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Head & Neck Cancer Clinical Trials

Browse 313 head & neck cancer clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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A Study of VET3-TGI in Patients With Solid Tumors

for
Solid Tumor, Adult, Microsatellite Stable Colorectal Cancer,
Location: Miami FL, Pittsburgh PA, Indianapolis IN, Houston TX,
Sponsor: KaliVir Immunotherapeutics

Sex: All

Age: 18+

Code: NCT06444815

Phase1, Recruiting

Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy

for
Head and Neck Squamous Cell Carcinoma, Brain Metastases
Location: Nashville TN
Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All

Age: 18+

Code: NCT05996432

Early_phase1, Recruiting

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

for
Non Small Cell Lung Cancer, Esophageal Cancer,
Location: Boston MA, New Haven CT, New York NY,
Sponsor: SystImmune Inc.

Sex: All

Age: 18+

Code: NCT05983432

Phase1, Recruiting

Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma of the Head and Neck

for
Squamous Cell Carcinoma, Nonmelanoma Skin Cancer,
Location: Indianapolis IN
Sponsor: Indiana University

Sex: All

Age: 18+

Code: NCT05108090

Recruiting

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

for
Diffuse Astrocytoma, IDH-Mutant, Glioblastoma, IDH-wildtype,
Location: Boston MA, Boynton Beach FL, Nashville TN, Dallas TX,
Sponsor: Neonc Technologies, Inc.

Sex: All

Age: 18+

Code: NCT06047379

Phase1, Phase2, Recruiting

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Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck

for
Recurrent Adenoid Cystic Carcinoma of the Oral Cavity,
Location: Columbus OH
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT01473784

Recruiting

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

for
Non Small Cell Lung Cancer, Triple Negative Breast Cancer,
Location: Boston MA, Buffalo NY, Orlando FL, Sarasota FL,
Sponsor: Compass Therapeutics

Sex: All

Age: 18+

Code: NCT06150664

Phase1, Recruiting

Biospecimen Procurement for Head and Neck Disorders

for
Hearing Disorder, Oral Mucosal Disease, Pharyngeal Neoplasm,
Location: Baltimore MD, Washington D.C. DC, Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 3 - 70+

Code: NCT03429036

Recruiting

Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

for
Cancer, Solid Tumor, Melanoma, Renal Cell Carcinoma,
Location: Boston MA, New Haven CT, Buffalo NY, Tampa FL,
Sponsor: Simcha IL-18, Inc.

Sex: All

Age: 18+

Code: NCT04787042

Phase1, Phase2, Recruiting

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for
Non-small Cell Lung Cancer,
Location: Boston MA, New York NY, New Brunswick NJ, Pittsburgh PA,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT05877599

Phase1, Recruiting

Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

for
Metastatic Malignant Solid Neoplasm, Metastatic Melanoma,
Location: Duarte CA, Los Angeles CA, Stanford CA
Sponsor: Anusha Kalbasi

Sex: All

Age: 18 - 70+

Code: NCT04119024

Phase1, Recruiting

Phase II Trial of Neoadjuvant and Adjuvant IO102-IO103 and Pembrolizumab KEYTRUDA® in Patients With Resectable Tumors

for
Melanoma, Squamous Cell Carcinoma of Head and Neck
Location: Boston MA, New Haven CT, Richmond VA
Sponsor: IO Biotech

Sex: All

Age: 18+

Code: NCT05280314

Phase2, Recruiting

A Study of Evofosfamide in Combination with Zalifrelimab and Balstilimab

for
Metastatic Prostate Cancer,
Location: Houston TX
Sponsor: ImmunoGenesis

Sex: All

Age: 18+

Code: NCT06782555

Phase1, Phase2, Recruiting

Study to Evaluate LB-LR1109, Administered Alone for the Treatment of Solid Tumor and in Combination With Atezolizumab for the Treatment of NSCLC

for
Non-small Cell Lung Cancer(NSCLC),
Location: Fairfax VA
Sponsor: LG Chem

Sex: All

Age: 18+

Code: NCT06332755

Phase1, Recruiting

Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation

for
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT06662058

Recruiting

A Study of NX-1607 in Adults With Advanced Malignancies

for
Ovarian Cancer, Epithelial, Gastric Cancer,
Location: Charlottesville VA, Chapel Hill NC, Chicago IL,
Sponsor: Nurix Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05107674

Phase1, Recruiting

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

for
Advanced Solid Tumor, Unresectable Solid Tumor,
Location: New York NY, Hackensack NJ, Philadelphia PA,
Sponsor: Clasp Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06778863

Phase1, Recruiting

Oropharynx (OPX) Biomarker Trial

for
Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06356272

Recruiting

A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agents

for
Cancer, Tumor, Solid, Malignant Neoplasm, Metastatic Cancer,
Location: Austin TX, San Antonio TX, Scottsdale AZ
Sponsor: OncoResponse, Inc.

Sex: All

Age: 18+

Code: NCT05094804

Phase1, Phase2, Recruiting

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

for
Anatomic Stage III Breast Cancer AJCC v8,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 16+

Code: NCT05269381

Phase1, Phase2, Recruiting