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Opioid Use Disorder Clinical Trials

Browse 196 Opioid Use Disorder clinical trials enrolling across the United States and Canada. 87 people applied to Opioid Use Disorder studies last month. Search by city or state to find one near you.

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1

Machine-Learning Prediction and Reducing Overdoses With EHR Nudges

for
Opioid Overdose, Opioid Use, Opioid Use Disorder, Opioids
Location: Pittsburgh PA
Sponsor: University of Pittsburgh

Sex: All

Age: 18+

Code: NCT06806163

Recruiting

Comparing Rapid Micro-Induction and Standard Induction of Buprenorphine/Naloxone for Treatment of Opioid Use Disorder

for
Opioid Use Disorder
Location: Vancouver
Sponsor: University of British Columbia

Sex: All

Age: 19+

Code: NCT04234191

Phase2, Recruiting

Longitudinal Neural Fingerprinting of Opioid-use Trajectories

for
Opioid Use Disorder
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 18 - 50

Code: NCT06207162

Recruiting

Cannabidiol in Opioid Use Disorder and Chronic Pain

for
Chronic Pain, Opioid Use Disorder
Location: West Haven CT
Sponsor: Yale University

Sex: All

Age: 18 - 70

Code: NCT04587791

Early_phase1, Recruiting

Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency Departments

for
Opioid-use Disorder
Location: Edmonton, Calgary, Vancouver
Sponsor: University of British Columbia

Sex: All

Age: 18+

Code: NCT04893525

Phase2, Phase3, Recruiting

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Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD Adherence to Adolescents With OUD

for
Opioid Use Disorder
Location: Baltimore MD
Sponsor: Potomac Health Foundations

Sex: All

Age: 13 - 21

Code: NCT06774248

Recruiting

Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes

for
Opioid-use Disorder, Opioid Misuse, Opioid Use, Chronic Pain
Location: Mobile AL
Sponsor: Sure Med Compliance

Sex: All

Age: 18+

Code: NCT04945525

Recruiting

Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder

for
Opioid-use Disorder
Location: Rockville MD
Sponsor: New York State Psychiatric Institute

Sex: All

Age: 18 - 65

Code: NCT05011266

Phase2, Phase3, Recruiting

Pilot Testing a Novel Remotely Delivered Intensive Outpatient Program for Individuals With OUD

for
Opioid Use Disorder, Serious Bacterial Infections
Location: Boston MA
Sponsor: Brigham and Women's Hospital

Sex: All

Age: 18+

Code: NCT05817825

Recruiting

Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD

for
Opioid Use Disorder
Location: Columbus OH
Sponsor: Ohio State University

Sex: All

Age: 18+

Code: NCT06718491

Recruiting

Combined THC and CBD for OUD and Chronic Pain

for
Chronic Pain, Opioid Use Disorder
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 18 - 65

Code: NCT06544291

Phase2, Recruiting

Aim 2 - Conversations Can Save Lives: TALKing About Buprenorphine & Methadone for Opioid Use Treatment Initiation

for
Opioid Use Disorder
Location: Springfield MA
Sponsor: Baystate Medical Center

Sex: All

Age: 18+

Code: NCT06527820

Recruiting

Reducing Opioid Mortality in Illinois

for
Opioid Use, Opioid-use Disorder
Location: Ottawa IL
Sponsor: University of Chicago

Sex: All

Age: 18+

Code: NCT04925427

Recruiting

Pain and Opioid Management in Older Adults

for
Pain, Chronic, Opioid Use Disorder
Location: Oklahoma City OK
Sponsor: University of Oklahoma

Sex: All

Age: 18+

Code: NCT05037682

Recruiting

Remotely Observed Methadone Evaluation II

for
Opioid Use Disorder
Location: Chicago IL
Sponsor: Sonara Health

Sex: All

Age: 18 - 64

Code: NCT06338280

Phase2, Recruiting

Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment

for
Opioid Use Disorder, Sleep Disturbance
Location: Birmingham AL
Sponsor: University of Alabama at Birmingham

Sex: All

Age: 18 - 70+

Code: NCT06104280

Recruiting

Rural New England Health Study (Phase 2)

for
Hepatitis C, Opioid Use Disorder, IV Drug Usage
Location: Keene NH, Brattleboro VT, Bennington VT
Sponsor: Baystate Medical Center

Sex: All

Age: 18+

Code: NCT05466331

Recruiting

Ketones for Opioid Craving

for
Opioid Use Disorder
Location: Wernersville PA
Sponsor: University of Maryland, Baltimore

Sex: All

Age: 18 - 70+

Code: NCT07128524

Phase2, Recruiting

EMS-Initiated Buprenorphine

for
Opioid Use Disorder
Location: Camden NJ, Minneapolis MN, Oakland CA
Sponsor: Yale University

Sex: All

Age: 0+

Code: NCT07475728

Recruiting

Psilocybin for Opioid Use Disorder (OUD)

for
Opioid Use Disorder
Location: The Bronx NY, Brooklyn NY, New York NY, Albuquerque NM
Sponsor: NYU Langone Health

Sex: All

Age: 18 - 65

Code: NCT06796062

Phase2, Recruiting

What are Opioid Use Disorder clinical trials?

Opioid use disorder is now understood much like other chronic health conditions: ongoing management and support tend to work far better than a single fixed intervention, similar to how diabetes or high blood pressure are managed over time rather than resolved once. Opioid Use Disorder clinical trials are research studies that explore different approaches to supporting recovery, reducing overdose risk, and helping people manage cravings and withdrawal. Researchers use these studies to better understand what actually helps people build long-term recovery, and how different types of support, including counseling and medications for opioid use disorder, affect outcomes over time.

The importance of clinical trials in Opioid Use Disorder research

Opioid clinical trials are an important part of how opioid use disorder is understood and addressed at a national level. They help researchers learn more about recovery patterns, identify what kind of support works best for different people, and offer structured, closely monitored pathways for those seeking help. This kind of research also helps shape recovery programs and public health efforts nationwide.

Types of Opioid Use Disorder clinical trials

Who can participate in Opioid Use Disorder clinical trials?

Does information stay confidential when participating in an Opioid Use Disorder clinical trial?

How to enroll in a clinical trial for Opioid Use Disorder