring MD,
Sponsor: Genelux Corporation

Sex: Female

Age: 18+

Code: NCT05281471

Phase3, Recruiting

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Active & Responsive

Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)

for
Bipolar Disorder
Location: Houston TX
Sponsor: Joao L. DeQuevedo

Sex: All

Age: 22 - 70+

Code: NCT04080778

Recruiting
Active & Responsive

Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)

for
Treatment Resistant Depression
Location: Toronto
Sponsor: Centre for Addiction and Mental Health

Sex: All

Age: 18 - 65

Code: NCT06512220

Phase2, Recruiting
Active & Responsive

Training Reward Responsiveness Through Virtual Reality

for
Positive Affect, Depression
Location: Los Angeles CA
Sponsor: University of California, Los Angeles

Sex: All

Age: 18+

Code: NCT07219875

Phase2, Recruiting
Active & Responsive

A Translational Understanding of Obesity-Related Phenotypes Using Brain Imaging and Manipulation

for
Obesity
Location: Philadelphia PA
Sponsor: Drexel University

Sex: All

Age: 18 - 35

Code: NCT06353464

Recruiting
Active & Responsive

Observing Metabolism of EPA With Consideration of Genetics And Sex

for
Healthy, Omega 3, Metabolism, Lipids
Location: Toronto
Sponsor: University of Toronto

Sex: All

Age: 18 - 35

Code: NCT06975241

Recruiting
Active & Responsive

Listening to Calming Music

for
Music, Autonomic State
Location: Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 18 - 70+

Code: NCT06710886

Recruiting
Active & Responsive

Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms

for
Normal Physiology
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18 - 70+

Code: NCT05829044

Recruiting
Active & Responsive

Feasibility of Identifying Brain Mechanisms of Qigong and Behavioral Outcomes After Qigong Practice in People With Chronic Low Back Pain

for
Low Back Pain
Location: Minneapolis MN
Sponsor: University of Minnesota

Sex: All

Age: 18 - 70

Code: NCT04164225

Recruiting
Active & Responsive

Perceptual Influences From Smoking Cannabis: an Experimental Study

for
Cannabis Use, Stress
Location: Boulder CO
Sponsor: University of Colorado, Boulder

Sex: All

Age: 21 - 65

Code: NCT06588582

Recruiting
Active & Responsive

BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies

for
Healthy
Location: Halifax, Boston MA, Quebec, Garden City NY, Mineola NY,
Sponsor: Pfizer

Sex: All

Age: 0 - 49

Code: NCT07160244

Phase3, Recruiting
Active & Responsive

A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

for
Bipolar Disorder Type I With Mania
Location: New Haven CT, Staten Island NY, Marlton NJ,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18 - 65

Code: NCT06929273

Phase3, Recruiting
Active & Responsive

MRI Guided Closed-loop TMS-EEG

for
Normal Physiology, Amnestic Mild Cognitive Impairment
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18 - 70+

Code: NCT06050603

Recruiting
Active & Responsive

Dyadic Financial Incentive Treatments for Dual Smoker Couples

for
Smoking, Cigarette
Location: Tulsa OK
Sponsor: University of Oklahoma

Sex: All

Age: 18+

Code: NCT06296849

Phase2, Recruiting
Active & Responsive

A Study to Learn More About the Safety of BIIB145 and How it is Processed in the Body of Healthy Adult Participants

for
Healthy Volunteer
Location: Austin TX
Sponsor: Biogen

Sex: All

Age: 18 - 55

Code: NCT07225517

Phase1, Recruiting
Active & Responsive

Cervical Plexus Hydrodissection With D5W Versus NS for Treatment-Resistant PTSD

for
PTSD
Location: Lexington KY, Madison WI, Portland OR
Sponsor: Dr. Dean Reeves Clinic

Sex: All

Age: 19 - 70+

Code: NCT07382596

Recruiting