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Opioid Use Disorder Clinical Trials

Browse 196 Opioid Use Disorder clinical trials enrolling across the United States and Canada. 87 people applied to Opioid Use Disorder studies last month. Search by city or state to find one near you.

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Virtual Reality Analgesia In Trauma Rehab

for
Virtual Reality, Musculoskeletal Pain, Opioid Use, Anxiety,
Location: Bronx NY
Sponsor: New York City Health and Hospitals Corporation

Sex: All

Age: 18 - 70+

Code: NCT03894592

Recruiting

Optimizing Pregnancy and Treatment Interventions for Moms 3.0

for
Opioid Abuse (Disorder), Stimulant Use Disorders
Location: Salt Lake City UT
Sponsor: University of Utah

Sex: Female

Age: 18+

Code: NCT07586917

Recruiting

Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

for
Orthopedic Trauma Surgery Patients, Postoperative Pain,
Location: Lubbock TX
Sponsor: Texas Tech University Health Sciences Center

Sex: All

Age: 18 - 65

Code: NCT06903819

Recruiting

Real-time Opioid Study

for
Substance Use Disorder (SUD)
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 18 - 50

Code: NCT07768007

Recruiting

Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation

for
HIV Infections, Substance Use Disorders, Addiction, Opioid Use,
Location: Frederick MD
Sponsor: Johns Hopkins University

Sex: All

Age: 18+

Code: NCT06103370

Recruiting

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Leveraging mHealth to Promote Opioid Use Recovery and Mental Health Among Residents of a Medium-Sized Midwestern City

for
Opioid Use, Stimulant Use, Depression and Anxiety Symptoms
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT07673380

Phase2, Recruiting

Vanderbilt Integrated Community TMS for Opioid Recovery

for
Opiod Use Disorder
Location: Nashville TN, Brentwood TN
Sponsor: Vanderbilt University Medical Center

Sex: All

Age: 18 - 65

Code: NCT07457489

Recruiting

Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures

for
Opioid Use, Fractures, Bone, Trauma
Location: Detroit MI
Sponsor: Henry Ford Health System

Sex: All

Age: 18 - 70+

Code: NCT06113211

Recruiting

fMRI and Opioid Abstinence

for
Drug Use Disorder, Opioid Dependence, Opioid-Related Disorders,
Location: Hartford CT, New Haven CT
Sponsor: Yale University

Sex: All

Age: 18 - 50

Code: NCT06651333

Recruiting

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

for
Mood Disorders, Anxiety, Depressive Symptoms, Depression,
Location: Monroeville PA, Pittsburgh PA
Sponsor: University of Pittsburgh

Sex: All

Age: 18 - 70+

Code: NCT05658796

Recruiting

Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery

for
Postoperative Pain, Anxiety Postoperative, Opioid Use
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18+

Code: NCT04912531

Recruiting

Testing Implementation Strategies to Scale-up a Multicomponent Continuum of Service Intervention for Families Involved in Systems With Parental Opioid and Methamphetamine Use

for
Substance Related Disorders
Location: Eugene OR
Sponsor: Chestnut Health Systems

Sex: All

Age: 0+

Code: NCT07365293

Recruiting

Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention

for
Polysubstance Addiction, Opioid Medication Assisted Treatment,
Location: Denton MD
Sponsor: University of Maryland, College Park

Sex: All

Age: 18+

Code: NCT05973838

Recruiting

Evaluation of the Interactions of Cannabidiol (CBD) With Morphine

for
Opioid Use Disorder
Location: Overland Park KS
Sponsor: National Institute on Drug Abuse (NIDA)

Sex: All

Age: 18 - 55

Code: NCT05143424

Phase1, Recruiting

Assessing Optimal XRB Initiation Points in Jail

for
Opioid Use Disorder
Location: Boston MA, Springfield MA, New York NY,
Sponsor: NYU Langone Health

Sex: Male

Age: 0+

Code: NCT06051890

Recruiting

Transcutaneous Auricular Neurostimulation After Lumbar Surgery

for
Pain, Postoperative, Opioid Use, Lumbar Spine Injury
Location: Dallas TX
Sponsor: University of Texas Southwestern Medical Center

Sex: All

Age: 18 - 70+

Code: NCT06100172

Recruiting

What are Opioid Use Disorder clinical trials?

Opioid use disorder is now understood much like other chronic health conditions: ongoing management and support tend to work far better than a single fixed intervention, similar to how diabetes or high blood pressure are managed over time rather than resolved once. Opioid Use Disorder clinical trials are research studies that explore different approaches to supporting recovery, reducing overdose risk, and helping people manage cravings and withdrawal. Researchers use these studies to better understand what actually helps people build long-term recovery, and how different types of support, including counseling and medications for opioid use disorder, affect outcomes over time.

The importance of clinical trials in Opioid Use Disorder research

Opioid clinical trials are an important part of how opioid use disorder is understood and addressed at a national level. They help researchers learn more about recovery patterns, identify what kind of support works best for different people, and offer structured, closely monitored pathways for those seeking help. This kind of research also helps shape recovery programs and public health efforts nationwide.

Types of Opioid Use Disorder clinical trials

Who can participate in Opioid Use Disorder clinical trials?

Does information stay confidential when participating in an Opioid Use Disorder clinical trial?

How to enroll in a clinical trial for Opioid Use Disorder