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ALS Clinical Trials

Browse 127 ALS clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia

for
Anarthria, Dysarthria, Tetraplegia, Spinal Cord Injuries,
Location: Boston MA, Stanford CA
Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All

Age: 18 - 70+

Code: NCT05724173

Recruiting

Evaluating Verbal Communication in Structured Interactions: Theoretical and Clinical Implications

for
Amyotrophic Lateral Sclerosis
Location: University Park PA
Sponsor: Penn State University

Sex: All

Age: 18 - 70+

Code: NCT06266403

Recruiting

A Substudy of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis

for
Amyotrophic Lateral Sclerosis
Location: Montreal, Toronto
Sponsor: Eli Lilly and Company

Sex: All

Age: 18 - 70+

Code: NCT07571174

Phase1, Recruiting

A Master Protocol (OLMP): A Study of LY4256984 in Participants With Amyotrophic Lateral Sclerosis (ALS)

for
Amyotrophic Lateral Sclerosis
Location: Montreal, Toronto
Sponsor: Eli Lilly and Company

Sex: All

Age: 18 - 70+

Code: NCT07571200

Phase1, Recruiting

A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS)

for
Amyotrophic Lateral Sclerosis
Location: Boston MA
Sponsor: Biogen

Sex: All

Age: 18+

Code: NCT07259980

Recruiting

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Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease

for
Neuromuscular Diseases (NMD), Amyotrophic Lateral Sclerosis,
Location: Columbia MO
Sponsor: University of Missouri-Columbia

Sex: All

Age: 18+

Code: NCT07478172

Recruiting

Assessing Perceptual Effects of Interactive Tasks

for
Amyotrophic Lateral Sclerosis
Location: University Park PA
Sponsor: Penn State University

Sex: All

Age: 18 - 65

Code: NCT06828523

Recruiting

Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

for
Amyotrophic Lateral Sclerosis, Neuromuscular Disease, Stroke,
Location: Boston MA, Ann Arbor MI, Sacramento CA
Sponsor: Paradromics

Sex: All

Age: 22 - 70+

Code: NCT07357428

Recruiting

Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

for
Amyotrophic Lateral Sclerosis
Location: Boston MA, Philadelphia PA, Jacksonville FL,
Sponsor: Vector Y Therapeutics

Sex: All

Age: 18+

Code: NCT07287397

Phase1, Phase2, Recruiting

VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration

for
Tetraplegia/Tetraparesis, Quadriplegia,
Location: Dallas TX
Sponsor: Neuralink Corp

Sex: All

Age: 22 - 70+

Code: NCT07224256

Recruiting

Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis

for
Amyotrophic Lateral Sclerosis,
Location: Iowa City IA
Sponsor: University of Iowa

Sex: All

Age: 18 - 70+

Code: NCT07224269

Early_phase1, Recruiting

Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing

for
Amyotrophic Lateral Sclerosis Type 4,
Location: Bethesda MD
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All

Age: 5 - 70+

Code: NCT04394871

Recruiting

Chromatic Pupillometry to Assess the Melanopsin-Light Pathway in Progressive Supranuclear Palsy

for
PSP - Progressive Supranuclear Palsy, PD - Parkinson's Disease,
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 55+

Code: NCT03330353

Recruiting

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)

for
Anarthria, Dysarthria, Tetraplegia, Spinal Cord Injuries,
Location: Sacramento CA
Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All

Age: 18 - 70+

Code: NCT06094205

Recruiting

PREVENT ALL ALS Study

for
Amyotrophic Lateral Sclerosis
Location: Boston MA, New Britain CT, Lebanon NH, New York NY,
Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All

Age: 18+

Code: NCT06581861

Recruiting

Quantitative and Repetitive TMS in ALS - Recruiting for Stage 2

for
Amyotrophic Lateral Sclerosis
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18+

Code: NCT05983211

Recruiting

The Myelin Disorders Biorepository Project

for
Leukodystrophy, White Matter Disease, Leukoencephalopathies,
Location: Boston MA, Philadelphia PA, Baltimore MD,
Sponsor: Children's Hospital of Philadelphia

Sex: All

Age: 0+

Code: NCT03047369

Recruiting

Retinoblastoma Phase II Expanded Access Clinical Trial

for
Retinoblastoma
Location: New York NY, Milwaukee WI
Sponsor: Targeted Therapy Technologies, LLC

Sex: All

Age: 0 - 8

Code: NCT06679634

Phase2, Recruiting

ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia

for
Beta-Thalassemia
Location: Philadelphia PA
Sponsor: Children's Hospital of Philadelphia

Sex: All

Age: 18 - 40

Code: NCT06364774

Phase1, Phase2, Recruiting

A Trial to Evaluate Safety, Tolerability, and Preliminary Efficacy of Misetionamide (GP-2250) as Monotherapy or in Combination With Gemcitabine

for
Ovarian Cancer
Location: Boston MA, Phildelphia PA, Chicago IL, Fairway KS
Sponsor: Persevere Therapeutics Inc.

Sex: Female

Age: 18+

Code: NCT03854110

Phase1, Recruiting

What are ALS clinical trials?

Amyotrophic Lateral Sclerosis (ALS) clinical trials are research studies conducted to explore and evaluate new treatments, therapies, and diagnostic tools for ALS, commonly known as Lou Gehrig’s disease. These trials are crucial in the search for effective ways to slow the progression of the disease, manage symptoms, and ultimately find a cure for ALS.

The importance of clinical trials in ALS research

Clinical trials are essential in ALS research as they are the primary method for testing new treatments and interventions. They help in understanding the effectiveness and safety of these treatments in humans. Through these trials, researchers can uncover new insights into the disease, leading to improved care, symptom management, and potentially life-extending therapies for those affected by ALS.

Types of ALS clinical trials

Innovations in ALS treatment through clinical trials

Who can participate in ALS clinical trials?

How to enroll in an ALS clinical trial