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Head & Neck Cancer Clinical Trials

Browse 313 head & neck cancer clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors

for
Non Small Cell Lung Cancer,
Location: Boston MA, Austin, TX 78758 TX, San Antonio TX
Sponsor: Zumutor Biologics Inc.

Sex: All

Age: 18+

Code: NCT06451497

Phase1, Recruiting

Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

for
Bladder Cancer, Head and Neck Squamous Cell Carcinoma,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 18+

Code: NCT03740256

Phase1, Recruiting

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

for
Advanced Solid Tumor, High Grade Serous Adenocarcinoma of Ovary,
Location: Providence RI, New Haven CT, New York NY, Baltimore MD,
Sponsor: Volastra Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05902988

Phase1, Phase2, Recruiting

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

for
Advanced Esophageal Squamous Cell Carcinoma,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06265285

Phase2, Recruiting

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

for
Carcinoma, Non-Small Cell Lung,
Location: Boston MA, Newton MA, Shirley NY, Riverhead NY,
Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All

Age: 18+

Code: NCT04389632

Phase1, Recruiting

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Immunotherapy Study of Evofosfamide in Combination With Ipilimumab

for
Pancreatic Cancer, Melanoma,
Location: Houston TX
Sponsor: Threshold Pharmaceuticals

Sex: All

Age: 18+

Code: NCT03098160

Phase1, Recruiting

HPV DNA-Guided Radiotherapy De-intensification of Head and Neck Squamous Cell Carcinoma

for
Squamous Cell Carcinoma of the Oropharynx
Location: Richmond VA, Charlottesville VA, Miami FL
Sponsor: University of Virginia

Sex: All

Age: 18+

Code: NCT05962242

Phase2, Recruiting

An Investigational Scan (hpMRI) for Monitoring Treatment Response in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck Undergoing Radiation Therapy and/or Systemic Therapy

for
Thyroid Gland Carcinoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04589624

Phase1, Recruiting

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

for
Melanoma, NSCLC, Hepatocellular Carcinoma, Urothelial Cancer,
Location: Pittsburgh PA
Sponsor: Dan Zandberg

Sex: All

Age: 18+

Code: NCT04114136

Phase2, Recruiting

High-Resolution PET-CT Imaging for Surgical Margin Visualization

for
Cancer, Solid Malignant Tumors, SCC - Squamous Cell Carcinoma,
Location: Nashville TN
Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All

Age: 18+

Code: NCT06915454

Recruiting
Featured

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

for
Non-Small Cell Lung Cancer,
Location: Montreal, Fairfax VA, Durham NC, Toronto,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT05005403

Phase1, Recruiting

Reflectance Confocal Microscopy of Oral Cancers in Vivo: a Preliminary Trial Comparing Intra-oral Imaging With Pathology

for
Head and Neck Cancer,
Location: Uniondale NY, Harrison NY, New York NY, Middletown NJ,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT02507141

Recruiting

PromotinG Lung Cancer screenIng Awareness and Implementation in Hispanics/Latinx Head and Neck canceR Survivors

for
Head and Neck Cancer
Location: Miami FL
Sponsor: University of Miami

Sex: All

Age: 18 - 70+

Code: NCT06124508

Recruiting

Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC

for
Head and Neck Cancer, Relapse, Recurrent, Refractory Cancer
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT06096038

Phase1, Recruiting

A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)

for
Head and Neck Cancer, Unknown Primary Cancer,
Location: Dallas TX
Sponsor: University of Texas Southwestern Medical Center

Sex: All

Age: 18 - 70+

Code: NCT05576974

Phase2, Recruiting

Invert-Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy

for
Head and Neck Cancer
Location: Dallas TX
Sponsor: University of Texas Southwestern Medical Center

Sex: All

Age: 18 - 70+

Code: NCT06477692

Phase2, Recruiting

A Study of Neurocognitive Tests and Questionnaires for People With Head and Neck Cancer Who Are Undergoing Radiation Therapy

for
Head and Neck Cancer
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18 - 70+

Code: NCT05207098

Recruiting

Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia

for
Head and Neck Cancer
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT07278557

Phase2, Recruiting

Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC

for
Squamous Cell Carcinoma, Head and Neck Cancer
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT06137274

Phase2, Recruiting
New

Effects of Infusion Timing on Treatment Response in Solid Tumors

for
Lung Cancer, Non-small Cell Lung Cancer, Metastatic Lung Cancer,
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT07630168

Phase2, Recruiting