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Opioid Use Disorder Clinical Trials

Browse 196 Opioid Use Disorder clinical trials enrolling across the United States and Canada. 87 people applied to Opioid Use Disorder studies last month. Search by city or state to find one near you.

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Symptom-Inhibited Naloxone Induction (SINI) for Buprenorphine Initiation: A Feasibility Trial

for
Opioid Use Disorder
Location: Vancouver
Sponsor: Pouya Azar

Sex: All

Age: 19+

Code: NCT07439549

Recruiting

Evaluating Buspirone to Treat Opioid Withdrawal

for
Opioid Use Disorder, Opioid Withdrawal, Opioid Craving, Anxiety
Location: Baltimore MD
Sponsor: University of Maryland, Baltimore

Sex: All

Age: 18 - 70+

Code: NCT05511909

Phase2, Recruiting

Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD

for
Opioid Use Disorder, Poor Quality Sleep
Location: Charleston SC
Sponsor: Medical University of South Carolina

Sex: All

Age: 18+

Code: NCT06157840

Recruiting

PRoducing Outcome Measures for OTP Quality Improvement

for
Opioid Use Disorder
Location: Research Triangle Park NC
Sponsor: RTI International

Sex: All

Age: 18+

Code: NCT07214389

Recruiting

Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

for
Opioid Use Disorder
Location: Greenville SC
Sponsor: Prisma Health-Upstate

Sex: All

Age: 18+

Code: NCT07541417

Recruiting

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A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid Use

for
Opioid Use Disorder
Location: New York NY
Sponsor: Rachel R. Luba

Sex: All

Age: 18 - 65

Code: NCT06726200

Early_phase1, Recruiting

Autobiographical Memory in Opioid Use Disorder

for
Opioid Use Disorder
Location: Philadelphia PA
Sponsor: University of Pennsylvania

Sex: All

Age: 18 - 60

Code: NCT06643988

Recruiting

Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder

for
Opioid Withdrawal, Opioid Use Disorder
Location: Center City MN
Sponsor: Spark Biomedical, Inc.

Sex: All

Age: 18 - 50

Code: NCT06487533

Recruiting

Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform

for
Opioid Use Disorder
Location: New York NY
Sponsor: Friends Research Institute, Inc.

Sex: All

Age: 18 - 70+

Code: NCT06573476

Recruiting

Combined Guanfacine and Mindfulness Meditation as an Adjunct to Buprenorphine Maintenance in Opioid Use Disorder

for
Mindfulness, Guanfacine, Opioid Use Disorder
Location: Newark NJ
Sponsor: Rutgers, The State University of New Jersey

Sex: All

Age: 18 - 55

Code: NCT06642181

Phase1, Recruiting

AvertD Post-Approval Study

for
Opioid Use Disorder
Location: Indianapolis IN
Sponsor: Prescient Medicine Holdings, Inc.

Sex: All

Age: 18+

Code: NCT07135323

Recruiting

Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects

for
Opioid Use Disorder, Opioid Use, Insomnia, Orexin Antagonist
Location: Richmond VA
Sponsor: Virginia Commonwealth University

Sex: All

Age: 18+

Code: NCT06981195

Phase2, Recruiting

Semaglutide for Helping Opioid Recovery

for
Opioid Use Disorder
Location: Boston MA
Sponsor: Brigham and Women's Hospital

Sex: All

Age: 18+

Code: NCT06639464

Phase2, Recruiting

Telehealth vs In-Person Evaluation of Addiction Treatment After Visiting the Emergency Department

for
Opioid Use Disorder
Location: El Centro CA, Sylmar CA, Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT06961058

Recruiting

Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder

for
Opioid Use Disorder
Location: Minneapolis MN
Sponsor: University of Minnesota

Sex: All

Age: 18+

Code: NCT07158853

Phase1, Recruiting

Deep Brain Stimulation Effects In Patients With Opioid Use Disorder

for
Opioid-use Disorder
Location: Pittsburgh PA
Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Sex: All

Age: 22 - 65

Code: NCT04354077

Recruiting

Ketamine Assisted Psychotherapy for Opioid Use Disorder

for
Opioid-use Disorder
Location: Salt Lake City UT
Sponsor: University of Utah

Sex: All

Age: 18+

Code: NCT04892251

Phase1, Phase2, Recruiting

Smartphones for Opiate Addiction Recovery

for
Opioid-use Disorder
Location: New York NY
Sponsor: NYU Langone Health

Sex: All

Age: 18 - 70+

Code: NCT05033028

Phase3, Recruiting

Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD

for
Opioid Use Disorder, Posttraumatic Stress Disorder
Location: Burlington VT
Sponsor: University of Vermont

Sex: All

Age: 18+

Code: NCT06288711

Recruiting

A Bundled Intervention

for
Opioid Use Disorder, Opioid Overdose
Location: Birmingham AL
Sponsor: University of Alabama at Birmingham

Sex: All

Age: 19+

Code: NCT06593093

Phase1, Phase2, Recruiting

What are Opioid Use Disorder clinical trials?

Opioid use disorder is now understood much like other chronic health conditions: ongoing management and support tend to work far better than a single fixed intervention, similar to how diabetes or high blood pressure are managed over time rather than resolved once. Opioid Use Disorder clinical trials are research studies that explore different approaches to supporting recovery, reducing overdose risk, and helping people manage cravings and withdrawal. Researchers use these studies to better understand what actually helps people build long-term recovery, and how different types of support, including counseling and medications for opioid use disorder, affect outcomes over time.

The importance of clinical trials in Opioid Use Disorder research

Opioid clinical trials are an important part of how opioid use disorder is understood and addressed at a national level. They help researchers learn more about recovery patterns, identify what kind of support works best for different people, and offer structured, closely monitored pathways for those seeking help. This kind of research also helps shape recovery programs and public health efforts nationwide.

Types of Opioid Use Disorder clinical trials

Who can participate in Opioid Use Disorder clinical trials?

Does information stay confidential when participating in an Opioid Use Disorder clinical trial?

How to enroll in a clinical trial for Opioid Use Disorder