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Opioid Use Disorder Clinical Trials

Browse 196 Opioid Use Disorder clinical trials enrolling across the United States and Canada. 87 people applied to Opioid Use Disorder studies last month. Search by city or state to find one near you.

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Active & Responsive

Methadone Patient Access to Collaborative Treatment

for
Opioid Use Disorder, Staff, Patients
Location: Tucson AZ
Sponsor: University of Arizona

Sex: All

Age: 18+

Code: NCT06556602

Recruiting
Active & Responsive

Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment

for
Alcohol Use Disorder, Opioid Use Disorder, Alcohol Use,
Location: Notre Dame IN
Sponsor: University of Notre Dame

Sex: All

Age: 18+

Code: NCT07342504

Recruiting
Active & Responsive

Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses

for
Opioid Use Disorder, Opioid Use Disorder, Severe,
Location: Washington D.C. DC, Greenville SC, Milwaukee WI,
Sponsor: Montefiore Medical Center

Sex: All

Age: 18+

Code: NCT07631598

Recruiting
Active & Responsive

MDMA for Co-occurring PTSD and OUD After Childbirth

for
Stress Disorders, Post-Traumatic, Opioid Use Disorder
Location: Albuquerque NM
Sponsor: University of New Mexico

Sex: Female

Age: 18+

Code: NCT05219175

Phase2, Recruiting
Active & Responsive

Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder

for
Substance Use Disorder (SUD), Opioid Use Disorder (OUD)
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 22 - 70+

Code: NCT07214467

Recruiting

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Active & Responsive

TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)

for
Alcohol Use Disorder, Opioid Use Disorder
Location: Portland OR
Sponsor: Washington State University

Sex: All

Age: 18+

Code: NCT07171359

Recruiting
Active & Responsive

Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

for
Opioid Use Disorder
Location: Boston MA, Huntington WV, Minneapolis MN, Denver CO,
Sponsor: Yale University

Sex: All

Age: 18 - 70+

Code: NCT06323824

Recruiting
Active & Responsive

Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

for
Opioid Use Disorder
Location: Baltimore MD
Sponsor: Johns Hopkins University

Sex: All

Age: 21 - 70

Code: NCT06067737

Phase2, Recruiting
Active & Responsive

A Study of Brenipatide in Participants With Opioid Use Disorder

for
Opioid Use Disorder
Location: Boston MA, Watertown MA, Providence RI, The Bronx NY,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18 - 70+

Code: NCT07420283

Phase2, Recruiting
Active & Responsive

Optimization of NIBS for Treatment of Addiction

for
Opioid-use Disorder, Chronic Pain
Location: Cambridge MA, Cleveland OH, Hinsdale IL
Sponsor: Case Western Reserve University

Sex: All

Age: 18 - 70+

Code: NCT04379115

Recruiting
Active & Responsive

Study to Assess the Use of Tezampanel for Opioid Withdrawal Syndrome in Treatment-Seeking Patients With Opioid Use Disorder

for
Opioid Use Disorder
Location: Indianapolis IN
Sponsor: Proniras Corporation

Sex: All

Age: 18 - 65

Code: NCT06538558

Phase1, Recruiting
Active & Responsive

A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

for
Opioid Use Disorder
Location: West Haven CT, Philadelphia PA, Wilmington DE,
Sponsor: VA Office of Research and Development

Sex: All

Age: 18+

Code: NCT04375033

Recruiting
Active & Responsive

Standard Versus High Dose ED-Initiated Buprenorphine Induction

for
Opioid Use Disorder
Location: Portland ME, Camden NJ, Salt Lake City UT,
Sponsor: Yale University

Sex: All

Age: 18 - 65

Code: NCT06494904

Phase3, Recruiting
Active & Responsive

Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder

for
Opioid Use Disorder, Opioid Use Disorder, Moderate,
Location: Morgantown WV, Jacksonville FL, Tampa FL, Greenville SC,
Sponsor: T. John Winhusen, PhD

Sex: All

Age: 18+

Code: NCT06651177

Phase2, Recruiting
Active & ResponsiveNew

Pilot Testing of the emPath Platform to Improve Medication for Opioid Use Disorder (MOUD) Linkage and Retention Among Adults With Opioid Use Disorder in Durham, North Carolina

for
Opioid Use Disorder, Digital Health Intervention, Telemedicine,
Location: Durham NC
Sponsor: Duke University

Sex: All

Age: 18+

Code: NCT07810322

Recruiting
Active & Responsive

Cannabis and Opioid Use Disorder

for
Opioid Use Disorder
Location: Lexington KY
Sponsor: Shanna Babalonis, PhD

Sex: All

Age: 18 - 55

Code: NCT05729932

Phase1, Recruiting
Active & Responsive

An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)

for
Opioid Use Disorder, Neonatal Abstinence Syndrome
Location: Philadelphia PA
Sponsor: University of Pennsylvania

Sex: All

Age: 18+

Code: NCT06576323

Recruiting
Active & Responsive

tDCS to Decrease Opioid Relapse (UH3)

for
Opioid Use Disorder
Location: Providence RI
Sponsor: Butler Hospital

Sex: All

Age: 21 - 60

Code: NCT06432465

Recruiting
Active & Responsive

Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose

for
Opioid Use Disorder
Location: Providence RI
Sponsor: Rhode Island Hospital

Sex: All

Age: 18+

Code: NCT06316830

Phase2, Phase3, Recruiting
Active & Responsive

Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women

for
HIV, Opioid Use Disorder, eHealth
Location: New Haven CT, Birmingham AL
Sponsor: Yale University

Sex: Female

Age: 18+

Code: NCT05547048

Recruiting

What are Opioid Use Disorder clinical trials?

Opioid use disorder is now understood much like other chronic health conditions: ongoing management and support tend to work far better than a single fixed intervention, similar to how diabetes or high blood pressure are managed over time rather than resolved once. Opioid Use Disorder clinical trials are research studies that explore different approaches to supporting recovery, reducing overdose risk, and helping people manage cravings and withdrawal. Researchers use these studies to better understand what actually helps people build long-term recovery, and how different types of support, including counseling and medications for opioid use disorder, affect outcomes over time.

The importance of clinical trials in Opioid Use Disorder research

Opioid clinical trials are an important part of how opioid use disorder is understood and addressed at a national level. They help researchers learn more about recovery patterns, identify what kind of support works best for different people, and offer structured, closely monitored pathways for those seeking help. This kind of research also helps shape recovery programs and public health efforts nationwide.

Types of Opioid Use Disorder clinical trials

Who can participate in Opioid Use Disorder clinical trials?

Does information stay confidential when participating in an Opioid Use Disorder clinical trial?

How to enroll in a clinical trial for Opioid Use Disorder