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ALS Clinical Trials

Browse 127 ALS clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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The National Amyotrophic Lateral Sclerosis Registry

for
Amyotrophic Lateral Sclerosis
Location: Atlanta GA
Sponsor: Centers for Disease Control and Prevention

Sex: All

Age: 18+

Code: NCT01772602

Recruiting

Accurate Test of Limb Isometric Strength (ATLIS) in ALS

for
Amyotrophic Lateral Sclerosis
Location: Los Angeles CA
Sponsor: Cedars-Sinai Medical Center

Sex: All

Age: 18+

Code: NCT02374606

Recruiting

Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula Intolerance in pALS

for
Amyotrophic Lateral Sclerosis, Gastrointestinal Intolerance,
Location: Fort Lauderdale FL
Sponsor: Andrea Charvet

Sex: All

Age: 18+

Code: NCT06609213

Recruiting

Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers

for
Amyotrophic Lateral Sclerosis (ALS), Parkinson Disease (PD),
Location: Jacksonville FL, Stanford CA, San Francisco CA
Sponsor: Ashvattha Therapeutics, Inc.

Sex: All

Age: 18 - 70+

Code: NCT05395624

Phase1, Phase2, Recruiting

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

for
Tetraplegia, Spinal Cord Injuries,
Location: Boston MA, Providence RI, Atlanta GA, Houston TX,
Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All

Age: 18 - 70+

Code: NCT00912041

Recruiting

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Augmented Reality BCI Longitudinal Study for Persons With Late Stage ALS

for
ALS (Amyotrophic Lateral Sclerosis)
Location: Santa Barbara CA
Sponsor: Cognixion

Sex: All

Age: 18+

Code: NCT06810219

Recruiting

Investigation on the Cortical Communication (CortiCom) System

for
Tetraplegia, Locked-in Syndrome, Brainstem Stroke,
Location: Baltimore MD
Sponsor: Johns Hopkins University

Sex: All

Age: 22 - 70

Code: NCT03567213

Recruiting

Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS

for
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis,
Location: Quebec, Montreal, Toronto, Edmonton
Sponsor: University of Alberta

Sex: All

Age: 18+

Code: NCT05204017

Recruiting

Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders

for
Amyotrophic Lateral Sclerosis
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05474235

Recruiting

CC100: Phase 1 Multiple-Dose Safety and Tolerability in Subjects With ALS

for
Amyotrophic Lateral Sclerosis
Location: Indianapolis IN
Sponsor: Chemigen, LLC

Sex: All

Age: 18 - 64

Code: NCT03049046

Phase1, Recruiting

Precise Robotically IMplanted Brain-Computer InterfacE

for
Tetraplegia/Tetraparesis, Quadriplegia,
Location: Miami FL, Phoenix AZ
Sponsor: Neuralink Corp

Sex: All

Age: 22 - 70+

Code: NCT06429735

Recruiting

Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone

for
Amyotrophic Lateral Sclerosis
Location: Loma Linda CA
Sponsor: Loma Linda University

Sex: All

Age: 18 - 70+

Code: NCT04097158

Recruiting

RAPA-501 Therapy for ALS

for
Amyotrophic Lateral Sclerosis
Location: Boston MA
Sponsor: Rapa Therapeutics LLC

Sex: All

Age: 18+

Code: NCT04220190

Phase2, Phase3, Recruiting

Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis

for
Amyotrophic Lateral Sclerosis
Location: Baltimore MD
Sponsor: Johns Hopkins University

Sex: All

Age: 18+

Code: NCT06656702

Early_phase1, Recruiting

CAN-PRIME: Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices

for
Tetraplegia/Tetraparesis, Quadriplegia,
Location: Toronto
Sponsor: Neuralink Corp

Sex: All

Age: 19+

Code: NCT06700304

Recruiting

Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

for
Amyotrophic Lateral Sclerosis
Location: Burlington MA, Baltimore MD, Charlottesville VA,
Sponsor: AB Science

Sex: All

Age: 18 - 70+

Code: NCT03127267

Phase3, Recruiting

A Study to Assess the Safety, Tolerability, and Pharmacology of Darifenacin in Patients With ALS

for
Amyotrophic Lateral Sclerosis
Location: Montreal, Ottawa
Sponsor: Oliver Blanchard

Sex: All

Age: 18 - 70+

Code: NCT06249867

Phase2, Recruiting

NeuroCognitive Communicator: Safety Study

for
Motor Neuron Disease, Amyotrophic Lateral Sclerosis,
Location: Ottawa
Sponsor: Ottawa Hospital Research Institute

Sex: All

Age: 18 - 70

Code: NCT03100110

Recruiting

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

for
Frontotemporal Dementia, Amyotrophic Lateral Sclerosis,
Location: Bethesda MD
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All

Age: 18 - 70+

Code: NCT03225144

Recruiting

A Study of Ranolazine in ALS

for
Amyotrophic Lateral Sclerosis
Location: Jacksonville FL, Columbus OH, Columbia MO, Fairway KS,
Sponsor: Swathy Chandrashekhar, MBBS

Sex: All

Age: 18+

Code: NCT06527222

Phase2, Recruiting

What are ALS clinical trials?

Amyotrophic Lateral Sclerosis (ALS) clinical trials are research studies conducted to explore and evaluate new treatments, therapies, and diagnostic tools for ALS, commonly known as Lou Gehrig’s disease. These trials are crucial in the search for effective ways to slow the progression of the disease, manage symptoms, and ultimately find a cure for ALS.

The importance of clinical trials in ALS research

Clinical trials are essential in ALS research as they are the primary method for testing new treatments and interventions. They help in understanding the effectiveness and safety of these treatments in humans. Through these trials, researchers can uncover new insights into the disease, leading to improved care, symptom management, and potentially life-extending therapies for those affected by ALS.

Types of ALS clinical trials

Innovations in ALS treatment through clinical trials

Who can participate in ALS clinical trials?

How to enroll in an ALS clinical trial