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Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)
Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults
What dental clinical trials are studying
Dental implants. New implant designs and surfaces, and materials that rebuild bone where a tooth has been missing for a while, so an implant can be placed. Implant studies usually follow participants for years, because the question is how long the implant lasts.
Orthodontics. Clear aligner systems tested in adults with crowded or misaligned teeth, comparing how well and how fast they move teeth.
Fillings and restorations. Newer composite materials tested for wear, color, and how well they hold up in front teeth over time.
Gum disease and oral health. Treatments for periodontal disease, and programs that bring dental screening into regular medical visits for older adults and people with chronic conditions such as diabetes.
Dental fear. Stepped care programs that start with simple coping strategies and add more support only if needed, for teenagers and adults who avoid the dentist because of fear.
Children's cavities. Studies of silver diamine fluoride, a liquid that stops decay without drilling, and of sealants.
Do dental trials cover the cost of treatment?
This is the most common question, so here is the honest answer. In a dental clinical trial, the study procedure being tested, for example the implant or the aligners, and the study visits and follow up are typically provided by the research at no cost to you. Routine care outside the study is not, and a trial cannot promise which group you will be in when two approaches are compared. It is not "free dental work," but for the specific treatment being studied it can remove the cost barrier that keeps many people from care.
Exactly what is covered is written in the consent form before you decide. Our guide to what clinical trials cost explains the general rules.
Who can participate in dental clinical trials?
It depends on the study. Implant trials enroll adults missing one or more teeth, usually with enough jawbone or a plan to rebuild it, and may exclude heavy smokers and people with uncontrolled diabetes, because both affect healing. Aligner trials want adults with mild to moderate crowding and no active gum disease. Filling studies enroll people who need a specific type of restoration. Dental fear studies enroll people 13 and older who avoid care, and oral health programs enroll older adults through their regular clinic. Eligibility always varies by study.
Can I get dental implants through a clinical trial?
Implant trials do place implants in participants who qualify, and the study implant and visits are typically provided by the research. You must meet the study's rules, such as having enough jawbone, and long follow up is required.
Do dental trial participants get paid?
Some studies offer compensation for time and travel, and study related procedures and visits are typically provided at no cost to participants. Compensation varies by trial and is always described during the informed consent process before you agree to anything.
Curious whether clinical trials pay participants? Here's how compensation actually works.
How to enroll in a dental clinical trial
Find your trial. Use the filters. Titles usually name the treatment: "implant," "aligner," "composite," "periodontal," or "dental fear."
Choose a location. Enter your city or state. Most dental studies run at one dental school or clinic and need several visits, so check the site address.
Read the study details. Click "Learn More" for the age range, the dental condition required, and how long follow up lasts, which for implants can be years.
Complete the health profile. Click "Get started" to begin the 5-step application. Have three things ready: what dental problem you have and any recent x rays or a dentist's diagnosis, whether you smoke and any chronic conditions such as diabetes, and the dental work you have already had.
Submit the application. A clinical trial coordinator reviews it and contacts you. Nothing is decided until you have gone through informed consent, and participation is voluntary at every step.