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Opioid Use Disorder Clinical Trials

Browse 196 Opioid Use Disorder clinical trials enrolling across the United States and Canada. 87 people applied to Opioid Use Disorder studies last month. Search by city or state to find one near you.

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1

Adolescent Outcomes of Post-operative Opioid EXposure

for
Opioid Use Disorder, Pain, Chronic
Location: Boston MA
Sponsor: Sharon Levy

Sex: All

Age: 12 - 17

Code: NCT06350409

Recruiting

Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder

for
Opioid Use Disorder
Location: Colton CA
Sponsor: RAND

Sex: All

Age: 18+

Code: NCT06827288

Recruiting

OUD (Opioid Use Disorder) Target Trial

for
Opioid Use Disorder
Location: Durham NC
Sponsor: Duke University

Sex: All

Age: 18+

Code: NCT06585709

Recruiting

Low-Intensity Focused Ultrasound and the Complex Patient

for
Opioid Use Disorder, Chronic Pain, Anxiety Disorder
Location: Roanoke VA
Sponsor: Virginia Polytechnic Institute and State University

Sex: All

Age: 18 - 65

Code: NCT06297200

Recruiting

Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)

for
Opioid Use Disorder
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 25 - 55

Code: NCT06160284

Phase1, Recruiting

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Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

for
Pain, Postoperative, Ankle Fracture Surgery,
Location: St Louis MO
Sponsor: Jenna-Leigh Wilson

Sex: All

Age: 18+

Code: NCT06949826

Recruiting

Improving Office Based Treatment of Opioid Use Disorder With Technology

for
Opioid-use Disorder
Location: Baltimore MD
Sponsor: MedicaSafe, Inc.

Sex: All

Age: 18 - 65

Code: NCT03586466

Recruiting

Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

for
Opioid-Related Disorders, Drug Addiction
Location: Baltimore MD
Sponsor: National Institute on Drug Abuse (NIDA)

Sex: All

Age: 21 - 60

Code: NCT03745339

Recruiting

Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

for
Tobacco-flavored EC, Sweet-Cooling EC, Sweet Non-cooling EC
Location: Greenville SC
Sponsor: Prisma Health-Upstate

Sex: All

Age: 21+

Code: NCT07202039

Recruiting

Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications.

for
Substance Use Disorder (SUD)
Location: Milwaukee WI
Sponsor: Medical College of Wisconsin

Sex: Female

Age: 18 - 40

Code: NCT06617949

Early_phase1, Recruiting

Developing a Smartphone Application to Support Veteran Opioid Use Disorder Treatment

for
Opioid-Related Disorders, Psychosocial Functioning,
Location: West Haven CT
Sponsor: VA Office of Research and Development

Sex: All

Age: 18+

Code: NCT06454903

Recruiting

Acetazolamide in Central Sleep Apnea Patients Using Medication for Opioid Use Disorder

for
Central Sleep Apnea Comorbid With Opioid Use
Location: Pittsburgh PA
Sponsor: Sanjay R Patel

Sex: All

Age: 18 - 70+

Code: NCT06521476

Phase2, Recruiting

Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder

for
Alcohol Use Disorder
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 21 - 70

Code: NCT05957159

Early_phase1, Recruiting

Sleep Disordered Breathing With Opioid Use

for
Sleep Apnea, Opioid Use, Sleep Disordered Breathing
Location: Detroit MI
Sponsor: VA Office of Research and Development

Sex: All

Age: 18 - 70+

Code: NCT05589753

Phase1, Phase2, Recruiting
New

Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use

for
Opioid Use, Substance Use Disorders, Opioid Analgesia
Location: Houston TX
Sponsor: Christopher D. Verrico

Sex: All

Age: 18 - 55

Code: NCT07218549

Phase1, Recruiting

The Staying Safe Intervention

for
Hepatitis C, Opioid Use
Location: New York NY
Sponsor: National Development and Research Institutes, Inc.

Sex: All

Age: 18 - 29

Code: NCT03418636

Recruiting

Pre-operative Education Modalities to Decrease Opioid Use

for
Prostatectomy, Opioid-Related Disorders
Location: Seattle WA
Sponsor: Benaroya Research Institute

Sex: Male

Age: 18+

Code: NCT04933084

Recruiting

Preventing OUD in Justice-Involved Youth

for
Substance Use Disorders, Recidivism
Location: Olympia WA
Sponsor: Seattle Children's Hospital

Sex: All

Age: 15 - 25

Code: NCT04901312

Recruiting

Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain

for
Chronic Pain, Chronic Insomnia, Opioid Use
Location: Tampa FL
Sponsor: University of South Florida

Sex: All

Age: 18+

Code: NCT06345872

Recruiting

Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients

for
Orthopaedic Trauma, Chronic Opioid Use
Location: Boston MA, Nashville TN
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18 - 70

Code: NCT06201676

Recruiting

What are Opioid Use Disorder clinical trials?

Opioid use disorder is now understood much like other chronic health conditions: ongoing management and support tend to work far better than a single fixed intervention, similar to how diabetes or high blood pressure are managed over time rather than resolved once. Opioid Use Disorder clinical trials are research studies that explore different approaches to supporting recovery, reducing overdose risk, and helping people manage cravings and withdrawal. Researchers use these studies to better understand what actually helps people build long-term recovery, and how different types of support, including counseling and medications for opioid use disorder, affect outcomes over time.

The importance of clinical trials in Opioid Use Disorder research

Opioid clinical trials are an important part of how opioid use disorder is understood and addressed at a national level. They help researchers learn more about recovery patterns, identify what kind of support works best for different people, and offer structured, closely monitored pathways for those seeking help. This kind of research also helps shape recovery programs and public health efforts nationwide.

Types of Opioid Use Disorder clinical trials

Who can participate in Opioid Use Disorder clinical trials?

Does information stay confidential when participating in an Opioid Use Disorder clinical trial?

How to enroll in a clinical trial for Opioid Use Disorder